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Protection Against Electroshock- and Pentylenetetrazol-induced Seizures by the Water Extract of Rehmannia glutinous can be Mediated through GABA Receptor-chloride Channel Complexes

Kim M, Kim HJ, Kim SM, De la Peña JB, Dela Peña IJ, Botanas CJ, Woo T, Lee YS, Ryu JH, Cheong JH

Epilepsy is a brain disorder that affects millions of people worldwide. It is characterized by recurrent and unpredictable seizures that are usually controlled with antiepileptic/anticonvulsive drugs. However, most antiepileptic drugs...
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Lamotrigine Decreased Hippocampal Damage and Improved Vascular Risk Markers in a Rat Model of Pentylenetetrazole Induced Kindling Seizure

Haggag BS, Hasanin AH, Raafat MH, Abdel Kawy HS

Various antiepileptic drugs (AEDs) especially enzyme-inducing AEDs might be associated with increased vascular risk, through impairment of the endogenous antioxidative ability which may trigger oxygen-dependent tissue injury. Lamotrigine (LTG) a...
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Tamoxifen Mimics the Effects of Endogenous Ovarian Hormones on Repeated Seizures Induced by Pentylenetetrazole in Rats

Mansouri S, Ataei ML, Hosseini M, Bideskan A

In the present study, the effects of tamoxifen on pentylenetetrazole (PTZ)-induced repeated seizures and hippocampal neuronal damage in ovariectomized rats were investigated. Thirty seven virgin female Wistar rats were divided...
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Neuropharmacological effects of deltamethrin in rats

Manna S, Bhattacharyya D, Mandal TK, Dey S

This study examined the effect of deltamethrin on some of the neuropharmacological paradigms in a rat brain such as the motor co-ordination test using a rotarod, the pentobarbitone-induced sleeping time and pentylenetetrazole (PTZ)-induced convulsion...
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In Vitro Effect of Carbamazepine, D-(-)-2-Amino-5-Phosphonopentanoic Acid and 6-Cyano-7-Nitroquinoxaline-Dione on Pentylenetetrazole-Induced Epileptiform Activity in Young Rat Visual Cortex

Choi BJ

  • KMID: 1851944
  • J Korean Epilepsy Soc.
  • 2005 Dec;9(2):137-142.
PURPOSE: Carbamazepine (CBZ) has little untoward effect in behavior, cognition and psychosocial aspects and commonly used in children. But, CBZ can sometimes worsen tonic-clonic seizures. The goal of the present...
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The Protective Effect of Chlorpromazine on Pentylenetetrazole Induced Seizure

Kim EA, Kim DW, Chae SA

  • KMID: 2329287
  • J Korean Child Neurol Soc.
  • 2003 May;11(1):20-23.
PURPOSE: Chlorpromazine(CPZ) is known to inhibit glutamate dehydrogenase(GDH). Reductive amination of alpha-ketoglutarate is catalyzed by GDH and forms glutamate, a major excitatory neurotransmitter. Thus, we hypothesized that CPZ might have...
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A Study on the Age-Dependent Antiepileptic Effects of the Ketogenic Diet in the Pentylenetetrazole-Seizure Animal Model

Kim DW, Chae SA, Park HJ

  • KMID: 2007340
  • J Korean Child Neurol Soc.
  • 2002 May;10(1):29-34.
PURPOSE: The ketogenic diet(KD) has been felt to be clinically more efficacious at younger ages, presumably because of the enhanced ability of the immature brain to extract and utilize ketone...
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Expression Changes of c-Fos Protein of Rat Brain Following Pentylenetetrazol-induced Seizures

Kim EJ, Yoo KS, Hwang GK

  • KMID: 2137161
  • J Korean Child Neurol Soc.
  • 2001 May;9(1):49-58.
PURPOSE: The expression of c-Fos protein has been shown to be a useful marker for elevated levels of neuronal activity generated in the brain following different stimuli, including seizures. This...
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Effects of the Ketogenic Diet on Pentylenetetrazole-Induced Seizure

Kim DW, Kim HS, Ko TS, Chae SA, Kim KJ, Hwang YS

  • KMID: 2137159
  • J Korean Child Neurol Soc.
  • 2001 May;9(1):37-43.
PURPOSE: Despite decades of clinical experience with the ketogenic diet(KD), its efficacy and mechanisms of action have been examined in few animal studies. The present study was designed to investigate...
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The Immunohistochemical Expression of Neuronal Nitric Oxide Synthase in Rat Hippocampus after Pentylenetetrazole-Induced Seizures

Kim DK, Jang TJ

  • KMID: 2335547
  • J Korean Pediatr Soc.
  • 2001 Dec;44(12):1432-1440.
PURPOSE: In order to determine the effect of neuronal nitric oxide synthase(nNOS) in seizure-related neuronal vulnerability of the hippocampus, the expression patterns of nNOS were examined in pentylenetetrazole(PTZ)-induced seizure groups...
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Effect of Gabapentin on Incisional Pain in Rat Pretreated with Pentylenetetrazole

Kim HK, Shin SH, Kwon JY, Shin SU, Kim KH, Chung KS

BACKGROUND: Tissue injury by surgical manipulation or trauma may cause pain hypersensitivity secondary to central sensitization. The aim of this study was to evaluate the postoperative effect of gabapentin...
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The Role of the Glutamate Receptor in the Transient Focal Cerebral Ischemia in Rats

Chae CH, Kim HK, Kim KH, Baik SW, Kim IS

BACKGROUND: To investigate the role of glutamate in the transient focal cerebral ischemia, a reversible middle cerebral artery occlusion model was induced in 25 male Sprague-Dawley rats. METHODS: Triphenyltetrazolium chloride (TTC)...
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The Role of Nitric Oxide in Seizures Induced by Pentylenetetrazole

Kim JH, Kim KK

  • KMID: 1967594
  • J Korean Pediatr Soc.
  • 2000 Oct;43(10):1356-1363.
PURPOSE: Nitric oxide(NO) is a highly reactive messenger molecule that is synthesized by nitric oxide synthase(NOS) in a number of tissues including the brain. Our aim was to examine the possible role...
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Changes of Prostaglandin E-2 Levels in Cerebrospinal Fluid in Children with Febrile Convulsion

Choi BJ, Whang KT

  • KMID: 2177121
  • J Korean Child Neurol Soc.
  • 1998 May;5(2):235-241.
PURPOSE: Prostaglandins(PGs) are known to produce a remarkably broad spectrum of effects that embraces practically every biological function, and has a particular physiological role in the central nervous system. Significant...
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Effect of Prostaglandin Synthetase Inhibitor Pretreatment on Pentylenetetrazol-induced Seizures

Choi BJ, Kim YI, Whang KT

  • KMID: 1961845
  • J Korean Child Neurol Soc.
  • 1998 Oct;6(1):47-54.
PURPOSE: Nonsteroidal anti-inflammatory drugs inhibit the synthesis of prostaglandin(PG) through inhibition of the enzyme, cyclooxygenase. Some of the arachidonic acid metabolites may influence the spread of electrocortical activity, and delay...
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Expression of c-fos mRNA in the Hippocampus of Pentylenetetrazol Kindling Rat

Kim KS, Yoo KM, Suh SI, Yi SD

  • KMID: 2066047
  • J Korean Neurol Assoc.
  • 1996 Mar;14(1):89-101.
Kindling, induced by repeated subconvulsive electrical or chemical stimulations, leads to progressive and permanent amplification of seizure activity, resulting in permanent brain changes. It is a good animal model of...
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Expression of c-myc mRNA in the Hippocampus of Pentylenetetrazol Kindling Rat

Lee JC, Son EI, Kim IH, Lee SD

  • KMID: 2018959
  • J Korean Neurosurg Soc.
  • 1996 Nov;25(11):2173-2181.
Kindling development is a good animal model of epilepsy and neural plasticity. It is induced by repeated subconvulsive electrical or chemical stimulations. This leads to progressive and permanent amplification of...
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Mossy Fiber Synaptic Reorganization of Dentate Gyrus by Pentylenetetrazol Kindling Rats

Yi SD, Lee TH, Park YC

  • KMID: 2342473
  • J Korean Neurol Assoc.
  • 1995 Jun;13(2):239-248.
Recent studies have revealed that mossy fiber(MF) axons of dentate granule cells undergo synaptic reorganization in both electrical kindling models of temporal lobe epilepsy (TLE) and human TLE. This synaptic...
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Development and Persistence of Kindling Phenomenon after Injections of Pentylenetetrazol in Rats

Lee SH, Yi SD, Park YC

  • KMID: 2342430
  • J Korean Neurol Assoc.
  • 1994 Sep;12(3):375-381.
The development of pentylenetetrazol (PTZ) kindling has been controversial, authors confirmed the development of kindling phenomenon in experimental rats following every second or third day intraperitoneal administration of PTZ(20-25mg/kg) to...
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A Study of the Mechanism on Hibernation

Oh YK, Kang HS

The present study was performed in order to test the effects of diphenylhydantoin (DPH) and two central nervous system (CNS) stimulants, intermittent light stimulation(ILS) and pentylenetetrazol (Metrazol) on body temperature...
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