- Neuroprotective potential of imatinib in global ischemia-reperfusion-induced cerebral injury: possible role of Janus-activated kinase 2/signal transducer and activator of transcription 3 and connexin 43
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Wang J, Bai T, Wang N, Li H, Guo X
- KMID: 2466565
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):11-18.
- doi: 10.4196/kjpp.2020.24.1.11
The present study was aimed to explore the neuroprotective role of imatinib in global ischemia-reperfusion-induced cerebral injury along with possible mechanisms. Global ischemia was induced in mice by bilateral carotid... -
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- A PAS-Containing Histidine Kinase is Required for Conidiation, Appressorium Formation, and Disease Development in the Rice Blast Fungus, Magnaporthe oryzae
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Shin JH, Gumilang A, Kim MJ, Han JH, Kim KS
- KMID: 2470180
- Mycobiology.
- 2019 Dec;47(4):473-482.
- doi: 10.1080/12298093.2019.1689037
Rice blast disease, caused by the ascomycete fungus Magnaporthe oryzae, is one of the most important diseases in rice production. PAS (period circadian protein, aryl hydrocarbon receptor nuclear translocator protein,... -
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- Anticancer Activity of Tubulosine through Suppression of Interleukin-6-Induced Janus Kinase 2/Signal Transducer and Activation of Transcription 3 Signaling
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Kim BH, Yi EH, Li YC, Park IC, Park JY, Ye SK
- KMID: 2458858
- J Breast Cancer.
- 2019 Sep;22(3):362-374.
- doi: 10.4048/jbc.2019.22.e34
PURPOSE: The chemical structure of tubulosine has been known since the mid-1960s. However, little is known about its biological and pharmacological functions. The aim of this study was to investigate... -
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- Suppression of CD81 promotes bladder cancer cell invasion through increased matrix metalloproteinase expression via extracellular signal-regulated kinase phosphorylation
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Park HS, Lee S, Lee J, Shin HB, Yoo SM, Lee MS, Park J
- KMID: 2455968
- Investig Clin Urol.
- 2019 Sep;60(5):396-404.
- doi: 10.4111/icu.2019.60.5.396
PURPOSE: CD81 is a prognostic biomarker for high-grade bladder cancer (BC). In this study, we aimed to determine the functional mechanisms underlying the role of CD81 in BC progression. MATERIALS AND... -
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- Antitumor profiles and cardiac electrophysiological effects of aurora kinase inhibitor ZM447439
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Lee HA, Kwon M, Kim HA, Kim KS
- KMID: 2455815
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):393-402.
- doi: 10.4196/kjpp.2019.23.5.393
Aurora kinases inhibitors, including ZM447439 (ZM), which suppress cell division, have attracted a great deal of attention as potential novel anti-cancer drugs. Several recent studies have confirmed the anti-cancer effects... -
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- Inhibition of MicroRNA-15a/16 Expression Alleviates Neuropathic Pain Development through Upregulation of G Protein-Coupled Receptor Kinase 2
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Li T, Wan Y, Sun L, Tao S, Chen P, Liu C, Wang K, Zhou C, Zhao G
- KMID: 2455097
- Biomol Ther.
- 2019 Jul;27(4):414-422.
- doi: 10.4062/biomolther.2018.073
There is accumulating evidence that microRNAs are emerging as pivotal regulators in the development and progression of neuropathic pain. MicroRNA-15a/16 (miR-15a/16) have been reported to play an important role in... -
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- Enhanced polo-like kinase 1 expression in myelodysplastic syndromes
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Min KI, Park S, Shin SH, Kwon YR, Kim HJ, Kim YJ
- KMID: 2451009
- Blood Res.
- 2019 Jun;54(2):102-107.
- doi: 10.5045/br.2019.54.2.102
BACKGROUND: Cancer is characterized by uncontrolled cellular proliferation, and Polo-like kinase 1 (PLK1), a key regulator of the cell cycle, is overexpressed in many cancers, including acute leukemia and lymphoma.... -
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- An Anti-Cancer Drug Candidate CYC116 Suppresses Type I Hypersensitive Immune Responses through the Inhibition of Fyn Kinase in Mast Cells
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Park YH, Kim HW, Kim HS, Nam ST, Lee D, Lee MB, Min KY, Koo J, Kim SJ, Kim YM, Kim HS, Choi WS
- KMID: 2447858
- Biomol Ther.
- 2019 May;27(3):311-317.
- doi: 10.4062/biomolther.2018.148
Mast cells are the most prominent effector cells of Type 1 hypersensitivity immune responses. CYC116 [4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin-4-yl)phenyl] pyrimidin-2-amine] is under development to be used as an anti-cancer drug, but the inhibitory... -
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- Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells
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Lee M, Lee KH, Min A, Kim J, Kim S, Jang H, Lim JM, Kim SH, Ha DH, Jeong WJ, Suh KJ, Yang YW, Kim TY, Oh DY, Bang YJ, Im SA
- KMID: 2464392
- Cancer Res Treat.
- 2019 Apr;51(2):451-463.
- doi: 10.4143/crt.2017.341
PURPOSE: Pim kinases are highly conserved serine/threonine kinases, and different expression patterns of each isoform (Pim-1, Pim-2, and Pim-3) have been observed in various types of human cancers, including gastric... -
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- Rab GTPases as Physiological Substrates of LRRK2 Kinase
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Seol W, Nam D, Son I
- KMID: 2450209
- Exp Neurobiol.
- 2019 Apr;28(2):134-145.
- doi: 10.5607/en.2019.28.2.134
LRRK2 (Leucine-Rich Repeat Kinase 2) is a gene whose specific mutations cause Parkinson's disease (PD), the most common neurodegenerative movement disorder. LRRK2 harbors GTPase and kinase activities, two enzyme activities... -
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- Discovery of an Indirubin Derivative as a Novel c-Met Kinase Inhibitor with In Vitro Anti-Tumor Effects
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Ndolo KM, An SJ, Park KR, Lee HJ, Yoon KB, Kim YC, Han SY
- KMID: 2442014
- Biomol Ther.
- 2019 Feb;27(2):216-221.
- doi: 10.4062/biomolther.2018.091
The c-Met protein is a receptor tyrosine kinase involved in cell growth, proliferation, survival, and angiogenesis of several human tumors. Overexpression of c-Met has been found in gastric cancers and... -
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- Expression of polo-like kinase 1 in pre-implantation stage murine somatic cell nuclear transfer embryos
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Moon J, Roh S
- KMID: 2434771
- J Vet Sci.
- 2019 Jan;20(1):2-9.
- doi: 10.4142/jvs.2019.20.1.2
Somatic cell nuclear transfer (SCNT) has various applications in research, as well as in the medical field and animal husbandry. However, the efficiency of SCNT is low and the accurate... -
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- Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing
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Park BM, Roh JI, Lee J, Lee HW
- KMID: 2459304
- Lab Anim Res.
- 2018 Dec;34(4):264-269.
- doi: 10.5625/lar.2018.34.4.264
Cell cycle dysfunction can cause severe diseases, including neurodegenerative disease and cancer. Mutations in cyclin-dependent kinase inhibitors controlling the G1 phase of the cell cycle are prevalent in various cancers.... -
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- The Open Issues Regarding Cyclin-Dependent Kinase 4/6 Inhibitors in the Management of Advanced Breast Cancer
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Rossi L
- KMID: 2429827
- J Breast Cancer.
- 2018 Dec;21(4):468-470.
- doi: 10.4048/jbc.2018.21.e59
No abstract available. -
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- LAMMER Kinase Lkh1 Is an Upstream Regulator of Prk1-Mediated Non-Sexual Flocculation in Fission Yeast
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Park YD, Kwon SJ, Bae KS, Park HM
- KMID: 2427104
- Mycobiology.
- 2018 Sep;46(3):236-241.
- doi: 10.1080/12298093.2018.1513115
The cation-dependent galactose-specific flocculation activity of the Schizosaccharomyces pombe null mutant of lkh1âº, the gene encoding LAMMER kinase homolog, has previously been reported by our group. Here, we show that... -
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- PIM Kinase as an Executional Target in Cancer
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Zhang X, Song M, Kundu JK, Lee MH, Liu ZZ
- KMID: 2425313
- J Cancer Prev.
- 2018 Sep;23(3):109-116.
- doi: 10.15430/JCP.2018.23.3.109
PIM (proviral integration site for moloney murine leukemia virus) kinase plays a key role as an oncogene in various cancers including myeloma, leukemia, prostate and breast cancers. The aberrant expression... -
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- LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation
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Ho DH, Je AR, Lee H, Son I, Kweon HS, Kim HG, Seol W
- KMID: 2416244
- Exp Neurobiol.
- 2018 Jun;27(3):171-180.
- doi: 10.5607/en.2018.27.3.171
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). LRRK2 contains a functional kinase domain and G2019S, the most prevalent LRRK2 pathogenic mutation,... -
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- Overexpression of miR-155-5p Inhibits the Proliferation and Migration of IL-13-Induced Human Bronchial Smooth Muscle Cells by Suppressing TGF-β-Activated Kinase 1/MAP3K7-Binding Protein 2
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Shi Y, Fu X, Cao Q, Mao Z, Chen Y, Sun Y, Liu Z, Zhang Q
- KMID: 2409061
- Allergy Asthma Immunol Res.
- 2018 May;10(3):260-267.
- doi: 10.4168/aair.2018.10.3.260
PURPOSE: Molecular mechanisms leading to asthma is still ill-defined. Though the function of microRNAs (miRNAs) in asthma was previously reported, the involvement of miR-155 in important features of this disease... -
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- Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways
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Joo HJ, Jeong KH, Kim JE, Kang H
- KMID: 2395183
- Ann Dermatol.
- 2017 Dec;29(6):747-754.
- doi: 10.5021/ad.2017.29.6.747
BACKGROUND: The human dermal papilla cells (hDPCs) play an important role in regulation of hair cycling and growth. OBJECTIVE: The aim of this study was to investigate the effect of different... -
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- 20(S)-Protopanaxadiol enhances angiogenesis via HIF-1α-mediated VEGF secretion by activating p70S6 kinase and benefits wound healing in genetically diabetic mice
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Zhang EY, Gao B, Shi HL, Huang LF, Yang L, Wu XJ, Wang ZT
- KMID: 2395749
- Exp Mol Med.
- 2017 Oct;49(10):e387.
- doi: 10.1038/emm.2017.151
Impaired angiogenesis is one of the crucial factors that impede the wound healing process in diabetic foot ulcers (DFUs). In this study, we found that 20(S)-protopanaxadiol (PPD), an aglycone of... -
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