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Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats

Lee B, Yeom M, Shim I, Lee H, Hahm DH

Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but...
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Promising Neuroimaging Biomarkers in Depression

Lai CH

The neuroimaging has been applied in the study of pathophysiology in major depressive disorder (MDD). In this review article, several kinds of methodologies of neuroimaging would be discussed to summarize...
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Distinct Topographical Patterns of Spike-Wave Discharge in Transgenic and Pharmacologically Induced Absence Seizure Models

Lee S, Hwang E, Lee M, Choi JH

Absence seizures (AS) are generalized non-convulsive seizures characterized by a brief loss of consciousness and spike-and-wave discharges (SWD) in an electroencephalogram (EEG). A number of animal models have been developed...
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New Onset Obsessive Compulsive Disorder Following High Frequency Repetitive Transcranial Magnetic Stimulation over Left Dorsolateral Prefrontal Cortex for Treatment of Negative Symptoms in a Patient with Schizophrenia

Garg H, Kumar S, Singh S, Kumar N, Verma R

Obsessive-compulsive symptoms and/or obsessive-compulsive disorders (OCD) are frequently comorbid with schizophrenia, though the exact clinical and etiological relationship between them is poorly understood. Here we describe a case that, to...
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Long-term Effects of Aripiprazole Treatment during Adolescence on Cognitive Function and Dopamine D2 Receptor Expression in Neurodevelopmentally Normal Rats

Choi HJ, Im SJ, Park HR, Park S, Kim CE, Ryu S

OBJECTIVE: This study aimed to investigate the long-term effects of aripiprazole treatment during adolescence on behavior, cognitive function, and dopamine D2 receptor (D2R) expression in adult rats. METHODS: Adolescent male Sprague-Dawley...
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Neuroanatomical Predictors of Dysphagia after Stroke: Voxel-Based Lesion Symptom Mapping Study

Pyun SB, Yoo HJ, Jung Y, Tae WS

OBJECTIVE: Dysphagia is a common consequence of stroke with a negative effect on the clinical outcome. Given these potential outcomes, it is important to identify the precursors to dysphagia after...
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Restoration of Cdk5, TrkB and Soluble N-ethylmaleimide-Sensitive Factor Attachment Protein Receptor Proteins after Chronic Methylphenidate Treatment in Spontaneous Hypertensive Rats, a Model for Attention-Deficit Hyperactivity Disorder

Kim Y, Jeon S, Jeong HJ, Lee SM, Peña ID, Kim HJ, Han DH, Kim BN, Cheong JH

OBJECTIVE: Synaptic vesicle mobilization and neurite outgrowth regulation molecules were examined in modulation of effects of methylphenidate (MPH) in Spontaneous Hypertensive Rats (SHRs), a model for attention-deficit hyperactivity disorder (ADHD). METHODS:...
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Mechanism of Mindfulness-Based Intervention and Neurobiological Basis

Kim HG

Mindfulness is a process in which all thoughts, feelings, sensations, and all phenomena that happen to me are uncritically recognized as they are, so that they are eventually accepted and...
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A Comprasion of the Activation of Mirror Neurons Induced by Action Observation between Simple and Complex Hand Movement

Lee MY, Kim JS

PURPOSE: We compared the activation pattern of the mirror neurons (MN) between two types of hand movement according to action observation using functional MRI. METHODS: Twelve right-handed healthy subjects (5 male...
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Polymorphisms of Ionotropic Glutamate Receptor-Related Genes and the Risk of Autism Spectrum Disorder in a Chinese Population

Xie X, Hou F, Li L, Chen Y, Liu L, Luo X, Gu H, Li X, Zhang J, Gong J, Song R

OBJECTIVE: To evaluate the association of GRIK2 and NLGN1 with autism spectrum disorder in a Chinese population. METHODS: We performed spatio-temporal expression analysis of GRIK2 and NLGN1 in the developing prefrontal...
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Glutamine Supplementation Ameliorates Chronic Stress-induced Reductions in Glutamate and Glutamine Transporters in the Mouse Prefrontal Cortex

Baek JH, Vignesh A, Son H, Lee DH, Roh GS, Kang SS, Cho GJ, Choi WS, Kim HJ

Chronic immobilization stress (CIS) induces low levels of glutamate (Glu) and glutamine (Gln) and hypoactive glutamatergic signaling in the mouse prefrontal cortex (PFC), which is closely related to the Glu-Gln...
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Assessment of Cognitive Phenotyping in Inbred, Genetically Modified Mice, and Transgenic Mouse Models of Alzheimer's Disease

Kim DH, Jang YS, Jeon WK, Han JS

Genetically modified mouse models are being used predominantly to understand brain functions and diseases. Well-designed and controlled behavioral analyses of genetically modified mice have successfully led to the identification of...
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Association Between Duration of Dysphagia Recovery and Lesion Location on Magnetic Resonance Imaging in Patients With Middle Cerebral Artery Infarction

Kim JH, Oh SH, Jeong HJ, Sim YJ, Kim DG, Kim GC

OBJECTIVE: To investigate association between lesion location on magnetic resonance imaging (MRI) performed after an infarction and the duration of dysphagia in middle cerebral artery (MCA) infarction. METHODS: A videofluoroscopic swallowing...
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Effects of Amisulpride Adjunctive Therapy on Working Memory and Brain Metabolism in the Frontal Cortex of Patients with Schizophrenia: A Preliminary Positron Emission Tomography/Computerized Tomography Investigation

Park JH, Hong JS, Kim SM, Min KJ, Chung US, Han DH

OBJECTIVE: Dopamine plays a significant role in working memory by acting as a key neuromodulator between brain networks. Additionally, treatment of patients with schizophrenia using amisulpride, a pure dopamine class...
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Abnormalities in Inflammatory Cytokines Confer Susceptible to Chronic Neuropathic Pain-related Anhedonia in a Rat Model of Spared Nerve Injury

Fang X, Zhan G, Zhang J, Xu H, Zhu B, Hu Y, Yang C, Luo A

OBJECTIVE: Patients with chronic neuropathic pain (CNP) have a higher incidence to develop depression. However, its pathogenesis has not yet been fully elucidated. Here we aimed to investigate the role...
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A Functional Domain Based Approach in Neurocognitive Rehabilitation with Transcranial Direct Current Stimulation: A Case Report

Sreeraj VS, Shivakumar V, Bose A, Abhiram PN, Agarwal SM, Chhabra H, Narayanaswamy JC, Venkatasubramanian G

Transcranial direct current stimulation (tDCS) is a novel brain stimulation technique which has kindled hope in alleviating motor, language as well as cognitive deficits in neuronal injury. Current case report...
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Alteration of Semantic Networks during Swear Words Processing in Schizophrenia

Lee SW, Jeong B, Park JI, Chung GH, Lee HJ, Cui Y, Kim WS, Oh KH, Oh IS, Shen GF, Chung YC

OBJECTIVE: Positive symptoms, such as delusion and hallucination, commonly include negative emotional content in schizophrenia. We investigated the neural basis implicated during the processing of strong negative emotional words in...
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Brain Activation Patterns Associated with the Effects of Fearful Distractors during Working Memory Maintenance in Patients with Schizophrenia

Park JI, Kim GW, Jeong GW, Yang JC

OBJECTIVE: The neural correlates underlying the effects of emotional distraction during working memory (WM) tasks in patients with schizophrenia have yet to be clearly identified. Thus, the present study employed...
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Impact of Repetitive Transcranial Magnetic Stimulation with Computerized Cognitive Enhancement Training on Change in Cognitive Function of Mild Cognitive Impairment Patients : Existing, Sham Treatment Controlled, Pilot Study

Lee SE, Moon HS, Chung ST, Lee CU, Kang DW

OBJECTIVE: This study aimed to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) and computerized cognitive enhancement training combined treatment on cognitive function in mild cognitive impairment (MCI) patients,...
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Neural Mechanism of Second Language Processing in Korean-English Bilingual Children

Lee YY, Baek BH, Kim SK, Park IW, Jeong GW, Baek S, Yoon W

PURPOSE: To evaluate the neural mechanism of second language processing in Korean-English bilingual children using functional MRI (fMRI). MATERIALS AND METHODS: The study was conducted on 20 Korean elementary school children...
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