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Comparative study of liver injury induced by high-fat methionine- and choline-deficient diet in ICR mice originating from three different sources

Lee S, Kwak JH, Kim SH, Jeong TB, Son SW, Kim JH, Lim Y, Cho JY, Hwang DY, Kim KS, Jung YS

  • Lab Anim Res.
  • 2019 Aug;35(2):100-106.
  • doi: 10.1186/s42826-019-0016-y
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. It is characterized by the accumulation of lipids without alcohol intake and often progresses to non-alcoholic...
Correlation between synthesis of α2-macroglobulin as acute phase protein and degree of hepatopathy in rats

Ito R, Kuribayashi T

  • Lab Anim Res.
  • 2019 Aug;35(2):94-99.
  • doi: 10.1186/s42826-019-0014-0
The degree of hepatopathy affecting the synthesis of α2-macroglobulin (α2M) as an acute phase protein in rats was investigated. Hepatopathy was induced in Sprague-Dawley rats by intravenous administration of galactosamine...
The effects of coenzyme Q₁₀ supplement on blood lipid indices and hepatic antioxidant defense system in SD rats fed a high cholesterol diet

Kim HN, Jeon DG, Lim Y, Jang IS

  • Lab Anim Res.
  • 2019 Aug;35(2):86-93.
  • doi: 10.1186/s42826-019-0013-1
A total of 24 SD rats were allotted to four treatment groups such as the control (CON), 1% of cholesterol diet (CHO), 0.5% of coenzyme Q₁₀ (COQ) and 1% of...
RbAp48 expression and neuronal damage in the gerbil hippocampus following 5 min of transient ischemia

Park JH, Lee TK, Kim DW, Park CW, Park YE, Kim B, Lee JC, Lee HA, Won MH, Ahn JH

  • Lab Anim Res.
  • 2019 Aug;35(2):78-85.
  • doi: 10.1186/s42826-019-0011-3
Histone-binding protein RbAp48 has been known to be involved in histone acetylation, and epigenetic alterations of histone modifications are closely associated with the pathogenesis of ischemic reperfusion injury. In the...
Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources

Seo MS, Kim YI, Kang KK, Oh SK, Sung SE, Jung YS, Cho JY, Song H, Hwang DY, Park SJ, Kim KS

  • Lab Anim Res.
  • 2019 Aug;35(2):70-77.
  • doi: 10.1186/s42826-019-0010-4
Botulinum-toxin A (BoNT/A) is a widely used not only for cosmetics but also for various experimental purposes including muscle-related research. In this study, we applied BoNT/A to mouse muscle of...
Comparative analysis of dose-dependent neurotoxic response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 N mice derived from three different sources

Hwang DJ, Kwon KC, Song HK, Kim KS, Jung YS, Hwang DY, Cho JY

  • Lab Anim Res.
  • 2019 Aug;35(2):61-69.
  • doi: 10.1186/s42826-019-0012-2
MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is commonly used to induce nigrostriatal defects to induce parkinsonism and/or parkinsonian syndrome, to replicate the lesions seen in Parkinson's disease (PD), with use in numerous PD models...
Metabolomics approach to serum biomarker for laxative effects of red Liriope platyphylla in loperamide-induced constipation of SD rats

Kim JE, Lee YJ, Ryu SH, Park JW, Kang MJ, Choi HJ, Bae SJ, Choi Y, Kang HG, Kim KB, Kim S, Lim Y, Hwang DY

  • Lab Anim Res.
  • 2019 Aug;35(2):52-60.
  • doi: 10.1186/s42826-019-0009-x
Red Liriope platyphylla (RLP) is a known herbal medicine used in the treatment of some chronic diseases including constipation, neurodegenerative disorders, diabetes and obesity. To determine and characterize putative biomarkers...
Aged mice show an increased mortality after anesthesia with a standard dose of ketamine/xylazine

Schuetze S, Manig A, Ribes S, Nau R

  • Lab Anim Res.
  • 2019 Aug;35(2):45-51.
  • doi: 10.1186/s42826-019-0008-y
Geriatric animal models are crucial for a better understanding and an improved therapy of age-related diseases. We observed a high mortality of aged mice after anesthesia with a standard dose...
Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta) anesthetized with ketamine hydrochloride

Koo BS, Lee DH, Kang P, Jeong KJ, Lee S, Kim K, Lee Y, Huh JW, Kim YH, Park SJ, Jin YB, Kim SU, Kim JS, Son Y, Lee SR

  • Lab Anim Res.
  • 2019 Aug;35(2):39-44.
  • doi: 10.1186/s42826-019-0006-0
Nonhuman primate models are valuable in biomedical research. However, reference data for clinical pathology parameters in cynomolgus and rhesus monkeys are limited. In the present study, we established hematologic and...
Tracking acute phase protein response during acute and chronic Toxoplasma gondii infection

Atmaca HT, Gazyagci A, Terzi OS, Dincel GC, Sumer T

  • Lab Anim Res.
  • 2019 Aug;35(2):30-38.
  • doi: 10.1186/s42826-019-0007-z
Toxoplasmosis is a disease caused by the protozoan Toxoplasma gondii, which occurs worldwide in mammals and birds. Brain is the primary target organ because Toxoplasma gondii is a ubiquitous intracellular...

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