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No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma

Wang JZ, Le S, Alexanian , Boddu S, Merleev A, Marusina A, Maverakis

PURPOSE: To examine the association between phosphodiesterase type 5 (PDE5) inhibitor use and melanoma by 1) conducting a systematic review of observational studies; and 2) determining if low PDE5A gene...
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Pulmonary Arterial Hypertension and Pregnancy: Single Center Experience in Current Era of Targeted Therapy

Lim K, Chang SA, Oh SY, Lee JH, Song J, Kang IS, Huh J, Park SJ, Park SW, Kim DK

OBJECTIVES: To report our experiences in pregnant patients with pulmonary arterial hypertension (PAH) who were treated with targeted therapy. METHODS: From 2011 to 2017, women who decided to maintain pregnancies in...
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Obesity and Erectile Dysfunction: From Bench to Clinical Implication

Moon KH, Park SY, Kim YW

Obesity is a major public health issue worldwide and is frequently associated with erectile dysfunction (ED). Both conditions may share an internal pathologic environment, also known as common soil. Their...
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Hemodynamic and Histopathologic Benefits of Early Treatment with Macitentan in a Rat Model of Pulmonary Arterial Hypertension

Kim KH, Kim HK, Chan SY, Kim YJ, Sohn DW

BACKGROUND AND OBJECTIVES: Macitentan (MAC) reduces morbidity and mortality among advanced-stage pulmonary arterial hypertension (PAH) patients. However, data regarding the histopathologic and hemodynamic benefits of MAC treatment at an early...
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Safety and Efficacy of the Coadministration of Sildenafil and Finasteride

Lee SW, Lee SH, Kim KS, Lee S, Chung JH

PURPOSE: The 5-alpha reductase inhibitors (5ARI) are one of the most commonly used medications for the treatment of benign prostatic hyperplasia (BPH). Phosphodiesterase type-5 inhibitors are also used to treat...
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A Case of Sexual Enhancer Induced Fixed Drug Eruption

Lee SK, Kim DJ, Suh JH, Kim MS, Lee UH

  • KMID: 2436688
  • Korean J Dermatol.
  • 2018 May;56(4):269-272.
Fixed drug eruption is a commonly reported mucocutaneous drug eruption. A 61-year-old male presented to our clinic with a complaint of an itchy round erythematous patch on the left hand...
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A Case of a Visual Field Defect with Optical Coherence Tomography Changes after Sildenafil Citrate Overdose

Park HS, Yang JY, Lee J

PURPOSE: A case of a transient visual field defect and a change in spectral-domain optical coherence tomography (SD-OCT) after an overdose of sildenafil citrate is described. CASE SUMMARY: A 67-year-old male...
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Large Atrial Septal Defect Closure in a Patient with Severe Pulmonary Arterial Hypertension

Supomo S, Hartopo AB, Anggrahini DW, Darmawan H, Dinarti LK

Patients with an atrial septal defect (ASD) and severe pulmonary arterial hypertension (PAH) are considered ineligible for defect closure surgery because of the risk of right ventricular decompensation and death...
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Quercetin Relaxed the Smooth Muscle of Rabbit Penile Corpus Cavernosum by Activating the NO-cGMP Signaling Pathway

Choi BR, Kim HK, Park JK

The aim of this study was to investigate the effect and action mechanism of quercetin on penile corpus cavernosum smooth muscle (PCCSM). PCCSM precontracted with phenylephrine (Phe) was treated with...
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Comparison of pharmacokinetic characteristics of sildenafil citrate chewable tablets and film-coated tablets in healthy male subjects

Yoo H, Cho SM, Choi YW, Lee HJ, Kwon JH, Kim SW, Kim JW, Lee S, Hong JH

UI14SDF100CW is a chewable tablet of sildenafil citrate, which was developed to improve compliance through convenience of administration. The purpose of this study was to compare the pharmacokinetic (PK) properties...
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Fixed Drug Eruption Caused by Sildenafil Citrate

Choi SY, Suh JH, Park KY, Li K, Kim BJ, Seo SJ, Kim MN, Hong CK

No abstract available.
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Validated UPLC-MS/MS method for the determination of tadalafil in human plasma and its application to a pharmacokinetic study

Kim KY, Nam M, Kwon HJ, Kim KH, Kang SH, Kim SI, Kim CW, Cho SH

A simple, rapid, and reliable UPLC-MS/MS method was developed and validated for the determination of tadalafil in human plasma. The plasma samples were deproteinized with acetonitrile. Chromatographic separation was performed...
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Fast Cicatrization of Extensive Livedoid Vasculopathy Ulcers under Treatment with Sildenafil

Lopes LM, Campos GG, Eisenreich MA, Defaveri do Prado A, Bredemeier M

No abstract available.
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The maintenance ability and Ca²⁺ availability of skeletal muscle are enhanced by sildenafil

Huang M, Lee KJ, Kim KJ, Ahn MK, Cho CH, Kim DH, Lee EH

Sildenafil relaxes vascular smooth muscle cells and is used to treat pulmonary artery hypertension as well as erectile dysfunction. However, the effectiveness of sildenafil on skeletal muscle and the benefit...
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A Rare Case of Viagra Induced Toxic Encephalopathy

Jeong SY, Jeon SJ, Kim YR, Choi SS, Kwak HS

Viagra has been prescribed worldwide to treat men with erectile dysfunction. Clinical trials have shown that Viagra may cause various kinds of adverse effects include some central nervous system (CNS)...
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The effect of sildenafil on right ventricular remodeling in a rat model of monocrotaline-induced right ventricular failure

Bae HK, Lee H, Kim KC, Hong YM

PURPOSE: Pulmonary arterial hypertension (PAH) leads to right ventricular failure (RVF) as well as an increase in pulmonary vascular resistance. Our purpose was to study the effect of sildenafil on...
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Population pharmacokinetics and inter-laboratory variability of sildenafil and its metabolite after oral administration in Korean healthy male volunteers

Youn S, Park WS, Park GJ, Jang DY, Bae SH, Han S, Yim DS

This study was to clarify population pharmacokinetics (PK) of sildenafil and its metabolite, N-desmethyl sildenafil (NDS) in Korean healthy male population using a pooled data from multiple clinical trials in...
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Sildenafil Ameliorates Advanced Glycation End Products-Induced Mitochondrial Dysfunction in HT-22 Hippocampal Neuronal Cells

Sung SK, Woo JS, Kim YH, Son DW, Lee SW, Song GS

OBJECTIVE: Accumulation of advanced glycation end-products (AGE) and mitochondrial glycation is importantly implicated in the pathological changes of the brain associated with diabetic complications, Alzheimer disease, and aging. The present...
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Flibanserin for Treating Hypoactive Sexual Desire Disorder

Sang JH, Kim TH, Kim SA

There have been several products developed for male sexual dysfunction. However, developing agents for female sexual dysfunction is lagging behind for various reasons. Sildenafil citrate (Viagra) and Tadalafil (Cialis), which...
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A Case of Transient Color Anomaly and Persistent Visual Field Defect after Sildenafil Citrate Overdose

Kim P, Kim SY

PURPOSE: Sildenafil citrate, is an oral tablet demonstrating efficacy for maintaining an erection in males with erectile dysfunction by inhibiting phosphodiesterase type 5 (PDE5). In the present study, we report...
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