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Metabolic Alterations in Parkinson's Disease after Thalamotomy, as Revealed by 1H MR Spectroscopy

Baik HM, Choe BY, Lee HK, Suh TS, Son BC, Lee JM

OBJECTIVE: To determine, using proton magnetic resonance spectroscopy (1H MRS) whether thalamotomy in patients with Parkinson's disease gives rise to significant changes in regional brain metabolism. MATERIALS AND METHODS: Fifteen patients...
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Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers

Lee HJ, Baek SM, Ho DH, Suk JE, Cho ED, Lee SJ

Parkinson's disease (PD) is characterized by selective and progressive degeneration of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNpc) and by abnormal aggregation of alpha-synuclein. Previous studies have...
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