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Effect of pralidoxime on coronary perfusion pressure during cardiopulmonary resuscitation in a pig model

Jung YH, Ryu DH, Jeung KW, Na JY, Lee DH, Lee BK, Heo T, Min YI

OBJECTIVE: Pralidoxime is widely used for the treatment of organophosphate poisoning. Multiple studies have reported its vasoconstrictive property, which may facilitate the restoration of spontaneous circulation (ROSC) after cardiac arrest...
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Unanticipated Difficult Intubation in Patient with Undiagnosed Posterior Glottic Stenosis

Lee S, Lee M, Koo BS, Chung YH

Posterior glottic stenosis (PGS) is frequently caused by prolonged intubation complications, which may limit the movement of the vocal cords and obstruct airway obstruction. Despite of a life-threatening condition, it...
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Relative Risk and Clinical Severity Assessment in Patients with Non-Oral Route Organophosphate Poisoning Compared with Oral Route Poisoning

Jung WJ, Yu MH, Lee Y, Kim H, Cha YS, Park KH

PURPOSE: Organophosphates, commonly used in agricultural pesticides, pose high risks and incidences of poisoning. In the present study, we investigated the relative risk and clinical severity, including laboratory results, of...
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Sudden death caused by trichlorfon poisoning in Korean native cattle

Kim JH, Lee K, Jung JY, Yi H, Sohn JH, So B, Choi EJ

Two 12-month-old cattle with anthelmintics containing trichlorfon the day before death presented to the Animal and Plant Quarantine Agency for diagnosis. In necropsy, they revealed enlargement of the spleens, redness...
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A Case of a Child with Seizure caused by Organophosphate Poisoning

Jang JH, Lee Y, Lee JH, Oh JH, Kim JH, Yoo IH

Seizure is a temporary symptom or sign which is caused by an abnormal electrical stimulation of brain. Depending on whether a seizure has preceding factors or not, it can be...
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Usefulness of serum lactate as a predictor of successful discontinuation of continuous atropine infusion in patients with severe acute organophosphate poisoning

Kwon HC, Cha YS, An GJ, Lee Y, Kim H

OBJECTIVE: In severe organophosphate (OP) poisoning, administration of atropine via continuous intravenous infusion is typically considered. To date, there have been no studies on predicting successful atropine discontinuation through plasma...
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Intermediate syndrome after dermal exposure to organophosphate insecticide

Lee SB, Ryu SH, Park DY, Park JH, Kim JY

Intermediate syndrome (IMS) typically occurs at 24–96 hours following organophosphate (OP) poisoning, after an acute cholinergic crisis, but before OP-induced delayed polyneuropathy. It is characterized by proximal muscle weakness and...
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Methidathion Poisoning

Kim KH, Kim SH, Her C

Although methidathion is an organophosphate insecticide, it is different from the other organophosphates in terms of toxicity. Because of its relatively high fat solubility, the apparent volume of methidathion distribution...
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Pneumatosis Cystoides Intestinales and Portomesenteric Venous Gas following Anticholinesterase Pesticide Poisoning

Lee SH, Lee KW, Jung JH

Pneumatosis cystoides intestinalis and portomesenteric venous gas are uncommon radiological findings, but are found commonly in cases of bowel ischemia, or as a result of various non-ischemic conditions. A 72-year-old...
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Implementing Best Practice in Critically Ill Organophosphate Poisoned Patient Through Simulation-Based Learning Program

Lee JH, Chung SP, Chung HS

PURPOSE: Despite the clinical and socio-economic impact of acute poisoned patients, many of the treatments are not standardized in Korea. Moreover, no formal training that is specifically focused on clinical...
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Blood Lipid Profile as a Prognostic Factor in Patients with Organophosphate Poisoning

Han DG, Kim DH, Park YJ

PURPOSE: The purpose of this study is to compare clinical outcomes with blood lipids level and lipid solubility of organophosphate-poisoned patients. METHODS: Data from 88 patients who visited the emergency room...
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Evaluation of Cardiac Function by Transthoracic Echocardiography in Patients with Myocardial Injury Secondary to Organophosphate Poisoning

Lee Y, Kim OH, Kim HI, Cha KC, Kim H, Lee KH, Hwang SO, Cha YS

  • KMID: 2133230
  • J Korean Soc Clin Toxicol.
  • 2015 Dec;13(2):62-70.
PURPOSE: Cardiac complications may occur in cases of organophosphate (OP) poisoning. However, a few studies regarding patterns of cardiac toxicity as determined by transthoracic echocardiography (TTE) after exposure to OP...
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Effect of Alcohol on Death Rate in Organophosphate Poisoned Patients

Min YH, Park SM, Lee KJ, Oh YT, Ahn HC, Sohn YD, Ahn JY, Lee YH, Ha SO, Kim YJ

  • KMID: 1846319
  • J Korean Soc Clin Toxicol.
  • 2015 Jun;13(1):19-24.
PURPOSE: Many patients who are acutely poisoned with organophosphorus pesticides have co-ingested alcohol. The purpose of this study was to identify the factors that influence mortality in organophosphate intoxication and...
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Acute Pancreatitis after Carbamate Poisoning

Park J, Kim YW, Oh SH, Cha YS, Cha KC, Kim OH, Lee KH, Hwang SO, Kim H

  • KMID: 2203548
  • J Korean Soc Clin Toxicol.
  • 2014 Dec;12(2):77-84.
PURPOSE: Carbamate insecticides are potent cholinesterase inhibitors capable of causing severe cholinergic toxicity. Use of carbamate rather than organophosphate insecticides has been increasing. Compared with organophosphate poisoning, relatively few studies...
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The Features and Prognoses in Organophosphate Intoxication according to Age

Lim SW, Park SM, Lee YH, Lee WW, Ahn JY, Sohn YD, Ahn HC, Kim H

BACKGROUND: The purpose of this study was to identify the factors that influence mortality in organophosphate intoxication and the differences between the elderly (> or =65 years) and younger adults...
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Performance Assessment of the SOFA, APACHE II Scoring System, and SAPS II in Intensive Care Unit Organophosphate Poisoned Patients

Kim YH, Yeo JH, Kang MJ, Lee JH, Cho KW, Hwang S, Hong CK, Lee YH, Kim YW

This study assessed the ability of the Sequential Organ Failure Assessment (SOFA) and Acute Physiology, Chronic Health Evaluation (APACHE) II scoring systems, as well as the Simplified Acute Physiology Score...
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Initial Laboratory Parameters and its Correlation to Intermediate Syndrome in Patients with Acute Organophosphate Poisoning

Lee WK, Chun BJ, Moon JM, Lee SM, Jung YH, Lee BK, Ryu HH, Jeung KW, Heo T, Min YI

  • KMID: 2191966
  • J Korean Soc Emerg Med.
  • 2013 Oct;24(5):557-565.
PURPOSE: The association of serial serum cholinesterase (SChE) activity and the occurrence of intermediate syndrome (IMS) in patients orally poisoned with organophosphate (OP) were investigated. In addition, other clinical and...
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A Case of Central Nervous System (CNS) Toxicity in Acute Organophosphate Intoxication

Lee JS, Paik JH, Yun SH, Kim JH, Han SB, Kim JS, Jung HM

  • KMID: 1482716
  • J Korean Soc Clin Toxicol.
  • 2013 Jun;11(1):31-35.
Acute organophosphate intoxication is important because of its high morbidity and mortality. The mortality is still high despite the use of atropine as specific antidotal therapy and oximes for reactivation...
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A Case of Amitraz Poisoning Initially Misdiagnosed as Acute Organophosphate Insecticide Poisoning

Cho Y, Kim JW

  • KMID: 2317669
  • Soonchunhyang Med Sci.
  • 2012 Dec;18(2):151-154.
Amitraz is acaricidal and insecticidal pesticide used worldwide to control ticks and mites in plants and animals. Amitraz poisoning is characterized by clinical toxidrome such as central nervous system, respiratory...
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Occupational Neurotoxic Diseases in Taiwan

Liu CH, Huang CY, Huang CC

  • KMID: 2317070
  • Saf Health Work.
  • 2012 Dec;3(4):257-267.
Occupational neurotoxic diseases have become increasingly common in Taiwan due to industrialization. Over the past 40 years, Taiwan has transformed from an agricultural society to an industrial society. The most...
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