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Improvement of Eosinophilic Otitis Media by Optimized Asthma Treatment

Tanaka Y, Nonaka M, Yamamura Y, Tagaya E, Pawankar R, Yoshihara

Eosinophilic otitis media (EOM) shows a very high rate of association with asthma, and intractable otitis media involves marked eosinophil infiltration into the middle ear. The middle ear space is...
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Basophils are increased and express increased levels of interleukin-4 in the parotid lesions of Kimura disease

Nonaka M, Sakitani E, Ono E, Yamamura Y, Seo Y, Shibata N, Pawankar R, Yoshihara

BACKGROUND: Kimura disease (KD) is a systemic soft-tissue disease that leads to formation of painless masses in lymph nodes, with the highest predilection for the head and neck and especially...
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Optimal control of asthma improved eosinophilic otitis media

Seo Y, Nonaka M, Yamamura Y, Pawankar R, Tagaya E

BACKGROUND: Eosinophilic otitis media (EOM) is often associated with comorbid asthma. The middle ear cavity is part of the upper airway. Therefore, EOM and asthma can be considered to be...
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Abusive Head Trauma in Infants and Children in Japan

Nonaka M, Asai A

Subdural hematoma in infants can be caused by abuse, and is thought to be more likely if subdural hematoma is associated with retinal hemorrhage and cerebral edema. In Japan, few...
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Safety of Gastroenterologist-Guided Sedation with Propofol for Upper Gastrointestinal Therapeutic Endoscopy in Elderly Patients Compared with Younger Patients

Nonaka M, Gotoda T, Kusano C, Fukuzawa M, Itoi T, Moriyasu F

BACKGROUND/AIMS: Propofol sedation for elderly patients during time-consuming endoscopic procedures is controversial. Therefore, we investigated the safety of using propofol in elderly patients during upper gastrointestinal therapeutic endoscopy. METHODS: The medical...
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Increased Expression and Role of Thymic Stromal Lymphopoietin in Nasal Polyposis

Kimura S, Pawankar R, Mori S, Nonaka M, Masuno S, Yagi T, Okubo K

PURPOSE: Nasal polyposis is a chronic inflammatory disease of the upper airways often associated with asthma and characterized by markedly increased numbers of eosinophils, Th2 type lymphocytes, fibroblasts, goblet cells...
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Decreased Expression of FOXP3 in Nasal Polyposis

Roongrotwattanasiri K, Pawankar R, Kimura S, Mori S, Nonaka M, Yagi T

PURPOSE: The pathogenesis of nasal polyposis (NP) is unclear. Eosinophils and mast cells are considered to play important roles in this process. In addition, the levels of Th2-type cells are...
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Expression and Roles of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 in Allergic Nasal Mucosa

Mori S, Pawankar R, Ozu C, Nonaka M, Yagi T, Okubo K

PURPOSE: Allergic rhinitis (AR) and asthma share many characteristics, but structural changes are observed far less often in AR. Matrix metalloproteinases (MMPs) constitute a family of Zn-dependent endopeptidases that can...
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Randomized phase III trial comparing pegylated liposomal doxorubicin (PLD) at 50 mg/m2 versus 40 mg/m2 in patients with platinum-refractory and -resistant ovarian carcinoma: the JGOG 3018 Trial

Motohashi T, Yabuno A, Michimae H, Ohishi T, Nonaka M, Takano M, Nishio S, Fujiwara H, Keiichi K, Kondo E, Sugiyama T, Tabata T

Objective: The standard dose for pegylated liposomal doxorubicin (PLD) is 50 mg/m2 every 4 weeks. While 40 mg/m2 has recently been used in clinical practice, evidence supporting this use remains...
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Generation of Induced Pluripotent Stem Cells and Neural Stem/Progenitor Cells from Newborns with Spina Bifida Aperta

Bamba Y, Nonaka M, Sasaki N, Shofuda T, Kanematsu , Suemizu H, Higuchi Y, Pooh RK, Kanemura Y, Okano H, Yamasaki M

STUDY DESIGN: We established induced pluripotent stem cells (iPSCs) and neural stem/progenitor cells (NSPCs) from three newborns with spina bifida aperta (SBa) using clinically practical methods. PURPOSE: We aimed to develop...
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