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The role of spinal adrenergic receptors on the antinociception of ginsenosides in a rat postoperative pain model

Kim IJ, Park CH, Lee SH, Yoon MH

BACKGROUND: The effect of spinal adrenergic and cholinergic receptors on the anti-nociceptive effect of intrathecal ginsenosides was determined in a rat postoperative pain model. METHODS: Catheters were placed into the intrathecal...
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Effects in Lumen Width of Nasolacrimal Drainage System After Adrenergic Drug Irrigation

Kim YM, Oh DE

  • KMID: 2337851
  • J Korean Ophthalmol Soc.
  • 2010 Aug;51(8):1039-1046.
PURPOSE: The lacrimal sac and nasolacrimal duct are surrounded by a wide cavernous system of veins and arteries, and the blood vessels of the cavernous body are innnervated by the...
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G-protein Effects on [ 3H]RX821002 Binding to Alpha-2 Adrenoceptor in Rat Brain

Chung IW, Shin JY, Shin CJ

  • KMID: 1985334
  • Korean J Psychopharmacol.
  • 2001 Dec;12(4):301-309.
OBJECTIVE: This study is to explore the effects on specific bindings between [ 3H]RX821002, alpha-2 adrenergic receptor antagonist and alpha-2 adrenergic receptor in rat brain by G-protein modulation. METHODS: The radioligand...
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Antiallodynic effects of intrathecal tianeptine in a neuropathic pain rat

Lin H, Lee HG, Yoon MH

  • KMID: 1797467
  • Anesth Pain Med.
  • 2014 Apr;9(2):93-97.
BACKGROUND: Tianeptine is an antidepressant drug which is used for treating depression. Interestingly, the tianeptine has shown antinociceptive effects within a variety of nociceptions. The aim of this study is...
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Effects of Clonidine and Yohimbine on Neuropathic Pain in a Rat Model

Yang JH, Song EB, Kim SJ, Lee SH, Na HS

  • KMID: 2323478
  • J Korean Acad Rehabil Med.
  • 2000 Aug;24(4):587-593.
OBJECTIVE: In a rat model of peripheral neuropathy, to determine whether neuropathic pain is related to the alpha-2 adrenergic receptor. METHOD: The neuropathic pain was produced by unilateral transection of the...
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Renal sympathetic nerve activation via α₂-adrenergic receptors in chronic kidney disease progression

Jang HS, Kim J, Padanilam

Chronic kidney disease (CKD) is increasing worldwide without an effective therapeutic strategy. Sympathetic nerve activation is implicated in CKD progression, as well as cardiovascular dysfunction. Renal denervation is beneficial for...
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Regional Brain Perfusion before and after Treatment with Methylphenidate According to the MspI Polymorphism of the Alpha-2A Adrenergic Receptor Gene in Children with Attention-Deficit Hyperactivity Disorder

Park S, Bae JH, Kim JW, Yang YH, Oh S, Hong SB, Park MH, Kim BN, Shin MS, Yoo HJ, Cho SC

  • KMID: 2291635
  • J Korean Acad Child Adolesc Psychiatry.
  • 2013 Mar;24(1):21-27.
OBJECTIVES: Dysregulation of the central noradrenergic system may be involved in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). The aim of this study was to examine the differences in pre-...
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The Effect of Brimonidine on Transepithelial Resistance in a Human Retinal Pigment Epithelial Cell Line

Park JH, Kim SJ, Yu HG

PURPOSE: To investigate the effects of brimonidine, an alpha-2-adrenergic agonist, on barrier function in ARPE-19 cells by measuring transepithelial resistance (TER). METHODS: ARPE-19 cells were cultured into a confluent monolayer...
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Genetic Variations in Attention Deficit Hyperactivity Disorder Subtypes and Treatment Resistant Cases

Unal D, Unal MF, Alikasifoglu M, Cetinkaya

OBJECTIVE: ObjectiveaaWe evaluated the distribution of alpha-2A adrenergic receptor (ADRA2A) and catechol-o-methyltransferase (COMT) single nucleotide polymorphisms (SNPs) among ADHD subtypes and other homogeneous patient populations including treatment-resistant cases and patients...
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The Alpha-2A Adrenergic Receptor Gene -1291C/G Single Nucleotide Polymorphism is Associated with the Efficacy of Methylphenidate in Treating Taiwanese Children and Adolescents with Attention-Deficit Hyperactivity Disorder

Huang HC, Wu LS, Yu SC, Wu BJ, Lua AC, Lee SM, Liu CZ

OBJECTIVE: The therapeutic effect of methylphenidate (MPH) in treating attention-deficit/hyperactivity disorder (ADHD) has been related to the alpha-2A adrenergic receptor (ADRA2A) gene -1291C/G single nucleotide polymorphism (SNP). We investigated the...
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Hemodynamic and Analgesic Effects of Intrathecal Clonidine and Neostigmine on Bupivacaine Spinal Anesthesia in Patients Undergoing Cesarean Section

Cho HY, Jang SY, Han YJ, Choe H, Kim DC

BACKGROUND: Clonidine is well known to stimulate both peripheral and central alpha-2 adrenergic receptors. After intrathecal administration, a marked analgesic effect and side effects of hypotension, bradycardia, sedation and dryness...
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Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro

Kim JW, Kang KW, Oh GT, Song J, Kim ND, Pak YK

  • KMID: 1081463
  • Exp Mol Med.
  • 2002 May;34(2):137-144.
Cholesterol-rich diet impairs endothelial NO synthase (eNOS) and enhances inducible NOS (iNOS) expression. In this study, we investigated effects of cholesterol on iNOS expression in high-fat-fed rat models, HepG2 and...
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