- EFMDR-Fast: An Application of Empirical Fuzzy Multifactor Dimensionality Reduction for Fast Execution
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Leem S, Park T
- KMID: 2439227
- Genomics Inform.
- 2018 Dec;16(4):e37.
- doi: 10.5808/GI.2018.16.4.e37
Gene-gene interaction is a key factor for explaining missing heritability. Many methods have been proposed to identify gene-gene interactions. Multifactor dimensionality reduction (MDR) is a well-known method for the detection... -
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- Gene-Gene Interaction Analysis for the Accelerated Failure Time Model Using a Unified Model-Based Multifactor Dimensionality Reduction Method
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Lee S, Son D, Yu W, Park T
- KMID: 2366432
- Genomics Inform.
- 2016 Dec;14(4):166-172.
- doi: 10.5808/GI.2016.14.4.166
Although a large number of genetic variants have been identified to be associated with common diseases through genome-wide association studies, there still exits limitations in explaining the missing heritability. One... -
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- Network Graph Analysis of Gene-Gene Interactions in Genome-Wide Association Study Data
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Lee S, Kwon MS, Park T
- KMID: 2053306
- Genomics Inform.
- 2012 Dec;10(4):256-262.
- doi: 10.5808/GI.2012.10.4.256
Most common complex traits, such as obesity, hypertension, diabetes, and cancers, are known to be associated with multiple genes, environmental factors, and their epistasis. Recently, the development of advanced genotyping... -
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- Gene-Gene Interaction Between CCR3 and Eotaxin Genes: The Relationship With Blood Eosinophilia in Asthma
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Lee JH, Jang AS, Park SW, Kim DJ, Park CS
- KMID: 2166934
- Allergy Asthma Immunol Res.
- 2014 Jan;6(1):55-60.
- doi: 10.4168/aair.2014.6.1.55
PURPOSE: Eosinophils function as an effector cell in the development of asthma and allergic disease. Eotaxins are cytokines that promote pulmonary eosinophilia via the receptor CCR3. Single-nucleotide polymorphisms (SNPs) in... -
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- Lack of Association between Glutathione S-Transferase-M1, -T1, and -P1 Polymorphisms and Olanzapine-Induced Weight Gain in Korean Schizophrenic Patients
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Park YM, Lee HJ, Kang SG, Choi JE, Cho JH, Kim L
- KMID: 2315881
- Psychiatry Investig.
- 2010 Jun;7(2):147-152.
OBJECTIVE: Oxidative stress may be an important pathogenic mechanism in the obesity and metabolic syndrome. The aims of this study was to assess the possible association between the oxidative stress... -
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- The Interaction Between Allelic Variants of CD86 and CD40LG: A Common Risk Factor of Allergic Asthma and Rheumatoid Arthritis
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Lee SH, Lee EB, Shin ES, Lee JE, Cho SH, Min KU, Park HW
- KMID: 2260258
- Allergy Asthma Immunol Res.
- 2014 Mar;6(2):137-141.
- doi: 10.4168/aair.2014.6.2.137
PURPOSE: Allergic asthma (AA) and rheumatoid arthritis (RA) are immune tolerance-related diseases, and immune tolerance is known to be influenced by costimulatory molecules. In this study, we sought to identify... -
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- Genome-Wide Association Scan of Korean Autism Spectrum Disorders with Language Delay: A Preliminary Study
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Cho SC, Yoo HJ, Park M, Cho IH, Kim BN, Kim JW, Shin MS, Park TW, Son JW, Chung US, Kim HW, Yang YH, Kang JO, Yang SY, Kim SA
- KMID: 2315930
- Psychiatry Investig.
- 2011 Mar;8(1):61-66.
OBJECTIVE: Communication problems are a prevalent symptom of autism spectrum disorders (ASDs), which have a genetic background. Although several genome-wide studies on ASD have suggested a number of candidate genes,... -
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- The FOXO1 Gene-Obesity Interaction Increases the Risk of Type 2 Diabetes Mellitus in a Chinese Han Population
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Gong L, Li R, Ren W, Wang Z, Wang Z, Yang M, Zhang S
- KMID: 2364170
- J Korean Med Sci.
- 2017 Feb;32(2):264-271.
- doi: 10.3346/jkms.2017.32.2.264
Here, we aimed to study the effect of the forkhead box O1-insulin receptor substrate 2 (FOXO1-IRS2) gene interaction and the FOXO1 and IRS2 genes-environment interaction for the risk of type... -
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