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Role of Nitric Oxide on the Proliferation of Human Tenon Capsule Fibroblasts

Kim KH, Kim JW

  • KMID: 2125582
  • J Korean Ophthalmol Soc.
  • 2003 Jul;44(7):1670-1674.
PURPOSE: To investigate the role of nitric oxide(NO) on the survival and proliferation of human Tenon capsule fibroblasts(HTCF) in tissue culture. METHODS: Following exposure to NO donor such as sodium...
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The Ototoxicity of Cisplatin is Mediated by NO: A Study using L-NAME and MK-801 in Guinea pigs

Rhee CK, Oh YH, Jeon SJ, Chung SY, Oh CH

  • KMID: 2275942
  • Korean J Otolaryngol-Head Neck Surg.
  • 2002 Aug;45(8):741-746.
BACKGROUND AND OBJECTIVES: Nitric oxide has been suggested to play an important role in the pathogenesis of cisplatin ototoxicity. L-NAME (NG-Nitroarginine Methyl Ester) is an inhibitor of nitric oxide synthase....
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Nitric Oxide-Mediated Neurotoxicity after Excimer Laser Photorefractive Keratectomy

Joo MJ, Lee KJ, Shin KH, Kim JC

  • KMID: 2205473
  • J Korean Ophthalmol Soc.
  • 1999 Mar;40(3):688-698.
The aim of this study was to evaluate neurotoxicity of Nitric oxide(NO) on cornea after excimer laser photorefractive keratectomy(PRK). PRK was performed on rabbit eyes. According to the time table,...
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Effect of Nitric Oxide on the Permeability of Trabecular Meshwork Cell Monolayer

Kim HY, Kim JW

PURPOSE: To investigate the effects of nitric oxide (NO) on the permeability of cultured human trabecular meshwork cell (HTMC) monolayer. METHODS: HTMCs were cultured until confluency in the Transwell inner chamber...
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Differential effects of nitric oxide synthase inhibitors in rats

Lee JH, Shin CY, Kang BS, Jeong JH, Choi KB, Min YS, Kim JH, Huh IH, Sohn UD

  • KMID: 1982595
  • Korean J Physiol Pharmacol.
  • 2000 Apr;4(2):99-104.
We investigated the action of NOS inhibitors on NOS in rats. Both of nitric oxide synthase inhibitors, NG-monomethyl-L-arginine (L-NMMA, 3 micrometer) or NG-nitro-L-arginine methylester (L-NAME, 30 micrometer), augmented phenylephrine (PE, 10-7 M)-induced contraction...
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Effect of NG-nitro-L-arginine Methyl Ester Pretreatment on Spinal Cord Damage by Aortic Occlusion in Rabbits

Lee JY, Min JH, Kim DU, Park CJ

BACKGROUND: Production of nitric oxide (NO) radicals may contribute to neuronal injury. We examined that the inhibition of NO synthase (NOS) could improve postischemic neurologic outcome after spinal cord ischemia...
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Effect of NG-nitro-L-arginine methyl ester and Methylene Blue on the Endotoxin-induced Vascular Hyporesponsiveness

Choi HC, Ha JH, Lee KY, Kim WJ, Sohn UD

  • KMID: 2320331
  • Yeungnam Univ J Med.
  • 1997 Dec;14(2):337-349.
The study was undertaken to examine the intensity of involvement of inducible nitric oxide synthase(iNOS) and cyclic GMP signal transduction pathway as one of the mechanisms of vaso-relaxative action of...
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Moderate and Deep Hypothermia Produces Hyporesposiveness to Phenylephrine in Isolated Rat Aorta

Cho JW, Lee CH, Jang JS, Kwon OC, Roh WS, Kim JE

  • KMID: 1987359
  • Korean J Thorac Cardiovasc Surg.
  • 2013 Dec;46(6):402-412.
BACKGROUND: Moderate and severe hypothermia with cardiopulmonary bypass during aortic surgery can cause some complications such as endothelial cell dysfunction or coagulation disorders. This study found out the difference of...
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Role of Nitric Oxide in a Spinal Ligation Model of Neuropathic Pain

Han KC, Lee JZ, Lee YH, Shin YS, Lee WH, Yoon SH

BACKGROUND: The role of NO in neuropathic pain is controversial. The aim of this study was to compare neuropathic pain behavior after a NOS inhibitor or NO donor treatment and...
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Endogenous Nitric Oxide Inhibits Na,K-ATPase Activity in the Kidney

Kim JW, Kang DG

  • KMID: 2172466
  • Chonnam Med J.
  • 1999 Dec;35(4):553-562.
Nitric oxide (NO) has been suggested to play a role in regulating sodium excretion in the kidney. The present study was aimed at investigating the effect of endogenous NO system...
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The Effects of Etomidate on the Isolated Porcine Coronary Artery

Suh JK, Shin WJ, Yeom JH, Cho SY, Jun JH, Kim KH, Shim JC

BACKGROUND: Etomidate produces minimal cardiovascular effects in clinical uses but their effects on the porcine coronary arteries are not well known yet. We studied the direct effects of etomidate on...
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Effects of Ginseng Saponin on the Stress-Induced Plasma Corticosterone Levels in Mice

Kim DH, Min SK, Son BK, Lee SK, Song DK

  • KMID: 2340669
  • J Korean Neuropsychiatr Assoc.
  • 2002 May;41(3):389-398.
OBJECTIVES: The present study was designed to investigate the effect of ginseng saponin and its major active metabolite on the HPA axis under acute stress-i.c.v. injection stress, and immobilization stress,...
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Effect of Nitric Oxide on the Survival of R28 Cells

Lee JI, Kim JW

PURPOSE: To evaluate the effect of nitric oxide (NO) on the survival of R28 cells. METHODS: After immunostaining for GFAP, vimentin, S-100, and neurofilament, R28 cells were exposed to S-nitroso-N-acetyl-D, L-penicillamine...
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Effects of Nitric Oxide Synthesis Inhibition on the Blood Pressure Response to Bradykinin in Rats

Yeum CH, Yang MJ, Jun JY, Yoon PJ, Moon SH, Kim JH, Lee JU

  • KMID: 2079020
  • Korean J Nephrol.
  • 1998 Sep;17(5):667-672.
Bradykinin has been known to elicit a pressor effect when administered centrally, and a depressor effect when administered peripherally. The present study was aimed at investigating whether the blood pressure...
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Effects of Vecuronium and Pancuronium on the Tension of the Smooth Muscle in the Rat Trachea

Kim SS, Son YS, Kim YH, Yoon SH, Lee JU, Kim HJ

BACKGROUND: Vecuronium and Pancuronium have been proven to be associated with nicotinic receptor of skeletal muscle. Generally, nondepolarizing muscle relaxant is associated with contraction of smooth tracheal muscle, but there...
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Effect of Hypoxia on the Survival and Production of Nitric Oxide in Trabecular Meshwork Cells

Jin YH, Kim JW

  • KMID: 2125788
  • J Korean Ophthalmol Soc.
  • 2004 Dec;45(12):2127-2132.
PURPOSE: To investigate the effect of hypoxia on the survival and nitric oxide (NO) production of cultured trabecular meshwork (TM) cells. METHODS: After inducing chemical hypoxia with sodium cyanide, the...
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Mechanism of L-NAME-resistant endothelium-dependent relaxation induced by acetylcholine in rabbit renal artery

Yeon DS, Ahn DS, Lee YH, Kwon SC

  • KMID: 1581025
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):471-477.
In the rabbit renal artery, acetylcholine (ACh, 1 nM ~ 10 micrometer) induced endothelium-dependent relaxation of arterial rings precontracted with norepinephrine (NE, 1 micrometer) in a dose-dependent manner. NG-nitro-L-arginine (L-NAME, 0.1 mM), an...
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The Effect of Nitric Oxide on Mechanical and Theraml Allodynia in Neuropathic Pain Model of Rat

Kim SH, Jung SJ

  • KMID: 2195075
  • J Korean Neurol Assoc.
  • 2003 Jun;21(3):283-288.
BACKGROUND: Nitric oxide (NO) is known to play causative role in the development of neuropathic pain following peripheral nerve injury. However, it is yet to be investigated whether the role...
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N-Acetylcysteine and N-Nitroarginine Methyl Ester Attenuate Carboplatin-Induced Ototoxicity in Dissociated Spiral Ganglion Neuron Cultures

Moon IJ, Kim KR, Chu HS, Kim SH, Chung WH, Cho YS, Hong SH

  • KMID: 2166455
  • Clin Exp Otorhinolaryngol.
  • 2011 Mar;4(1):11-17.
OBJECTIVES: Carboplatin, a platinum-containing anti-cancer drug used to treat a variety of cancers, induces ototoxicity. Since, reactive oxygen species (ROS) and nitric oxide (NO) seem to be responsible for this...
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The Effects of Mivacurium on Isolated Rat Tracheal Muscle

Ko YK, Lee JU, Shin YS, Son SC, Lee WH, Choi SJ

BACKGROUND: Neuromuscular blocking drugs are designed to specifically block nicotinic cholinergic receptors at the neuromuscular junction, but many bind to muscarinic cholinergic receptors on ganglia, nerve endings, and smooth muscles,...
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