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Adiponectin for the treatment of diabetic nephropathy

Lee JY, Yang JW, Han BG, Choi SO, Kim JS

The metabolic burden caused by hyperglycemia can result in direct and immediate metabolic injuries, such as oxidative stress and tissue inflammation, in the kidney. Furthermore, chronic hyperglycemia can lead to...
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Expression of Leptin, Leptin Receptor, Adiponectin, and Adiponectin Receptor in Ductal Carcinoma In Situ and Invasive Breast Cancer

Jeong YJ, Bong JG, Park SH, Choi JH, Oh HK

PURPOSE: Adipocytokines, such as leptin, resistin, and adiponectin, are associated with obesity and breast cancer. Several studies have indicated that adipocytokines may influence tumor growth or differentiation. The aims of...
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The Expression of Adiponectin Receptors and the Effects of Adiponectin and Leptin on Airway Smooth Muscle Cells

Shin JH, Kim JH, Lee WY, Shim JY

PURPOSE: Obesity is a major risk factor for asthma and it influences airway smooth muscle function and responsiveness. Adiponectin is inversely associated with obesity and its action is mediated through...
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Role of Soluble Adiponectin Receptor 2 in Non-Alcoholic Fatty Liver Disease in Children

Aksoy GK, Artan R, Aksoy C, Özdem S, Atalay A, Yılmaz A

PURPOSE: The incidence of non-alcoholic fatty liver disease (NAFLD) in children is gradually increasing. The aim of this study was to investigate the use of serum adiponectin and soluble adiponectin...
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Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity

Okada-Iwabu M, Iwabu M, Ueki K, Yamauchi T, Kadowaki T

Obesity associated with unhealthy diet and lack of exercise is shown to contribute to the onset and/or aggravation of the metabolic syndrome and diabetes, thus placing affected individuals at increased...
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The Effects of Antidepressants on the Leptin, Adiponectin, and Adiponectin Receptor mRNA Expression in Model Diabetogenic Rats

Joe KH, Lee HJ, Kim DJ, Lee YS, Kee BS

  • KMID: 2341722
  • J Korean Neuropsychiatr Assoc.
  • 2010 Mar;49(2):217-225.
OBJECTIVES: Weight gain and glucose intolerance are the most common symptoms of metabolic syndrome. Certain patients complain of weight-change and hyperglycemia after receiving antidepressants. Our study evaluated the effects of...
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Synergy between adiponectin and interleukin-1beta on the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in fibroblast-like synoviocytes

Lee YA, Choi HM, Lee SH, Yang HI, Yoo MC, Hong SJ, Kim KS

  • KMID: 1397448
  • Exp Mol Med.
  • 2012 Jul;44(7):440-447.
To determine whether adiponectin may have synergistic effects in combination with the proinflammatory cytokine interleukin (IL)-1beta regarding the production of proinflammatory mediators during arthritic joint inflammation, synovial cells from rheumatoid...
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Streptozotocin-induced Diabetes Increases the Adiponectin-mediated AMP-activated Protein Kinase Cascade in the Hippocampus of Mice

Yi CO, Jeon BT, Kim YH, Jung TS, Lee DH, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS

  • KMID: 1472486
  • Korean J Anat.
  • 2009 Sep;42(3):141-147.
Adiponectin is an adipocyte-derived protein with anti-diabetic and anti-angiogenesis properties that improves both glucose metabolism and insulin resistance via the adenosine monophosphate-activated protein kinase (AMPK) cascade. Diabetic cognitive deficits are...
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Effect of globular adiponectin on interleukin-6 and interleukin-8 expression in periodontal ligament and gingival fibroblasts

Park HG, Bak EJ, Kim JH, Lee YS, Choi SH, Cha JH, Yoo YJ

PURPOSE: Globular adiponectin (gAd) is a type of adipocytokine, which is mainly produced by adipose tissue. It has been reported that gAd acts as a pro- as well as an...
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Association of ADIPOR1 polymorphisms with bone mineral density in postmenopausal Korean women

Kim HY, Hwang JY, Han BG, Lee JY, Park EK, Kim BJ, Lee SH, Kim GS, Kim SY, Koh JM

  • KMID: 1383802
  • Exp Mol Med.
  • 2012 Jun;44(6):394-402.
Adiponectin may affect bone through interactions with two known receptors, adiponectin receptors (ADIPOR) 1 and 2. We examined the association between polymorphisms of ADIPOR1 and ADIPOR2 and bone mineral density...
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Peroxisome Proliferator-Activated Receptor-Gamma Expression in the Lung Tissue of Obese Rats

Hwang SJ, Kim JH, Shim JW, Kim DS, Jung HL, Park MS, Lee WY, Kim SY, Shim JY

PURPOSE: Obesity is a risk factor for asthma and type II diabetes. Peroxisome proliferator-activated receptor (PPAR)-gamma has been suggested to regulate inflammatory responses in diabetes and asthma. We investigated whether...
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