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The Expression of Toll-like Receptors in Idiopathic Inflammatory Myopathies

Kim GT, Lee JH, Baek SH, Lee JW, Cho MR, Kim JI, Lee SH, Kim DS, Kim SI

Objective: To investigate the expression of toll-like receptor (TLR)-2, 4 and 9 in idiopathic inflammatory myopathies (IIMs). Methods: The expression of TLR-2, 4 and 9 was measured by real-time RT-PCR and...
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Cap Myopathy With a Heterozygous TPM3 Missense Mutation

Jung Y, Park YE, Shin JH, Lee CH, Kim DS

Cap myopathy is pathologically characterized by cap structures comprising well-demarcated areas under the sarcolemma and containing deranged myofibrils and scattered Z-disks. Clinically it presents with slowly progressive muscle weakness, myopathic...
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A Case of Nemaline Myopathy

Kim BJ, Choi IJ, Kim DS, Nam SO

  • KMID: 2207358
  • J Korean Pediatr Soc.
  • 2001 Oct;44(10):1182-1186.
Childhood onset nemaline myopathy, first described in 1963 by Shy, et al and Conen, et al, is rare congenital myopathy, characterized by nonprogressive or slowly progressive muscle weakness associated with...
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CD36 (SR-B2) as a Target to Treat Lipid Overload-Induced Cardiac Dysfunction

Glatz JF, Luiken JJ, Nabben M

The heart faces the challenge of adjusting the rate of fatty acid uptake to match myocardial demand for energy provision at any given moment, avoiding both too low uptake rates,...
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Molecular and Pathological Diagnosis of Muscular Dystrophies

Choi YC

  • KMID: 2053704
  • Hanyang Med Rev.
  • 2006 Feb;26(1):77-93.
The muscular dystrophies are a diverse group of inherited muscle disorders characterized by progressive muscle weakness and wasting with characteristic histologic abnormalities such as degeneration, necrosis, and regeneration of muscle...
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The Effect of L-Carnitine Supplementation on the Dystrophic Muscle and Exercise Tolerance of Muscular Dystrophy (mdx) Mice

Oh J, Kang HJ, Kim HJ, Lee JH, Choi KG, Park KD

  • KMID: 2185344
  • J Korean Neurol Assoc.
  • 2005 Aug;23(4):519-527.
BACKGROUND: Duchenne muscular dystrophy is an X-linked recessive disorder leading to death in the late teens or early twenties. There is no effective pharmacological therapy for now. L-carnitine (LCAR), a...
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Effects of Pentobarbital on Granularity of Rat Atrial Cardiocyte

Seon YD, Lee TH, Nam KI, Park SS

  • KMID: 1973073
  • Chonnam Med J.
  • 1996 Jun;32(1):13-24.
The present study examined a long-term effect of pentobarbital anesthesia on the granularity of atrial cardiocyte in rats. The male and female rats were used separately and the animals were...
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The Study on the Na(+), K(+)-ATPase Activities of the Spontaneously Hypertensive Rats

Won KH, Kyoung NH, Hah JS, Kim KJ

Although the mechanism of the development of hypertension has not been fully elucidated, abnormal ion transport across the cardiovascular musle membrance may play some role in this mechanism. The elevation...
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Effect of Cadmium Chloride on the Cardiac Muscle Ultrastructure in Rats

Lee BH, Kim KS, Kim JH, Lim HK, Lee CK, Shin SH, Kim SK

BACKGROUND: Cadmium, an environmental pollutant, has implicated in the pathogenesis of cardiovascular diseases. Biochemical and pathophysiological changes characterized by arterial hypertension, accelerated cholesterol plaque formation on arterial walls, cardiac conduction...
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Modulation of Severity of Relaxation in the Isolated Rat Aortic Tissue Model of Ischemia

Kim WO, Kil HK, Kim JH, Park YS

The purpose of this study was undertaken to test if alteration of calcium flux across the sarcolemma or sarcoplasmic reticulum change subsequent relaxation of rat aorta in tissue model of...
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Dysferlin Expression in Skeletal muscles of Patients with Myopathy and Cultured Human Myoblast/Myotube

Lee EY, Choi YC

  • KMID: 2343291
  • J Korean Neurol Assoc.
  • 2007 Nov;25(4):521-529.
BACKGROUND: Dysferlin is a 230 kDa protein of the sarcolemma. This encoding gene is mutated in patients with dysferlinopathy (limb-girdle muscular dystrophy 2B and Miyoshi myopathy), which is characterized byan...
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The Effect of Nicardipine on Capacitative Calcium Entry in Canine Pulmonary Arterial Smooth Muscle Cells

Yeom JH, Shin HI, Shim JH, Jeon WJ, Cho SY, Shin WJ, Kim KH

BACKGORUND: Capacitive calcium entry involves the influx of Ca2+ across the sarcolemma in response to the depletion of intracellular Ca2+ stores. Presently, little is known about the nature...
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notropic and Electrophysiologic Effect of Azumolene in Intact Myocardium In Vitro

Park WK, Kim KJ, Kim JH, Hong SJ

BACKGROUND: The effects of various concentrations (10, 25 micrometer) of azumolene, an analogue of dantrolene, were studied in isolated guinea pig ventricular papillary muscles by measuring the effects on myocardial...
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The Effect of Magnesium on the Verapamil Neuromuscular Blockade in Rat Phrenic Nerve-Hemidiaphragm Preparations

Lee SI, Lee JH, Kim DY, Kim JY

BACKGROUND: At the neuromuscular junction, magnesium acts on the release of acetylcholine and on the excitability of sarcolemma. Verapamil inhibits acetylcholine release and enhances the autodesensitization of acetylcholine receptor ion...
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Mn-SOD Immunoreactivities of Rectus Femoris Muscle of the Rat in Reperfusion Injury and the Effects of Alopurinol Pretreatment

Hwang CW, Choi DH, Jo GR, Paik DJ

  • KMID: 2322498
  • J Korean Soc Plast Reconstr Surg.
  • 1999 Mar;26(2):245-251.
It has been well known that ischemia reperfusion injury to skeletal muscle following an acute arterial occlusion causes significant morbidity and mortality. There are many causes of reperfusion injury, but...
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Mercury Promotes Catecholamines Which Potentiate Mercurial Autoimmunity and Vasodilation: Implications for Inositol 1,4,5-Triphosphate 3-Kinase C Susceptibility in Kawasaki Syndrome

Yeter D, Deth R, Kuo HC

Previously, we reviewed biological evidence that mercury could induce autoimmunity and coronary arterial wall relaxation as observed in Kawasaki syndrome (KS) through its effects on calcium signaling, and that inositol...
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