- The effect of a factor produced from phytohaemagglutinin-stimulated T cells on the neutrophil viability, superoxide production and leukotriene C4 release
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Her E, Yang YM
- KMID: 2082985
- Korean J Immunol.
- 1993 Nov;15(2):191-199.
No abstract available. -
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- Association of Leukotriene C4 Synthase Gene Polymorphism with Clinical Response to Montelukast in Childhood Asthma
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Shin KS, Kim YW
- KMID: 1855968
- Korean J Pediatr.
- 2005 Jul;48(7):766-771.
PURPOSE: Cysteinyl leukotrienes are important inflammatory mediators in the pathogenesis of asthma; therefore interruption of cysteinyl leukotrienes by leukotriene receptor antagonists improves clinical symptoms in the management of patients with... -
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- Effect of theophylline on urinary leukotriene B4 and C4 excretion in children with asthma
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Chung HL, Lee JJ, Kim SG
- KMID: 2054865
- J Asthma Allergy Clin Immunol.
- 2000 Oct;20(5):710-716.
BACKGROUND: Theophylline has been used in the treatment of asthma for decades as a broncho- dilator, but recent studies suggested that it has anti-inflammatory and immunomodulatory properties. OBJECTIVE: The aim... -
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- Association study of polymorphism in leukotriene C4 synthase and cysteinyl leukotriene receptor 1 genes with phenotype of asthma and clinical parameters in Korean children
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Shim JY, Kim BJ, Song YH, Kang MJ, Lee SY, Kim HB, Yu J, Hong SJ
- KMID: 2281073
- Korean J Pediatr.
- 2009 Jun;52(6):680-688.
- doi: 10.3345/kjp.2009.52.6.680
PURPOSE: Cysteinyl leukotrienes are important proinflammatory mediators in asthma. Recently, it was suggested that a promoter polymorphism in the genes encoding for leukotriene C4 synthase (LTC4S), a key enzyme in... -
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- Leukotriene C4 synthase promoter polymorphism in aspirin - induced asthma
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Cho JY, Lee SY, Han SA, Yoo SH, Kim SS, Park HS, Park JW, Hong CS, In KH
- KMID: 2054840
- J Asthma Allergy Clin Immunol.
- 1999 Aug;19(4):542-547.
BACKGROUND: Aspirin/NSAIDs can release cysteinyl-leukotriene (cys-LTs) into airways and precipitate asthmatic symptoms in aspirin - induced asthma(AIA). It has been reported that there is profound overexpression of LTC4 synthase in... -
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- Mast Cells and Allergic Rhinitis
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Cho JS
- KMID: 2297727
- J Rhinol.
- 1998 Nov;5(2):85-91.
That mast cells play a role in acute allergic inflammation by releasing various inflammatory mediators, including histamine, leukotrienes (LT), such as LTC4 and LTD4, and prostaglandins (PG), such as PGD2,... -
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- Molecular Genetic Mechanisms of Chronic Urticaria
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Losol P, Yoo HS, Park HS
- KMID: 2166923
- Allergy Asthma Immunol Res.
- 2014 Jan;6(1):13-21.
- doi: 10.4168/aair.2014.6.1.13
Chronic urticaria (CU) is a common allergic skin disease that requires long-term pharmacological treatment. Some patients with severe CU suffer a poor quality of life. Although the pathogenic mechanisms of... -
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- The Effect of Nimodipine on the Content of Leukotriene C4 in Brain Tissue after Experimental Subarachnoid Hemorrhage in Rats
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Park IW, Yim MB, Lee JC, Park BK, Son EI, Kim DW, Kim IH, Lee IK
- KMID: 2067939
- J Korean Neurosurg Soc.
- 1992 Sep;21(9):1138-1146.
In order to find out whether a calcium entry blocker, nimodipine, prevents or decreases the arachnoid acid(AA) metabolism of the brain cell membrane after a subarachnoid hemorrhage(SAH), in a series... -
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- Imperatorin Suppresses Degranulation and Eicosanoid Generation in Activated Bone Marrow-Derived Mast Cells
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Jeong KT, Lee E, Park NY, Kim SG, Park HH, Lee J, Lee YJ, Lee E
- KMID: 2380290
- Biomol Ther.
- 2015 Sep;23(5):421-427.
- doi: 10.4062/biomolther.2015.023
Imperatorin has been known to exert many biological functions including anti-inflammatory activity. In this study, we investigated the inhibitory effects of imperatorin on the production of inflammatory mediators in mouse... -
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- Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels
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Li X, Lu Y, Jin Y, Son JK, Lee SH, Chang HW
- KMID: 2048327
- Biomol Ther.
- 2014 Jan;22(1):27-34.
Curcumin is naturally occurring polyphenolic compound found in turmeric and has many pharmacological activities. The present study was undertaken to evaluate anti-allergic inflammatory activity of curcumin, and to investigate its... -
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- The Cerebrospinal Fluid Levels of Leukotriene C4 in Patients with aneurysmal subarachnoid hemorrhage
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Lee JS, Yim MB, Son EI, Kim DW, Kim IH, Lee IK
- KMID: 1673472
- J Korean Neurosurg Soc.
- 1990 Feb;19(2):197-206.
We have checked levels of leukotriene(LT) C4, one of the arachidonic acid(AA) metabolites, in the lumbar, cisternal and ventricular cerebrospinal fluid(CSF) of 37 patients admitted with diagnosis of aneurysmal subarachnoid... -
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- Leukotriene related gene polymorphisms in ASA-intolerant asthma: an association of 5-lipoxygenase haplotype
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Choi JH, Park HS, Shin SS, Oh HB, Lee JH, Suh YJ, Park CS, Shin HD
- KMID: 2178419
- J Asthma Allergy Clin Immunol.
- 2003 Dec;23(4):800-809.
BACKGROUND AND OBJECTIVES: A recent study has demonstrated a possible involvement of leukotriene C4 synthase (LTC4S) gene polymorphism in ASA-intolerant asthma (AIA) in a Polish population, while no significances were... -
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- Effects of ATP and LTC4 on hypoxic pulmonary vasoconstriction in isolated rat lungs
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Rho JY, Shin HY, Kim HC, Lee JW, Kim SD
- KMID: 1765452
- Korean J Anesthesiol.
- 2009 Oct;57(4):472-482.
- doi: 10.4097/kjae.2009.57.4.472
BACKGROUND: Hypoxic pulmonary vasoconstriction (HPV) is unique to pulmonary circulation but the mechanism remains elusive. Red blood cells (RBCs) are known to augment HPV and to release more ATP as... -
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- Simultaneous HPLC analysis of arachidonic acid metabolites in biological samples with simple solid phase extraction
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Kim HG, Huh YN, Park KS
- KMID: 2071837
- Korean J Physiol Pharmacol.
- 1998 Dec;2(6):779-786.
A reversed-phase high-performance liquid chromatography (RP-HPLC) has been developed to analyze the metabolites of arachidonic acid based on the specificities of ultraviolet absorption of these various metabolites and is sensitive to the nanogram... -
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- Imidacloprid inhibits IgE-mediated RBL-2H3 cell degranulation and passive cutaneous anaphylaxis
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Shi L, Zou L, Gao J, Xu H, Shi X, Chen H
- KMID: 2397020
- Asia Pac Allergy.
- 2016 Oct;6(4):236-244.
- doi: 10.5415/apallergy.2016.6.4.236
BACKGROUND: Imidacloprid has been commonly used as a pesticide for crop protection and acts as nicotinic acetylcholine receptor agonists. Little information about the relationship between imidacloprid and allergy is available. OBJECTIVE:... -
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- Association of Polymorphism in the Promoter Area of Leukotriene C4 Synthase Gene with Aspirin-Intolerant Asthma
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- KMID: 1850196
- Korean J Asthma Allergy Clin Immunol.
- 2006 Jun;26(2):115-121.
BACKGROUND: The 5-lipoxygenase, 5-lipoxygenase associated protein and leukotriene C4 (LTC4) synthase are enzymes involved in the synthesis of cysteinyl leukotrienes which are known to be important lipid mediators for the... -
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- House dust mite dose not directly activate the human peripheral blood eosinophils in house dust mite-sensitized asthmatics
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Kim MK
- KMID: 1543165
- Korean J Allergy.
- 1997 Jun;17(2):141-150.
In asthma, eosinophil roles as main end inflammatory effector cell, but neither the activation process nor the stimuli of that is known clearly, yet. Even though allergic asthma is IgE-mediated... -
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- Effects of pranlukast on ovalbumin induced early-phase bronchoconstriction in guinea pigs
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Lee SH, Shim JJ, Kim KK, Jeong HC, Kwon YH, Kim JH, Lee SY, Lee SR, Lee SY, Cho JY, In KH, Yoo SH, Kang KH
- KMID: 2050133
- Tuberc Respir Dis.
- 1999 May;46(5):697-708.
- doi: 10.4046/trd.1999.46.5.697
BACKGROUND: Leukotriene (LT) C4, D4, and E4, the main components of slow-reacting substance of anaphylaxis (SRS-A), have been suggested to play an important role in bronchial asthma such as antigen-... -
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- Effects of Azelastine in the treatment of Patients with Chronic Bronchial Asthma
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Cho SH, Kim WK, Yoon HJ, Min KU, Kim YY
- KMID: 1970664
- Allergy.
- 1994 Mar;14(1):42-47.
Azelastine is an orally effective and long acting antiallergic agent with bronchodilating effect which has recently been developed for the treatment of bronchial asthma. Its properties have been described as... -
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- Comparative study on the activation status of eosinophils in exerise- and allergen-induced asthma
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Koh YY, Choi JH, Park CH, Lee SY, Kim CK, Jeong JH
- KMID: 2092967
- Korean J Allergy.
- 1997 Sep;17(3):286-298.
Exercise is one of the most ubiquitous triggers of acute bouts of asthma. Late asthmatic responses(LARs) have been described following strenuous exercise, as in allergen-induced asthma. However, most studies have... -
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