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Interleukin-10 and interleukin-5 balance in patients with active asthma, those in remission, and healthy controls

Tomiita M, Campos-Alberto E, Shima M, Namiki M, Sugimoto K, Kojima H, Watanabe H, Sekine K, Nishimuta , Kohno Y, Shimojo N

BACKGROUND: The immunological mechanisms of asthma remission remain unclear although several reports have suggested that balance between T helper (Th) 2 cytokines and regulatory cytokines is related. OBJECTIVE: To study the...
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Pranlukast reduces asthma exacerbations during autumn especially in 1- to 5-year-old boys

Morita Y, Campos Alberto E, Suzuki S, Sato Y, Hoshioka A, Abe H, Saito K, Tsubaki T, Haraki M, Sawa A, Nakayama Y, Kojima H, Shigeta M, Yamaide F, Kohno Y, Shimojo N

BACKGROUND: Leukotriene receptor antagonists have been used to prevent virus-induced asthma exacerbations in autumn. Its efficacy, however, might differ with age and sex. OBJECTIVE: This study aimed to investigate whether pranlukast...
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