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Population pharmacokinetics of vedolizumab in Asian and non-Asian patients with ulcerative colitis and Crohn’s disease

Okamoto H, Dirks NL, Rosario M, Hori T, Hibi T

Background/Aims: Vedolizumab is indicated for moderately-to-severely active ulcerative colitis (UC) and Crohn’s disease (CD). Because multiple factors may result in different pharmacokinetics and clinical efficacies, understanding determinants of vedolizumab clearance...
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Cervical Spondylotic Myelopathy: World Federation of Neurosurgical Societies (WFNS) to the Italian Neurosurgical Society (SINch) Recommendations

Costa F, Anania CD, Agrillo U, Roberto A, Claudio B, Simona B, Daniele B, Carlo B, Barbara C, Ardico C, Battista CG, Raffaele DF, Andrea DR, Carlo DV, Mauro D, Vito F, Diego G, Giancarlo G, Corrado I, Claudio I, Michele I, Innocenzi G, Alessandro L, Giancarlo L, Giuseppe M, Ciro M, Rosario M, Vincenzo M, Nicola M, Pierpaolo N, Andrea P, Giovanni P, Federico PP, Armando R, Alessandro R, Rossella R, Stefano R, Sbaffi PF, Teresa S, Enrico T, Matteo V, Zerbi A, Gianluigi Z, Barbanera A, the SINch Spine Section Group

Cervical spondylotic myelopathy (CSM) is a progressively growing pathology to afford by a spinal surgeon due to the aging of the population, associated with better treatment management and the best...
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