- beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells
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Yi YW, Kang HJ, Bae EJ, Oh S, Seong YS, Bae I
- KMID: 2155408
- Exp Mol Med.
- 2015 Feb;47(2):e143.
- doi: 10.1038/emm.2014.127
An F-box protein, beta-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene.... -
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- Dual-Blocking of PI3K and mTOR Improves Chemotherapeutic Effects on SW620 Human Colorectal Cancer Stem Cells by Inducing Differentiation
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Kim MJ, Koo JE, Han GY, Kim B, Lee YS, Ahn C, Kim CW
- KMID: 2363495
- J Korean Med Sci.
- 2016 Mar;31(3):360-370.
- doi: 10.3346/jkms.2016.31.3.360
Cancer stem cells (CSCs) have tumor initiation, self-renewal, metastasis and chemo-resistance properties in various tumors including colorectal cancer. Targeting of CSCs may be essential to prevent relapse of tumors after... -
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- The reno-protective effect of a phosphoinositide 3-kinase inhibitor wortmannin on streptozotocin-induced proteinuric renal disease rats
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Kim SH, Jang YW, Hwang P, Kim HJ, Han GY, Kim CW
- KMID: 1120141
- Exp Mol Med.
- 2012 Jan;44(1):45-51.
- doi: 10.3858/emm.2012.44.1.004
Diabetic nephropathy (DN) is a progressive kidney disease that is caused by injury to kidney glomeruli. Podocytes are glomerular epithelial cells and play critical roles in the glomerular filtration barrier.... -
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