Exp Mol Med.
2000 Sep;32(3):101-109.
The mechanism of phospholipase C-gamma1 regulation
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- 1Department of Life Science, Pohang University of Science and Technology, Kyungbuk, Korea.
Abstract
- Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-gamma1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-gamma1.
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