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Virtual Screening for Potential Inhibitors of NS3 Protein of Zika Virus

Sahoo M, Jena L, Daf S, Kumar S

Zika virus (ZIKV) is a mosquito borne pathogen, belongs to Flaviviridae family having a positive-sense single-stranded RNA genome, currently known for causing large epidemics in Brazil. Its infection can cause...
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Role of the PLA2-Activated Neutrophilic Oxidative Stress in Oleic Acid-Induced Acute Lung Injury

Lee YM, Kim BY, Park YY

BACKGROUND: The underlying pathogenesis of fat embolism-induced acute lung injury (ALI) has not been elucidated. In the present study, the pathogenesis of fat embolism-induced ALI was probed in association with...
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Ischemia/reperfusion Lung Injury Increases Serum Ferritin and Heme Oxygenase-1 in Rats

Park YY

Intestinal ischemia/reperfusion (I/R) is one of common causes of acute lung injury (ALI). Early and accurate diagnosis of patients who are like to develop serious acute respiratory distress syndrome (ARDS)...
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STAT3 is involved in phosphatidic acid-induced Bcl-2 expression in HeLa cells

Choi HJ, Lee JH, Park SY, Cho JH, Han JS

Phosphatidic acid (PA), the product of a PLD-mediated reaction, is a lipid second messenger that participates in various intracellular signaling events and is known to regulate a growing list of...
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Update Treatment of Dementia: Focus on Pharmacologic Treatment

Lee KJ

  • KMID: 1481936
  • J Korean Geriatr Psychiatry.
  • 2008 Jun;12(1):17-27.
Dementia is an increasingly common diagnosis in our population, and the numbers are expected to rise exponentially in coming years. Within the past decades research has progressed rapidly on multiple...
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Changes of Serum Ferritin in Acute Lung Injury Induced by Intestinal Ischemia/Reperfusion

Park SD, Park YY

  • KMID: 1587396
  • Korean J Physiol Pharmacol.
  • 2006 Aug;10(4):187-191.
Serum ferritin levels are increased in subjects at-risk for or with acute lung injury (ALI), and there are observations to suggest that increases in serum ferritin levels may help predict...
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The Role of ATP on Reactive Oxygen Species Generation and Cellular Proliferation in BV-2 Cells

Kim YH, Cho JK, Huh PW, Lim Y, Rha HK, Whang KT

  • KMID: 2007391
  • J Korean Child Neurol Soc.
  • 2003 Nov;11(2):238-248.
PURPOSE: Adenosine triphosphate (ATP) evokes several cellular responses in microglia including propagation. However, the role of the purinoceptor on ROS generation in microglia is unclear. In order to determine the...
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Phospholipase A2 Contributes to Hemorrhage-induced Acute Lung Injury Through Neutrophilic Respiratory Burst

Jang YS, Kim SE, Jheon SH, Shin TR, Lee YM

BACKGROUND: The present study was carried out in association with neutrophilic respiratory burst in the lung in order to clarify the pathogenesis of acute respiratory distress syndrome(ARDS) following acute severe...
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Inhibition of Phospholipase A2 Ameliorates the Acute Lung Injury Induced by E Coli Endotoxin via Reduced Production of Oxygen Free Radicals in the Lung

Roh WS, Koo BU, Lee YM

BACKGROUND: In order to understand the pathogenetic mechanism of sepsis-induced acute lung injury, inhibition of phospholipase A2 (PLA A2) was carried out in an endotoxin-induced septic lung model. METHODS: Sprague-Dawley rats...
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Effect of the inhibition of PLA2 and PAF on the neutrophilic respiratory burst and apoptosis

Lee YM, Kim SG, Park YY

BACKGROUND: Since the exact pathogenesis of sepsis-induced ARDS has not been elucidated, the mechanisms of enhanced neutrophilic respiratory burst were probed in endotoxin primed neutrophils associated with the roles of...
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Endotoxin-induced acute lung injury is mediated by PAF produced via remodelling of lyso PAF in the lungs

Lee YM, Kim T

  • KMID: 1580808
  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):219-226.
In order to elucidate the role of platelet activating factor (PAF) in the acute lung injury induced by endotoxin (ETX), activities of phospholipase A2, lyso PAF acetyltransferase and oxidative stress by neutrophilic respiratory...
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Clinical and Cytogenetic Features in Turner Syndrome

Choi YM, Jee BC, Choe J, Oh SK, Hwang DY, Suh CS, Kim SH, Kim JG, Moon SY, Lee YH, Lee JY

  • KMID: 2261845
  • Korean J Obstet Gynecol.
  • 2000 Feb;43(2):295-301.
OBJECTIVE: To identify cytogenetic diversity of Turner syndrome, and its correlation with clinical manifestation including fertility. METHOD: From 1986 to 1996, we reviewed medical records of 137 patients, cytogenetically and...
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Effect of the inhibition of phospholipase A2 in generation of free radicals in intestinal ischemia/reperfusion induced acute lung injury

Lee YM, Park YY, Kim T, Cho HG, Lee YJ, Repine JE

  • KMID: 2285220
  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):263-273.
The role of phospholipase A2 (PLA2) in acute lung leak induced by intestinal ischemia was investigated in association with neutrophilic respiratory burst. To induce lung leak, we generated intestinal ischemia for 60 min...
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Role of phospholipase A2 in hypoxia-induced renal cell injury

Choi WR, Ko SH, Cho SI, Woo JS, Jung JS, Lee SH, Kim YK

  • KMID: 1917075
  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):93-100.
The present study was designed to assess the roles of PLA2 activation and arachidonic acid (AA) metabolites in hypoxia-induced renal cell injury. Hypoxia increased LDH release in a dose-dependent manner in rabbit renal...
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Effect of the inhibition of PLA 2 on oxidative lung injury induced by interleukin-1alpha

Lee YM, Cho HG, Park YY, Kim JK, Lee YJ, Park WH, Kim T

  • KMID: 2071542
  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):617-628.
In order to understand the pathogenetic mechanism of adult respiratory distress syndrome (ARDS), the role of phospholipase A2 (PLA2) in association with oxidative stress was investigated in rats. Interleukin-1alpha (IL-1, 50 mug/rat) was...
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Role of phospholipase A2 in oxidant-induced alteration in phosphate transport in primary cultured rabbit renal proximal tubule cells

Park KM, Ko SH, Woo JS, Jung JS, Lee SH, Kim YK

  • KMID: 2071540
  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):601-609.
The present study was undertaken to examine the role of phospholipase A2 (PLA2) in oxidant-induced inhibition of phosphate transport in primary cultured rabbit renal proximal tubule cells. Uptakes of phosphate and glucose were...
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Mediation of intracellular Ca2+ in the phospholipase A2-induced cell proliferation in human neuroblastoma cells

Kim JA, Lee YS

  • KMID: 2285203
  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):411-417.
The role of phospholipase A2 (PLA2) in tumor cell growth was investigated using SK-N-MC human neuroblastoma cells. 4-Bromophenacyl bromide (BPB) and mepacrine (Mep), known PLA2 inhibitors, suppressed growth of the tumor cells in...
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Regulatory mechanisms of angiotensin II on the Na+/H+ antiport system in rabbit renal proximal tubule cells. II. Inhibitory effects of ANG II on Na+ uptake

Han HJ, Park SH, Koh HJ

  • KMID: 2071514
  • Korean J Physiol Pharmacol.
  • 1997 Aug;1(4):425-434.
Many reports represent that angiotensin II (ANG II) caused a dose dependent biphasic effects on fluid transport in the proximal tubule. However, respective roles of different signaling pathways in mediating these effects remain...
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Inhibition of phospholipase A-2 diminishes the acute alveolar injury induced by interleukin-1-alpha

Lee YM

  • KMID: 2285160
  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):71-78.
In an attempt to investigate the role of phospholipase A-2(PLA-2) in interleukin-1 (IL-1) induced acute lung injury, mepacrine was tried to inhibit PLA-2 in IL-1 induced ARDS rats. For confirmation of acute...
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Effects of mastoparan on a vascular contractility in rabbit aorta

Lee YH, Kang SI, Ahn DS, Lee HY, Choi EJ, Kang BS

Mastoparan is an amphiphilic tetradecapeptide derived from wasp venom which activates G-proteins. Several secondary effects have been attributed to this peptide, including activation of phospholipase and phosphatidylinositol kinase. The aim...
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