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Nutrient-Based Appetite Regulation

Moris JM, Heinold C, Blades A, Koh Y

Regulation of appetite is dependent on crosstalk between the gut and the brain, which is a pathway described as the gut-brain axis (GBA). Three primary appetite-regulating hormones that are secreted...
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IDH1/2 mutations in acute myeloid leukemia

Byun JM, Yoo SJ, Kim HJ, Ahn JS, Koh Y, Jang JH, Yoon SS

The mutational and epigenetic landscape of acute myeloid leukemia (AML) has become increasingly well understood in recent years, informing on biological targets for precision medicine. Among the most notable findings...
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Problems Related to the Act on Decisions on Life-Sustaining Treatment and Directions for Improvement

Heo DS, Yoo SH, Keam B, Yoo SH, Koh Y

The Act on Decisions on Life-Sustaining Treatment has been in effect since 2018 for endof-life patients. However, only 20~25% of deaths of terminally ill patients comply with the law, while...
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Engineering Brain Organoids: Toward Mature Neural Circuitry with an Intact Cytoarchitecture

Jang H, Kim SH, Koh Y, Yoon KJ

The emergence of brain organoids as a model system has been a tremendously exciting development in the field of neuroscience. Brain organoids are a gateway to exploring the intricacies of...
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Eltrombopag for Post-Transplant Poor Graft Function in East Asian Patients

Ahn HJ, Byun JM, Kim I, Youk J, Koh Y, Shin DY, Hong J, Yoon SS

Poor graft function (PGF) is a serious, potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation. Eltrombopag has shown multilineage responses in patients with refractory severe aplastic anemia, supporting the...
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Primary Hepatic Neuroendocrine Tumor Arising at a Young Age: Rare Case Report and Literature Review

Song S, Koh Y

Neuroendocrine tumors (NETs) are low-grade malignancies arising from neuroendocrine cells. Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare and difficult to differentiate from other liver tumors, such as hepatocellular carcinoma...
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Multicenter retrospective analysis of patients with chronic lymphocytic leukemia in Korea

Yi JH, Lee GW, Lee JH, Yoo KH, Jung CW, Kim DS, Lee JO, Eom HS, Byun JM, Koh Y, Yoon SS, Kim JS, Kong JH, Yhim HY, Yang DH, Yoon DH, Lim DH, Lee WS, Shin HJ

Background Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia in Western countries but is rare in the East Asian countries. Due to its rarity and the lack...
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Romiplostim plus danazol as salvage treatment for eltrombopag refractory immune thrombocytopenia: a retrospective pilot study

Nam CH, Byun JM, Shin DY, Hong J, Kim I, Yoon SS, Koh Y

No abstract available
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Effects of high-flow nasal cannula in patients with mild to moderate hypercapnia: a prospective observational study

Nam KH, Kang HK, Lee SS, Park SH, Kang SW, Hwang JJ, Park SY, Kim WY, Suh HJ, Kim EY, Seo GJ, Koh Y, Hong SB, Huh JW, Lim CM

Background: Evidence for using high-flow nasal cannula (HFNC) in hypercapnia is still limited. Most of the clinical studies had been conducted retrospectively, and there had been conflicting reports for the...
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Erratum to “Global and regional ventilation during high flow nasal cannula in patients with hypoxia”

Lee DH, Kim EY, Seo GJ, Suh HJ, Huh JW, Hong SB, Koh Y, Lim CM

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Genomics of diffuse large B cell lymphoma

Koh Y

Next generation sequencing (NGS) technology has revealed the heterogeneity of diffuse large B-cell lymphoma (DLBCL) from a mutation perspective. Accordingly, the conventional cell of origin-based classification of DLBCL has changed...
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Recent Clinical Update of Acute Myeloid Leukemia: Focus on Epigenetic Therapies

Lee E, Koh Y, Hong J, Eom HS, Yoon SS

Acute myeloid leukemia (AML) is a complicated disease characterized by genetic heterogeneity and simultaneous alterations in multiple genes. For decades, its only curative method has been intensive induction chemotherapy with...
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Leukemic stem cell phenotype is associated with mutational profile in acute myeloid leukemia

Han H, Byun JM, Shin DY, Yoon SS, Koh Y, Hong J, Kim I, Lee C, Yoo H, Yun H, Kim MJ, Cho SI, Seong MW, Park SS

Background/Aims: Understanding leukemic stem cell (LSC) is important for acute myeloid leukemia (AML) treatment. However, association of LSC with patient prognosis and genetic information in AML patients is unclear. Methods: Here...
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Effect of corticosteroid therapy in the early phase of acute respiratory distress syndrome: a propensitymatched cohort study

Baek MS, Lee Y, Hong SB, Lim CM, Koh Y, Huh JW

Background/Aims: It is unclear whether corticosteroid use in patients with acute respiratory distress syndrome (ARDS) improves survival. This study aimed to investigate whether the administration of corticosteroids to patients in...
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Derivation and validation of modified early warning score plus SpO2/FiO2 score for predicting acute deterioration of patients with hematological malignancies

Lee JR, Jung YK, Kim HJ, Koh Y, Lim CM, Hong SB, Huh JW

Background/Aims: Scoring systems play an important role in predicting intensive care unit (ICU) admission or estimating the risk of death in critically ill patients with hematological malignancies. We evaluated the...
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High Cell-Free DNA Levels in Cerebrospinal Fluid Predict Leptomeningeal Seeding of Hematologic Malignancy

Kim EY, Lee ST, Kim YS, Byun JM, Hong J, Shin DY, Koh Y, Kim I

Background and Purpose: The main difficulty when diagnosing leptomeningeal metastases (LMSs) is the low sensitivity of cytology. Cancer cells release cell-free DNA (cfDNA) during proliferation and apoptosis, and so we...
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Strong association between herpes simplex virus-1 and chemotherapy-induced oral mucositis in patients with hematologic malignancies

Hong J, Park HK, Park S, Lee A, Lee YH, Shin DY, Koh Y, Choi JY, Yoon SS, Choi Y, Kim I

Background/Aims: A link between oral cavity infections and chemotherapy-induced oral mucositis (CIOM) in patients with hematological malignancies (HMs) undergoing intensive chemotherapy (IC) or hematopoietic stem cell transplantation (HSCT) has been...
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AL amyloidosis: advances in diagnosis and management

Koh Y

Light chain (AL) amyloidosis is a disease in which malignant plasma cell clones affect multiple organs including the heart and kidney. The mechanism for organ function deterioration in AL amyloidosis...
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The quick sepsis-related organ failure score has limited value for predicting adverse outcomes in sepsis patients with liver cirrhosis

Son J, Choi S, Huh JW, Lim CM, Koh Y, Kim KM, Shim JH, Lim YS, Hong SB

Background/Aims: The quick Sepsis-related Organ Failure Assessment (qSOFA) is a newly developed risk stratification tool, which has been presented along with a new sepsis definition, to classify infected patients outside...
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Non-nutritive Sweeteners and Their Associations with Obesity and Type 2 Diabetes

Walbolt J, Koh Y

Evidence linking the excessive consumption of nutritive sweeteners (NS) to adverse metabolic health outcomes has led to an increase in consumption of non-nutritive sweeteners (NNS), particularly among the obese and...
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