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Antiproliferative effect of basic fibroblast growth factor-saporin mitotoxin on keratocytes in culture

Wee WR, Parandoosh Z, Sakamoto T, Caton M, Nova M, McDonnell

We evaluated the effect of the conjugate of basic fibroblast growth factor (FGF2) and saporin (FGF2-SAP) on proliferation of cultured keratocytes. Cultured rabbit and human keratocytes were incubated in medium...
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Thermo-stability and antitumor activity on colon cancer cell lines of monoclonal anti-CEA antibody-saporin immunotoxin

Manosroi J, Kleist SV, Manosroi A, Grunert F

Eight saporin peaks were obtained from the purification of seed extracts of Saponaria officinalis L. Saporin peak No. 6 (SAP-6) showed the highest activity in the inhibition of protein...
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Basal Forebrain Cholinergic Deficits Reduce Glucose Metabolism and Function of Cholinergic and GABAergic Systems in the Cingulate Cortex

Jeong DU, Oh JH, Lee JE, Lee J, Cho ZH, Chang JW, Chang WS

PURPOSE: Reduced brain glucose metabolism and basal forebrain cholinergic neuron degeneration are common features of Alzheimer's disease and have been correlated with memory function. Although regions representing glucose hypometabolism in...
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