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Influence of conventional house-dust-mite immunotherapy on histamine releasability from the basophil

Shim JY, Kim BS, Cho SH, Min KU, Hong SJ

  • KMID: 2054868
  • J Asthma Allergy Clin Immunol.
  • 2000 Oct;20(5):731-740.
BACKGROUND: Allergen-specific immunotherapy has been shown to be clinically effective in the treatment of patients with atopic asthma, but the mechanisms are still unclear. Some of the immunologic changes include...
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Effects of anti-IgE mAb on serum IgE, Fc epsilon RII/CD23 expression on splenic B cells and worm burden in mice infected with Paragonimus westermani

Shin MH, Min HK

It is generally accepted that parasite-specific IgE plays a crucial role in host defense against helminthic parasites. However, the role of high levels of nonspecific IgE in helminthic infections is...
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Studies on the role of interleukin-4 and Fc epsilon RII in the pathogenesis of minimal change nephrotic syndrome

Cho BS, Lee CE, Pyun KH

Childhood minimal change nephrotic syndrome (MCNS) has often been associated with allergic symptoms such as urticaria, bronchial asthma, atopic dermatitis, allergic rhinitis and elevated IgE levels and referred to...
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FCepsilonRI Gene Promoter Polymorphisms and Total IgE Levels in Susceptibility to Atopic Dermatitis in Korea

Park KY, Park MK, Kim EJ, Lee MK, Seo SJ

IgE-dependent activation of mast cells and basophils through the high-affinity IgE receptor (FcepsilonRI) is involved in the pathogenesis of allergen-induced immune responsiveness in atopic diseases like atopic dermatitis (AD). We...
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Antibody to FcεRIα Suppresses Immunoglobulin E Binding to High-Affinity Receptor I in Allergic Inflammation

Hong JY, Bae JH, Lee KE, Kim M, Kim MH, Kang HJ, Park EH, Yoo KS, Jeong SK, Kim KW, Kim KE, Sohn MH

PURPOSE: High-affinity receptor I (FcεRI) on mast cells and basophils plays a key role in the immunoglobulin E (IgE)-mediated type I hypersensitivity mediated by allergen cross-linking of the specific IgE-FcεRI...
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Identifying Genetic Susceptibility to Sensitization to Cephalosporins in Health Care Workers

Nam YH, Kim JE, Kim SH, Jin HJ, Hwang EK, Shin YS, Ye YM, Park HS

Exposure to cephalosporins could cause occupational allergic diseases in health care workers (HCWs). We evaluated the prevalence of serum specific IgE and IgG antibodies to cephalosporin-human serum albumin (HSA) conjugate...
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Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist's Perspective

Jang TY, Kim YH

Interleukin (IL) 33, a member of the IL-1 superfamily, is an "alarmin" protein and is secreted in its active form from damaged cells undergoing necrotic cell death. Mast cells are...
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Polymorphisms of High-Affinity IgE Receptor and Histamine-Related Genes in Patients with ASA-Induced Urticaria/Angioedema

Choi JH, Kim SH, Suh CH, Nahm DH, Park HS

The pathogenic mechanism of ASA-induced urticaria/angioedema (AIU) is still poorly understood, but it has been known that histamine releasing by cutaneous mast cell activation is considered to be an important...
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CD23(FcepsilonRII) Expression on Splenic B Cells in Paragonimus Westermani-infected Mice

Shin MH

OBJECT: Elevation of serum lgE is the most characteristic immune response in helminthic infections. Recently, expression of CD23(FcepsilonRII on B lymphocytes play a major role in lgE production in allergic...
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Increased Level of Basophil CD203c Expression Predicts Severe Chronic Urticaria

Ye YM, Yang EM, Yoo HS, Shin YS, Kim SH, Park HS

Increased FcepsilonR1alpha expression with upregulated CD203c expression on peripheral basophils is seen in patients with chronic urticaria (CU). However, there has been no published report on the association between CD203c...
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Updated treatment guideline of chronic spontaneous urticaria

Roh JY

Chronic spontaneous urticaria (CSU), also known as chronic idiopathic urticaria, is a common chronic inflammatory skin disorder that has a prevalence of 0.5% to 1% in the general population. It...
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Changes of Serum Cytokines After the Long Term Immunotherapy with Japanese Hop Pollen Extracts

Ye YM, Lee SK, Kim SH, Nahm DH, Suh CH, Park HS

Japanese hop (Hop J) pollen has been considered as one of the major causative pollen allergens in the autumn season. We developed a new Hop J immunotherapy extract in collaboration...
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