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Spontaneous electrical activity in cerebellar Purkinje neurons of postnatal rats

Nam SC

  • KMID: 2071507
  • Korean J Physiol Pharmacol.
  • 1997 Aug;1(4):355-366.
Although cerebellar Purkinje cells display spontaneous electrical activity in vivo and in slice experiments, the mechanism of the spontaneous activity generation has not been clearly understood. The aim of this study was to...
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Abnormal Expression of Neuropeptide Y in the Cerebellar Purkinje Cells of the Ataxic Mutant Mice, Pogo

Lee NS, Kim KH, Kim CT, Ko KO, Kim SH, Park HS, Jeong YG

  • KMID: 2283182
  • Korean J Phys Anthropol.
  • 2004 Jun;17(2):153-161.
The pogo mouse is an autosomal recessive ataxic mutant that arose spontaneously in the inbred KJR/MsKist strain derived originally from Korean wild mice. The ataxic phenotype is characterized by difficulty...
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Immunohistochemical Study of Insulin-Like Growth Factor-I (IGF-I) in the Olivocerebellar System of Developing and Adult Rats

Chang IY, Yoon SP, Chung YY, Kim JJ, Moon JS, Kim YT, Chang YH

  • KMID: 2040095
  • Korean J Anat.
  • 1999 Aug;32(4):509-516.
The developmental topography of olivocerebellar projection is not fully understood. Insulin-like growth factor-I (IGF-I) plays important roles in neural development. This study examined to observe IGF-I-like immunoreactivity (IGF-I IR) in...
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Characterization of Membrane Excitability of Purkinje Cells in Vestibulocerebellum Using Patch Clamp Techniques

Kim CH

Cerebellum is known as a center for sensory/motor coordination and memory storage in motor learning. The vestibular nuclei have extensive afferent and efferent connections with posterior cerebellum which can be...
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Expression of VEGF and its Receptors, Flk-1 and Flt-1 in Postnatal Murine Cerebellum

Kim H, Kim HC

  • KMID: 1982482
  • Korean J Phys Anthropol.
  • 2008 Dec;21(4):279-285.
VEGF and its receptors, flk-1 and flt-1 have been characterized as critical factors in angiogenesis and neurogenesis during development. Here we investigated the expression of VEGF and its receptors in...
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Changes of Calbindin -D28k Expression Levels After Transient Ischemic Damage in Rat Cerebellar Purkinje Cells

Lee YI, Yoo YB

  • KMID: 1982514
  • Korean J Phys Anthropol.
  • 2002 Mar;15(1):61-68.
Cerebellar Purkinje cells are selectively vulnerable to ischemia, although the reasons for this are not known. Moreover, an intracellular Ca 2 +/-overload induced by excitotoxicity (toxic glutamate receptor activation) is...
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Laser Capture Microdissection Reveals Specific Genes Related to Purkinje Cell Death in the Leaner Mice

Nahm SS, Yoo JE, Abbott LC

  • KMID: 2312081
  • Lab Anim Res.
  • 2010 Sep;26(3):301-305.
The leaner mouse carries a mutation in the gene encoding the alpha1A subunit of P/Q-type calcium channels. Leaner mice exhibit extensive cerebellar granule and Purkinje cell loss that results in...
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Degenerative Change of Cerebellar Purkinje Cells by Harmaline Treatment

Kim JH, Jun JY, You HJ, Kee KH, Oh JW, Kim YT, Chang IY

  • KMID: 1517160
  • Korean J Phys Anthropol.
  • 2003 Mar;16(1):39-49.
The indole alkaloid harmaline has been to cause tremor and ataxia, and produce cerebellar neurotoxicity in rat. Degeneration of Purkinje cell alligned in narrow parasagittal bands result from excitation of...
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4-Aminopyridine (4-AP) augments Ca(2+)-dependent action potential and changes oscillatory firing patterns in rat cerebellar Purkinje cells

Seo WS, Shin JH, Suh CK

Intracellular recordings in cerebellar slice preparation showed that applications of 4-AP altered the pattern of oscillatory firing activity in Purkinje cells (PCs), especially yielding pronounced changes in action...
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Effects of Long-Term Alcohol Treatment Combined with Vitamins or Piracetam on the Ultrastructure of Rat Hippocampal and Cerebellar Neurons

Sohn CH, Lee SI, Kwak JS, Jeong IW

  • KMID: 1899251
  • J Korean Soc Biol Psychiatry.
  • 2000 Nov;7(2):164-173.
This study was carried out to investigate the direct neurotoxicity of alcohol on CNS and the effects of piracetam or vitamins on ultrastructural changes of the rat cerebellar and hippocampal...
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Purkinje cells loss in off spring due to maternal morphine sulfate exposure: a morphometric study

Golalipour MJ, Ghafari S

The toxic effects of morphine sulfate in the adult cerebral cortex and one-day neonatal cerebellum have been studied. This study was carried out to evaluate the effect of maternal morphine...
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Differences of Zebrin II Expression Pattern Between Normal Balb/C and Ataxic Pogo Mouse Cerebellum

Lee NS, Kim CT, Kim KH, Kim SK, Chung SH, Ko KO, Sawada K, Fukui Y, Hyun BW, Won MH, Jeong YG

  • KMID: 2224512
  • Korean J Anat.
  • 2003 Dec;36(6):457-462.
The purpose of this study is to identify the differences of zebrin II expression between ataxic pogo and normal Balb/C mouse cerebellum. Zebrin II is expressed by subsets of Purkinje...
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Unsolved Questions on the Anatomy of the Ventricular Conduction System

Oh IY, Cha MJ, Lee TH, Seo JW, Oh S

We reviewed the anatomical characteristics of the conduction system in the ventricles of human and ungulate hearts and then raised some questions to be answered by clinical and anatomical studies...
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Postnatal Developmental Expression of TEM7 mRNA and its Putative Ligand in the Rat Cerebellum

Kang DS, Seo IA, Lee HK, Chung JY, Kim JM, Lee KY, Park HT

  • KMID: 2092865
  • Korean J Anat.
  • 2005 Oct;38(5):469-475.
Tumor endothelial marker 7 (TEM7) is a putative transmembrane protein that is highly expressed in the tumor endothelium and cerebellar neurons. In the present study, the expression profile of TEM7...
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Differential Expression of Neuronal Death-related Factors in Aged Rat Cerebellum

Park BJ, Chung YH, Kim SS, Kim KY, Lee WB

  • KMID: 2376075
  • Korean J Phys Anthropol.
  • 2007 Jun;20(2):145-155.
In the present study, we investigated the expression of apoptosis-associated proteins in the cerebellum of aged rats: IGF-I receptor (IGF-IR), nitrotyrosine (NT), p53, key pro-apoptotic gene ICH-1 (caspase-2), c-Fos and...
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The Emerging Concept of Intrinsic Plasticity: Activity-dependent Modulation of Intrinsic Excitability in Cerebellar Purkinje Cells and Motor Learning

Shim HG, Lee YS, Kim SJ

What is memory? How does the brain process the sensory information and modify an organism's behavior? Many neuroscientists have focused on the activity- and experience-dependent modifications of synaptic functions in...
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Intravenous Anesthetic, Propofol Affects Synaptic Responses in Cerebellar Purkinje Cells

Lee KY, Jang Y, Lee MH, Kim YI, Jung SC, Han SY, Kim SH, Park HS, Kim DK

OBJECTIVE: Propofol is an intravenously administered anesthetic that enhances γ-aminobutyric acid-mediated inhibition in the central nerve system. Other mechanisms may also be involved in general anesthesia. Propofol has been implicated...
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Expression of HSP27 and alphaB-crystallin in Avian Cerebellum during Development

Seo JH, Moon SW, Sohn HJ

  • KMID: 1510219
  • Korean J Anat.
  • 2006 Dec;39(6):453-460.
It is well known that small heat shock proteins play a role as molecular chaperone. However, during normal development of the cerebellum, expression and distribution of HSP27 and alphaB-crystallin (alphaBC)...
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Immunohistochemistry of Voltage-Gated Calcium Channel alpha1B Subunit in Mouse Cerebellum

Chung SH, Lee KY, Kim KH, Kim CT, Lee NS, Sawada K, Haga H, Lee BC, Fukui Y, Rhee MH, Jeong YG

  • KMID: 1095118
  • J Vet Sci.
  • 2002 Sep;3(3):175-178.
Secretion of neurotransmitters is initiated by voltagegated calcium influx through presynaptic, voltage- gated N-type calcium channels. However, little is known about their cellular distribution in the mouse cerebellum. In the...
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Immunohistochemical Study on Platelet-Derived Growth Factor alpha-Receptor (PDGF-alphaR) in the Canine Cerebellum During Postnatal Development

Yoon SP, Moon JS, Kim JJ, Yoon Y, You HJ, Cho HY, Chang IY

  • KMID: 2092778
  • Korean J Anat.
  • 2001 Oct;34(5):495-501.
The biological activities of PDGF include stimulation of mitogenesis, chemotaxis, and differentiation. In nervous system, previous studies have shown that PDGF has an important role in the generation of cells...
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