- Conversion of a murine monoclonal antibody A13 targeting epidermal growth factor receptor to a human monoclonal antibody by guided selection
-
Chang KH, Kim MS, Hong GW, Shin YN, Kim SH
- KMID: 1120142
- Exp Mol Med.
- 2012 Jan;44(1):52-59.
- doi: 10.3858/emm.2012.44.1.005
Epidermal growth factor receptor (EGFR) is an attractive target for tumor therapy because it is overexpressed in the majority of solid tumors and the increase in receptor expression levels has... -
- CITED
-
- Close
- SHARE
-
- Close
- Affinity Maturation of an Epidermal Growth Factor Receptor Targeting Human Monoclonal Antibody ER414 by CDR Mutation
-
Chang KH, Kim MS, Hong GW, Seo MS, Shin YN, Kim SH
- KMID: 2424210
- Immune Netw.
- 2012 Aug;12(4):155-164.
It is well established that blocking the interaction of EGFR with growth factors leads to the arrest of tumor growth, resulting in tumor cell death. ER414 is a human monoclonal... -
- CITED
-
- Close
- SHARE
-
- Close
