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Effect of Sildenafil on Neuropathic Pain and Hemodynamics in Rats

Huang LJ, Yoon MH, Choi JI, Kim WM, Lee HG, Kim YO

PURPOSE: The inhibition of phosphodiesterase 5 produces an antinociception through the increase of cyclic guanosine monophosphate (cGMP), and increasing cGMP levels enhance the release of gamma-aminobutyric acid (GABA). Furthermore, this...
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Use of Tadalafil for Treating Pulmonary Arterial Hypertension Secondary to Chronic Obstructive Pulmonary Disease

Kim HS, Park JH, Park SJ, Park JK, Lee HB

Pulmonary arterial hypertension (PAH) secondary to chronic obstructive pulmonary disease (COPD) is incurable and it has an unpredictable survival rate. Two men who suffered from COPD presented with progressive dyspnea...
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