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Mutational Analysis of PUMA Gene in Non-small Cell Lung Cancers

Yoo NJ, Lee JW, Lee SH, Lee SH

PURPOSE: It has become clear that, together with proliferation, deregulation of apoptosis plays a pivotal role in tumorigenesis, and the somatic mutations of apoptosis-related genes have been reported in human...
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Effects of Triterpenoids from Luvunga scandens on Cytotoxic, Cell Cycle Arrest and Gene Expressions in MCF-7 Cells

Taher M, Al-Zikri P, Susanti D, Ichwan SJ, Rezali MF

Plant-derived triterpenoids commonly possesses biological properties such as anti-inflammatory, anti-microbial, anti-viral and anti-cancer. Luvunga scandens is one of the plant that produced triterpenoids. The aims of the study was to...
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Mutational Analysis of Proapoptotic bcl-2 Family genes in Colon Carcinomas

Soung YH, Lee JW, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH

  • KMID: 1598092
  • Korean J Pathol.
  • 2005 Jun;39(3):168-171.
BACKGROUND: Several lines of evidence have indicated that the deregulation of apoptosis is involved in the mechanisms of cancer development, and somatic mutations of the apoptosisrelated genes have been reported...
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The Effect of FK506 to Generate Reactive Oxygen Species on T Lymphocyte Death

Lee HK, Chung SY, Choi SJ

PURPOSE: Tacrolimus (FK506) has been widely used as an immunosuppressant in organ transplanted recipients to suppress organ rejection phenomenon. We investigated the role of oxidative stress and heme oxygense-1 by...
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Alcohol-related emergency department visits and income inequality in New York City, USA: an ecological study

Reilly KH, Bartley K, Paone D, Tuazon E

OBJECTIVES: Previous research has found that greater income inequality is related to problematic alcohol use across a variety of geographical areas in the USA and New York City (NYC). Those...
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The Blocking of c-Met Signaling Induces Apoptosis through the Increase of p53 Protein in Lung Cancer

Jung HY, Joo HJ, Park JK, Kim YH

  • KMID: 1804885
  • Cancer Res Treat.
  • 2012 Dec;44(4):251-261.
PURPOSE: c-Met is an attractive potential target for novel therapeutic inhibition of human cancer, and c-Met tyrosine kinase inhibitors (TKIs) are effective growth inhibitors of various malignancies. However, their mechanisms...
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