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Establishment of patient-derived three-dimensional organoid culture in renal cell carcinoma

Na JC, Kim JH, Kim SY, Gu YR, Jun DY, Lee HH, Yoon YE, Choi KH, Hong SJ, Han WK

PURPOSE: Renal cell carcinoma is a heterogeneous kidney cancer, and over 403,000 cases were reported worldwide in 2018. Current methods for studying renal cell carcinoma are limited to two-dimensional (2D)...
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Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis

Liu Z, Chen J, Cheng L, Li H, Liu S, Lou H, Shi J, Sun Y, Wang D, Wang C, Wang X, Wei Y, Wen W, Yang P, Yang Q, Zhang G, Zhang Y, Zhao C, Zhu D, Zhu L, Chen F, Dong Y, Fu Q, Li J, Li Y, Liu C, Liu F, Lu M, Meng Y, Sha J, She W, Shi L, Wang K, Xue J, Yang L, Yin M, Zhang L, Zheng M, Zhou B, Zhang L

The current document is based on a consensus reached by a panel of experts from the Chinese Society of Allergy and the Chinese Society of Otorhinolaryngology-Head and Neck Surgery, Rhinology...
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Therapeutic Drug Monitoring of Biologic Agents in the Era of Precision Medicine

Lee SY

No abstract available.
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Views on Precision Medicine among Health Professionals in Korea: A Mixed Methods Study

Cho HN, Shin SY, Hwangbo B, Chang YJ, Cho J, Kong SY, Choi KS, Lee ES

This study aimed to investigate awareness, attitudes, and perspectives on precision medicine among health professionals in Korea and to identify issues that need to be addressed before implementing precision medicine....
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Precision Medicine and Cardiovascular Health: Insights from Mendelian Randomization Analyses

Spiller W, Jung KJ, Lee JY, Jee SH

Cardiovascular disease (CVD) is considered a primary driver of global mortality and is estimated to be responsible for approximately 17.9 million deaths annually. Consequently, a substantial body of research related...
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Phenotypes and endotypes of atopic dermatitis: Clinical implications

Kim M, Kim J

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, characterized by a complex pathophysiology and a variety of clinical phenotypes. However, heterogeneous clinical phenotypes are generally not considered...
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Comprehensive Molecular Characterization of Urological Malignancies: Literature Review of Landmark Studies

Suh J, Jeong CW

Owing to recent advancements in next-generation sequencing and bioinformatics, genetic data of urological malignancies exponentially studied and published. Application of precision medicine strategies for cancer diagnosis, management is just around...
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Radioimmunotherapy (RIT) in Brain Tumors

Gholamrezanezhad A, Shooli H, Jokar N, Nemati R, Assadi M

Annually, the incidence of brain tumors has slightly increased and also the patient prognosis is still disappointing, especially for high-grade neoplasms. So, researchers seek methods to improve therapeutic index as...
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Artificial Intelligence for Adult Spinal Deformity

Joshi RS, Haddad AF, Lau D, Ames CP

Adult spinal deformity (ASD) is a complex disease that significantly affects the lives of many patients. Surgical correction has proven to be effective in achieving improvement of spinopelvic parameters as...
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Deep Learning in Medical Imaging

Kim M, Yun J, Cho Y, Shin K, Jang R, Bae HJ, Kim N

The artificial neural network (ANN), one of the machine learning (ML) algorithms, inspired by the human brain system, was developed by connecting layers with artificial neurons. However, due to the...
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Present and Future of Endoscopic Ultrasound-Guided Tissue Acquisition in Solid Pancreatic Tumors

Park JK, Lee KH

Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is a well-established method for pathological diagnosis of solid pancreatic neoplasm. It can be performed either as EUS-guided fine-needle aspiration (EUS-FNA) or EUS-guided fine-needle biopsy...
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Comparing the Effectiveness of Olfactory Training, According as Type and Preference of Odorant

Kim DY, Ha JH, Lee JH, Kim HJ, Park DY

BACKGROUND AND OBJECTIVES: Recently, the prevalence of olfactory dysfunction has increased with pollution and population adequate. Treatment by olfactory training has been suggested as an alternative method, but there is...
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Molecular Imaging in Breast Cancer

Miladinova D

Breast cancer (BC) is themost common cancer among females withmore than 2 million new cases diagnosed worldwide in 2018. Although the prognosis in the majority of cases in the early...
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Current Development and Research Trend of Chemotherapeutic Agents for Head and Neck Squamous Cell Carcinoma

Lee YS

After FDA approval of cetuximab at 2006, receptor tyrosine kinase, including an epidermal growth factor receptor, blocking agents have been evaluated for head and neck squamous cell carcinoma (HNSCC). Agents...
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Introduction of Vaccinomics to Develop Personalized Vaccines in Light of Changes in the Usage of Hantaan Virus Vaccine (Hantavax®) in Korea

Bae JM

The Ministry of Food and Drug Safety of Korea made an official announcement in March 2018 that the total number of inoculations of Hantaan virus vaccine (Hantavax®) would change from...
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Pharmacogenetics and Depression: A Critical Perspective

Corponi F, Fabbri C, Serretti A

Depression leads the higher personal and socio-economical burden within psychiatric disorders. Despite the fact that over 40 antidepressants (ADs) are available, suboptimal response still poses a major challenge and is...
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Clinical Implementation of Precision Medicine in Gastric Cancer

Jeon J, Cheong JH

Gastric cancer (GC) is one of the deadliest malignancies in the world. Currently, clinical treatment decisions are mostly made based on the extent of the tumor and its anatomy, such...
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Human Induced Pluripotent Stem Cells: Clinical Significance and Applications in Neurologic Diseases

Chang EA, Jin SW, Nam MH, Kim SD

The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of...
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Current status and future direction of digital health in Korea

Shin SY

Recently, digital health has gained the attention of physicians, patients, and healthcare industries. Digital health, a broad umbrella term, can be defined as an emerging health area that uses brand...
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The role of evidence-based algorithms for rotational thromboelastometry-guided bleeding management

Görlinger K, Pérez-Ferrer A, Dirkmann D, Saner F, Maegele M, Calatayud , Kim TY

Rotational thromboelastometry (ROTEM) is a point-of-care viscoelastic method and enables to assess viscoelastic profiles of whole blood in various clinical settings. ROTEM-guided bleeding management has become an essential part of...
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