- The mechanism of phospholipase C-gamma1 regulation
-
Kim MJ, Kim EK, Ryu SH, Suh PG
- KMID: 755072
- Exp Mol Med.
- 2000 Sep;32(3):101-109.
Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while... -
- CITED
-
- Close
- SHARE
-
- Close
- Plasma cell granuloma in cyclosporin-induced gingival overgrowth: four cases report with interleukin-6 and phospholipase C-gammar1 immunohistochemistry
-
Sung IY, Son JH, Ryu SH, Seo JH, Kim SS, Choi IP, Ryu SH, Suh PG, Byeon KJ
- KMID: 1515849
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2003 Mar;25(2):155-160.
No abstract available. -
- CITED
-
- Close
- SHARE
-
- Close
- Mass Production and Characterization of Anti-HBsAg Human Antibody B7 Fd
-
Choi IH, Kim IJ, Chung JH, Choi SJ, Im JB, Yi KS, Suh PG, Ryu SH
- KMID: 2146908
- J Korean Soc Microbiol.
- 1999 Jun;34(3):265-275.
We expressed anti-HBsAg human antibody fragment (B7 Fd) using pRSET-A vector and BL21(DE3)pLysS strain of E. coli. B7 Fd is composed only of variable domain (VH) and CH1 constant domain... -
- CITED
-
- Close
- SHARE
-
- Close
- Expression of Phospholipase C-gamma1 and gamma2 in Non-Hodgkin's and Hodgkin's Lymphoma
-
Eom DW, Kim SS, Woo YJ, Suh JH, Huh J, Paik AR, Kim JH, Ryu SH, Suh PG
- KMID: 1725651
- Korean J Pathol.
- 2000 Feb;34(2):113-118.
Phospholipase C (PLC) plays a role in ligand-mediated signal transduction for cellular activity such as proliferation and differentiation. A recent observation that PLC- gamma1 is highly expressed in some kinds of... -
- CITED
-
- Close
- SHARE
-
- Close
- Cloning and characterization of 5'-upstream region of human phospholipase C-beta2 gene
-
Yun ES, Lee SJ, Kim MJ, Ryu SH, Suh PG
- KMID: 1085743
- Exp Mol Med.
- 2001 Jun;33(2):76-82.
5'-upstream region of the phospholipase C-beta2 gene, 810 bp, was cloned and characterized. S1 nuclease mapping and primer extension analyses revealed that a single transcriptional start site locates at 284... -
- CITED
-
- Close
- SHARE
-
- Close
- Immunohistochemical localization of eight phospholipase C isozymes in pancreatic islets of the mouse
-
Kim SS, Jun KS, Jeong MJ, Ryu SH, Suh PG, Shin HS
- KMID: 938881
- Exp Mol Med.
- 2001 Sep;33(3):164-168.
The possible involvement of phospholipase C (PLC) in the regulation of insulin secretion is not clearly understood and neither its isozymes expressed nor cellular localization in the pancreatic islets is... -
- CITED
-
- Close
- SHARE
-
- Close
- The mRNA Expression of Phosphoinositide-specific Phospholipase C-beta Isozymes in Postnatal Rat Brains
-
Rhyu IJ, Kim H, Kang YH, Park K, Hwang SJ, Suh PG, Suh YS
- KMID: 2092655
- Korean J Anat.
- 1998 Aug;31(4):535-544.
Phosphoinositide-specific phospholipase C(PLC) is known as a key enzyme which produces two major second messengers: diacylglycerol and inositol 1,4,5 trisphosphate. Although it has been suggested that PLC beta isozymes have... -
- CITED
-
- Close
- SHARE
-
- Close
- Phosphatidylinositol phosphates directly bind to neurofilament light chain (NF-L) for the regulation of NF-L self assembly
-
Kim SK, Kim H, Yang YR, Suh PG, Chang JS
- KMID: 1109404
- Exp Mol Med.
- 2011 Mar;43(3):153-160.
- doi: 10.3858/emm.2011.43.3.019
Phosphatidylinositol phosphates (PtdInsPs) are ubiquitous membrane phospholipids that play diverse roles in cell growth and differentiation. To clarify the regulation mechanism acting on neurofilament light chain (NF-L) self assembly, we... -
- CITED
-
- Close
- SHARE
-
- Close
- Enhanced expression of neuronal nitric oxide synthase and phospholipase C-gamma1 in regenerating murine neuronal cells by pulsed electromagnetic field
-
Kim SS, Shin HJ, Eom DW, Huh JR, Woo Y, Kim H, Ryu SH, Suh PG, Kim MJ, Kim JY, Koo TW, Cho YH, Chung SM
- KMID: 1093598
- Exp Mol Med.
- 2002 Mar;34(1):53-59.
Pulsed electromagnetic field (PEMF) has been shown to improve the rate of peripheral nerve regeneration. In the present study we investigated the expression of neuronal nitric oxide synthase (nNOS) and... -
- CITED
-
- Close
- SHARE
-
- Close
- Expression, Characterization and Chain Shuffling of an Anti-HBsAg Phage Antibody
-
Choi IH, Kim IJ, Choi SJ, Kim HJ, Chung JH, Yi KS, Lee SD, Suh PG
- KMID: 1551644
- J Korean Soc Microbiol.
- 1998 Jun;33(3):307-316.
In our previous report an anti-HBsAg human monoclonal antibody was generated using antibody phage display library technique. Using pComb3 filamentous phagemid vector, Fab molecule was expressed in fusion form to... -
- CITED
-
- Close
- SHARE
-
- Close
- Visuosocial Preference Memory, but Not Avoidance Memory, Requires PLCγ1 in the CA2 Hippocampus
-
Kim S, Kim J, Park YM, Suh PG, Lee CJ
- KMID: 2535064
- Exp Neurobiol.
- 2022 Oct;31(5):332-342.
- doi: 10.5607/en22033
Visuosocial memory is defined as stored visual information containing social context. Primates have a powerful ability to associate visuosocial memory with episodic memory. However, the existence of visuosocial memory in... -
- CITED
-
- Close
- SHARE
-
- Close
- Dexamethasone differentiates NG108-15 cells through cyclooxygenase1 induction
-
Kim HS, Song M, Kim E, Ryu SH, Suh PG
- KMID: 1094702
- Exp Mol Med.
- 2003 Jun;35(3):203-210.
Cyclooxygenase (COX) is a key enzyme in the conversion of arachidonic acid into prostanoids which participate in various cellular functions including apoptosis, mitogenesis, inflammation, immune modulation and differentiation. Moreover, the... -
- CITED
-
- Close
- SHARE
-
- Close
- Inositol 5'-phosphatase, SHIP1 interacts with phospholipase C-gamma1 and modulates EGF-induced PLC activity
-
Song M, Kim MJ, Ha S, Park JB, Ryu SH, Suh PG
- KMID: 1056227
- Exp Mol Med.
- 2005 Jun;37(3):161-168.
Phospholipase C-gamma1, containing two SH2 and one SH3 domains which participate in the interaction between signaling molecules, plays a significant role in the growth factor-induced signal transduction. However, the role... -
- CITED
-
- Close
- SHARE
-
- Close
- Plasma Cell Granuloma in Cyclosporine-Induced Gingival Overgrowth: A Report of Two Cases with Immunohistochemical Positivity of Interleukin-6 and Phospholipase C-gamma1
-
Kim SS, Eom DW, Huh JR, Sung IY, Choi IP, Ryu SH, Suh PG, Chung SM
- KMID: 1127268
- J Korean Med Sci.
- 2002 Oct;17(5):704-707.
- doi: 10.3346/jkms.2002.17.5.704
We report two cases of gingival plasma cell granuloma in a 34-yr-old and 40-yr-old two male renal transplant recipients with cyclosporine A (CsA)-induced gingival overgrowth (GO). Histologically, these lesions... -
- CITED
-
- Close
- SHARE
-
- Close
- The synthetic peptide, His-Phe-Tyr-Leu-Pro-Met, is a chemoattractant for Jukat T cells
-
Kim YD, Bae YS, Park JC, Suh PG, Ryu SH
- KMID: 1457539
- Exp Mol Med.
- 2001 Dec;33(4):257-262.
His-Phe-Tyr-Leu-Pro-Met (HFYLPM) is a synthetic peptide that stimulates Jurkat T cells resulting in intracellular calcium ([Ca2+]i) increase in a pertussis toxin (PTX)-sensitive manner. We have examined the physiological role of... -
- CITED
-
- Close
- SHARE
-
- Close
- Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway
-
Kim HS, Yumkham S, Kim SH, Yea K, Shin YC, Ryu SH, Suh PG
- KMID: 1105280
- Exp Mol Med.
- 2006 Feb;38(1):85-93.
The gastrointestinal functions of secretin have been fairly well established. However, its function and mode of action within the nervous system remain largely unclear. To gain insight into this area,... -
- CITED
-
- Close
- SHARE
-
- Close
- Alteration of Phospholipase C Activity in Human Gastric Cancer Tissues
-
Kim YO, Cho MY, Lee SD, Kim SS, Suh PG, Huh MH
- KMID: 1725066
- Korean J Pathol.
- 1996 Mar;30(3):210-217.
Phospholipase C (PLC) plays a pivotal role in transmembrane signal transduction pathway for cellular proliferation differentiation and growth. Thus far, there have been few reports in which PLC activity was... -
- CITED
-
- Close
- SHARE
-
- Close
- Sphingosine mediates FTY720-induced apoptosis in LLC-PK1 cells
-
Lee WJ, Yoo HS, Suh PG, Lim JS, Oh S, Lee YM
- KMID: 1123763
- Exp Mol Med.
- 2004 Oct;36(5):420-427.
FTY720, a synthetic sphingoid base analog, was examined as a new sphingosine kinase inhibitor, which converts endogenous sphingosine into its phosphate form. With 20 micrometer of FTY720, sphingosine accumulated in... -
- CITED
-
- Close
- SHARE
-
- Close
- A double point mutation in PCL-gamma1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation
-
Chung SH, Kim SK, Kim JK, Yang YR, Suh PG, Chang JS
- KMID: 946654
- Exp Mol Med.
- 2010 Mar;42(3):216-222.
- doi: 10.3858/emm.2010.42.3.023
Growth factor stimulation induces Y783 phosphorylation of phosphoinositide-specific PLC-gamma1, and the subsequent activation of this enzyme in a cellular signaling cascade. Previously, we showed that a double point mutation, Y509A/F510A,... -
- CITED
-
- Close
- SHARE
-
- Close
- The expression of phospholipase C and Siah gene product during murine fetal development by immunohistochemistry
-
Park EM, Kim SS, Choi KG, Park KD, Suh PG, Shin HS
- KMID: 2066076
- J Korean Neurol Assoc.
- 1997 Jun;15(3):455-462.
Recently identified second messenger molecules of signal transmission were derived from inositol phospholipid and several phospholipase C(PLC) isoenzyme were reconized. But the role of PLC in embryonal organ development, differentiation... -
- CITED
-
- Close
- SHARE
-
- Close
