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A Multi-Center, Double-Blind Randomized Controlled Phase III Clinical Trial to Evaluate the Antiviral Activity and Safety of DA-2802 (Tenofovir Disoproxil Orotate) and Viread (Tenofovir Disoproxil Fumarate) in Chronic Hepatitis B Patients

Kim HJ, Kim JH, Yeon JE, Seo YS, Jang JW, Cho YK, Jang BK, Han BH, Lee C, Lee JH, Yoon JH, Kim KM, Kim MY, Kim DY, Park NH, Cho EY, Lee JS, Lee JW, Kim IH, Song BC, Lee BS, Kwon OS

Background: Tenofovir disoproxil fumarate (TDF, Viread® ) had been used as a standard treatment option of chronic hepatitis B (CHB). This clinical trial was conducted to evaluate the efficacy and...
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Two Cases of Cerebral Infarction after Endoscopic Sinus Surgery

Jo KH, Seo YS, Kwon JH, Kim JY

Perioperative stroke is one of the most fatal complications for patients as well as for doctors. It is defined as a brain infarction or hemorrhage, occurring during or within 30...
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Serum milk fat globule-EGF factor 8 protein as a potential biomarker for metabolic syndrome

Lee HA, Lim J, Joo HJ, Lee YS, Jung YK, Kim JH, An H, Yim HJ, Jeen YT, Yeon JE, Lim DS, Byun KS, Seo YS

Background/Aims: Useful biomarkers for metabolic syndrome have been insufficient. We investigated the performance of serum milk fat globule-EGF factor-8 (MFG-E8), the key mediator of inflammatory pathway, in diagnosis of metabolic...
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Direct Bilirubin Is More Valuable than Total Bilirubin for Predicting Prognosis in Patients with Liver Cirrhosis

Lee HA, Jung JY, Lee YS, Jung YK, Kim JH, An H, Yim HJ, Jeen YT, Yeon JE, Byun KS, Um SH, Seo YS

Background/Aims: Most prognostic prediction models for patients with liver cirrhosis include serum total bilirubin (TB) level as a component. This study investigated prognostic performance of serum direct bilirubin (DB) and...
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Identification of Intrathyroidal Parathyroid Gland Using Near-Infrared Autofluorescence and Autotransplantation: Report of Two Cases

Kim CH, Seo YS, Kim SW, Lee KD

For safe thyroidectomy, preservation of the parathyroid gland is mandatory. However, until recently, there has been no reliable method of identifying the parathyroid glands. Thus, the identification of the parathyroid...
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Novel Ablation Therapy Using Endoscopic Irreversible Electroporation in the Bile Duct: A Pilot Animal Study

Lee KW, Lee JM, Choi HS, Kim ES, Keum B, Seo YS, Jeen YT, Um SH, Lee HS, Chun HJ, Kim CD, Oh CH, Kim HB

Background/Aims: Irreversible electroporation (IRE) is a relatively new ablation method. However, the application of IRE ablation in the treatment of biliary disease has not been attempted. A minimally invasive approach...
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Change in the Recurrence Pattern and Predictors over Time after Complete Cure of Hepatocellular Carcinoma

Lee HA, Lee YS, Kim BK, Jung YK, Kim SU, Park JY, Kim JH, An H, Kim DY, Yim HJ, Ahn SH, Yeon JE, Byun KS, Han KH, Um SH, Seo YS

Background/Aims: We investigated changes in recurrence rates and significant recurrence predictors over time after complete cure of hepatocellular carcinoma (HCC). Methods: A total of 1,491 patients with first-time diagnosis of Barcelona...
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Early Retinal Hemorrhage Absorption Rate and Long Term Clinical Outcomes in Branch Retinal Vein Occlusion

Kim YB, Lee CH, Shin YK, Kyung SE, Seo YS

Purpose: We report the relationship between early retinal hemorrhage absorption rate (RHAR) and long-term clinical outcomes associated with branch retinal vein occlusion (BRVO). Methods: This retrospective study included 66 eyes with...
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Celecoxib, a selective cyclooxygenase-2 inhibitor, aggravates radiation-induced intestinal damage in mice

Lee S, Chun JM, Lee JH, Seo YS, Park JH, Lee HJ, Moon C, Kim SH, Kim JS

Celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, was approved as a non-steroidal anti-inflammatory drug (NSAID), and this therapeutic application has been expanded to several other diseases, including colon cancer. Notably, a...
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Thermoluminescent dosimetry of panoramic radiography

Seo YS, Yu SK

This study aims to calibrate a thermoluminescence dosimeter (TLD) using a diagnostic radiation device and evaluate the dose of panoramic radiography. TLD-100s were calibrated using a solid-state dosimeter (Unfors Mult-O-Meter...
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Comparison of Sorafenib versus Hepatic Arterial Infusion Chemotherapy-Based Treatment for Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis

Ahn YE, Suh SJ, Yim HJ, Seo YS, Yoon EL, Kim TH, Lee YS, Yim SY, Kim HR, Kang SH, Jung YK, Kim JH, Yeon JE, Um SH, Byun KS

Background/Aims: Sorafenib is the first approved systemic treatment for advanced hepatocellular carcinoma (HCC). However, its clinical utility is limited, especially in Asian countries. Several reports have suggested the survival benefits...
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Role of tenofovir disoproxil fumarate in prevention of perinatal transmission of hepatitis B virus from mother to child: a systematic review and metaanalysis

Lee YS, Lee HS, Kim JH, Chang SW, Hyun MH, Bak H, Kim S, Lee Mj, Lee CU, Jung YK, Seo YS, Yim HJ, Yeon JE, Um SH, Byun KS

Background/Aims: To prevent the perinatal transmission of hepatitis B virus (HBV) from mother to child, administration of an antiviral agent during pregnancy has been attempted in women who are either...
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Age estimation by pulp/tooth area ratio in a Korean sample on digital panoramic radiographs

Roh BY, Kim CG, Lee SS, Lee WJ, Seo YS, Ryu JW, Ahn JM, Yoon CL

Age estimation based on the change in the size of the pulp due to secondary dentin deposition can be conducted non-invasively using radiographic photographs. Among these methods, age estimation using...
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Usefulness of Autofluorescence Video-Monitoring to Enhanced Localization of Parathyroid Glands

Kim SW, Seo YS, Lee HS, Kim Y, Ahn YC, Lee KD

Background and Objectives Near-infrared (NIR) fluorescence photo imaging provides real time parathyroid anatomy enhancement. Moreover, autofluorescence enables intraoperative virtual reality parathyroid exploration of the optical characteristics of the parathyroid gland....
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Effects of 10-Week Body Stability Exercise Program on Functional Movement and Body Balance of Middle School Volleyball Players

Song IY, Seo YS, Kang YH

Purpose: This study examined the effects of a physical stability exercise program on the functional movement and balance of middle school volleyball players to provide future management and training data...
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Minimally Invasive Gastric Electrical Stimulation Using a Newly Developed Wireless Gastrostimulator: A Pilot Animal Study

Kim SH, Kim HB, Chun HJ, Choi HS, Kim ES, Keum B, Seo YS, Jeen YT, Lee HS, Um SH, Kim CD

  • KMID: 2504010
  • J Neurogastroenterol Motil.
  • 2020 Jul;26(3):410-416.
  • doi: 10.5056/jnm20063
Background/Aims Gastric electrical stimulation (GES) is a feasible modality for the treatment of gastroparesis; however, the presently available device requires invasive surgical implantation for long-term stimulation and repeated surgical procedure...
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Current Status of Systemic Therapy in Hepatocellular Carcinoma

Lee HA, Seo YS

  • KMID: 2503589
  • J Dig Cancer Rep.
  • 2020 Jun;8(1):65-70.
Although being one of the major causes of malignancy related death globally, hepatocellular carcinoma (HCC) has not received much attention in respect of novel drug development. Fortunately, several new drugs...
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Oxysterol 25-hydroxycholesterol as a metabolic pathophysiological factors of osteoarthritis induces apoptosis in primary rat chondrocytes

Seo YS, Cho IA, Kim TH, You JS, Oh JS, Lee GJ, Kim DK, Kim JS

The aim of the present study was to investigate the pathophysiological etiology of osteoarthritis that is mediated by the apoptosis of chondrocytes exposed to 25-hydroxycholesterol (25-HC), an oxysterol synthesized by...
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Differential Impact of Serum 25-Hydroxyvitamin D3 Levels onthe Prognosis of Patients with LiverCirrhosis According to MELD andChild-Pugh Scores

Kim TH, Yun SG, Choi J, Goh HG, Lee HA, Yim SY, Choi SJ, Lee YS, Yoon EL, Jung YK, Seo YS, Kim JH, Yim HJ, Yeon JE, Byun KS, Um SH

Background: Prognosis of patients with diverse chronic diseases is reportedly associated with 25-hydroxyvitamin D levels. In this study, we investigated the potential role of 25-hydroxyvitamin D3 (25[OH]D3) levels in improving...
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Associations between Nutritional Risk and Mental Health in an Elderly Korean Population

Kim SJ, Kim IG, Jung DU, Park JH, Seo YS, Moon JJ, Jeon DW

  • KMID: 2500623
  • J Korean Geriatr Psychiatry.
  • 2020 Apr;24(1):28-36.
Objective:Older adults are at greater risk for malnutrition than younger adults, and malnutrition can be associated with a variety of mental problems. This study was undertaken to investigate differences in...
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