Ann Lab Med.  2015 Jan;35(1):162-164. 10.3343/alm.2015.35.1.162.

Constitutional Chromosomal Abnormality Identified in a Sibling Donor After Bone Marrow Stem Cell Transplantation in a Pediatric Patient with Acute Megakaryoblastic Leukemia

• Seo BY
• Choi HW
• Kang MG
• Cho D
• Kee SJ
• Kim SH
• Shin JH
• Suh SP
• Ryang DW
• Shin MG

• KMID: 2363169
• DOI: http://doi.org/10.3343/alm.2015.35.1.162

Abstract

No abstract available.

MeSH Terms

Bone Marrow/pathology
*Bone Marrow Transplantation
Child, Preschool
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 2
Humans
Infant
Karyotyping
Leukemia, Megakaryoblastic, Acute/genetics/*therapy
Male
Siblings
Tissue Donors
Translocation, Genetic/*genetics
Transplantation, Homologous

Figure

• 

  Fig. 1 Karyotypic findings in the patient and donor. Conventional cytogenetic analysis from the patient's bone marrow before transplantation (A) and in the peripheral blood after transplantation (B) demonstrated a karyotype of 46,XY,t(2;11)(q32;q23). Conventional cytogenetic analysis from the sibling donor's peripheral blood showed a karyotype of 46,XY,t(2;11)(q32;q23) (C). Mononuclear cells from the sibling donor's peripheral blood showed a constitutional chromosomal aberration of 46,XY,t(2;11)(q32;q23), which was also confirmed by M-FISH analysis (D). Arrows indicate the aberrant chromosomes.

Reference

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