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Experimental Annulotomy-induced Degeneration in Rabbit Intervertebral Discs: Comparative Study Between Incomplete and Complete Annulotomy

Park YS, Cho JL, Kostuik JP

  • KMID: 2399064
  • J Korean Orthop Assoc.
  • 2003 Oct;38(6):619-623.
PURPOSE: To develop an animal disc degeneration model. MATERIALS AND METHODS: 12 female 8-month-old white New Zealand rabbits, weighing about 4-4.5 kg, were used. A retroperitoneal approach using a paravertebral...
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Comparative Study of Disc Degeneration According to the Annulotomy Methodology: In Vivo Animal Study

Park YS, Cho JL, Leong KW, Kostuik JP

STUDY DESIGN: An in-vivo experiment. OBJECTIVES: To compare the results of various methodologies for an annulotomy, and evaluate the relationship between the degenerative change and the volume of an extruded nucleus...
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Spinal Fusion by Percutaneous OP-1 Gene Delivery

Park YS, Bright C, Cho JL, Leong KW, Kostuik JP

  • KMID: 2322994
  • J Korean Soc Spine Surg.
  • 2003 Dec;10(4):283-289.
STUDY DESIGN: An in-vivo experiment. OBJECTIVES: To evaluate the feasibility of achieving bone formation by percutaneous gene delivery, with plasmid DNA encoding BMP-7(OP-1). SUMMARY OF LITERATURE REVIEW: Currently, the preferred method for...
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