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Decreased nitric oxide synthesis in rats with chronic renal failure

Kim SW, Lee JU, Paek YW, Kang DG, Choi KC

The present study was aimed at investigating whether an altered role of nitric oxide (NO) is involved in chronic renal failure (CRF). Rats were subjected to 5/6 nephrectomy and kept...
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Role of Sodium Ion in Renal Transport of p-Aminohippurate in vitro

Park YS, Lee SM

The effect of sodium on p-aminohippurate (PAH) transport kinetics was studied in isolated rat kidney slices in an attempt to define the role of sodium ion in renal organic acid...
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Decreased osteopontin expression in the rat kidney on a sodium deficient diet

Cha JH, Ahn YH, Lim SW, Kim YH, Han KH, Jung JY, Kim J

Osteopontin (OPN) is a secreted phosphoprotein that is constitutively expressed in the normal kidney and is induced by various experimental and pathologic conditions. Several possible functions of OPN have been...
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Post-mortem re-cloning of a transgenic red fluorescent protein dog

Hong SG, Koo OJ, Oh HJ, Park JE, Kim M, Kim GA, Park EJ, Jang G, Lee BC

Recently, the world's first transgenic dogs were produced by somatic cell nuclear transfer. However, cellular senescence is a major limiting factor for producing more advanced transgenic dogs. To overcome this...
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Determination of Roxithromycin by Liquid Chromatography/Mass Spectrometry after Multiple-Dose Oral Administration in Broilers

Lim JH, Park BK, Yun HI

  • KMID: 1099819
  • J Vet Sci.
  • 2003 Apr;4(1):35-39.
A highly sensitive and specific method for the determination of roxithromycin in broiler tissues by LC/MS was developed and validated. A dichloromethane extract of the sample was separated on C18...
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A Case Report of a Middle East Respiratory Syndrome Survivor with Kidney Biopsy Results

Cha RH, Yang SH, Moon KC, Joh JS, Lee JY, Shin HS, Kim DK, Kim YS

A 68-year old man diagnosed with Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) presented with multiple pneumonic infiltrations on his chest X-ray, and the patient was placed on a mechanical ventilator because...
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Hypoxia Induces Connective Tissue Growth Factor mRNA Expression

Lee YK, Kim EJ, Lee JE, Noh JW, Kim YG

Connective tissue growth factor (CTGF) is known to be a profibrotic growth factor, which mediate the fibrotic effect of transforming growth factor-beta(TGF-beta) and to stimulate cell proliferation and matrix production....
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Expression of NAD(P)H Oxidase Subunits and Their Contribution to Cardiovascular Damage in Aldosterone/Salt-Induced Hypertensive Rat

Park YM, Lim BH, Touyz RM, Park JB

NAD(P)H oxidase plays an important role in hypertension and its complication in aldosterone-salt rat. We questioned whether NAD(P)H oxidase subunit expression and activity are modulated by aldosterone and whether this...
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Identification of a putative transactivation domain in human Nanog

Oh JH, Do HJ, Yang HM, Moon SY, Cha KY, Chung HM, Kim JH

  • KMID: 1056238
  • Exp Mol Med.
  • 2005 Jun;37(3):250-254.
Nanog is a newly identified divergent homeodomain protein that directs the infinite propagation and sustains the pluripotency of embryonic stem cells. It has been reported that murine Nanog has two...
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PPARgamma Agonist and Angiotensin II Receptor Antagonist Ameliorate Renal Tubulointerstitial Fibrosis

Han JY, Kim YJ, Kim L, Choi SJ, Park IS, Kim JM, Chu YC, Cha DR

The peroxisome proliferator activated receptor (PPAR)gamma agonist is used as antidiabetic agent with antihyperglycemic and antihyperinsulinemic actions. Beyond these actions, antifibrotic effects have been reported. We examined antifibrotic effects of...
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KP Index at the Initiation of Dialysis for Patients with End-stage Renal Disease

Hwang EW, Ji SB, Kim JK, Hwang SD

  • KMID: 759692
  • Korean J Intern Med.
  • 2004 Jun;19(2):81-86.
BACKGROUND: The time at which renal replacement therapy (RRT) is initiated in patients with end-stage renal disease (ESRD) has a great influence on the prognosis of the patient; however, there...
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Post-treatment Effects of Erythropoietin and Nordihydroguaiaretic Acid on Recovery from Cisplatin-induced Acute Renal Failure in the Rat

Lee DW, Kwak IS, Lee SB, Song SH, Seong EY, Yang BY, Lee MY, Sol MY

5-Lipoxygenase inhibitor and human recombinant erythropoietin might accelerate renal recovery in cisplatin-induced acute renal failure rats. Male Sprague-Dawley rats were randomized into four groups: 1) normal controls; 2) Cisplatin group-cisplatin...
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Homocysteine and Fibrinogen Changes with L-thyroxine in Subclinical Hypothyroid Patients

Cakal B, Cakal E, Demirbas B, Ozkaya M, Karaahmetoglu S, Serter R, Aral Y

The aim of the present study was to evaluate plasma total homocysteine (Hcys) and serum fibrinogen concentrations in subclinical hypothyroid (SH) and overt hypothyroid patients before and after L-thyroxine (LT4)...
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Urinary Hypoxia-Inducible Factor-1alpha Levels Are Associated with Histologic Chronicity Changes and Renal Function in Patients with Lupus Nephritis

Ma C, Wei J, Zhan F, Wang R, Fu K, Wan X, Li Z

PURPOSE: Tubulointerstitial hypoxia in the kidney is considered a hallmark of injury and a mediator of the progression of tubulointerstitial fibrosis. Hypoxia-inducible factor-1alpha (HIF-1alpha), a master transcription factor in cellular...
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In vivo targeting of ERGpotassiumchannels inmice and dogs by a positron-emitting analogue of fluoroclofilium

Kim SW, Yang SD, Ahn BJ, Park JH, Lee DS, Gessner G, Heinemann , Herdering , Yu KH

  • KMID: 1093461
  • Exp Mol Med.
  • 2005 Aug;37(4):269-275.
The antiarrhythmic clofilium is an efficient blocker of hERG1 potassium channels that are strongly expressed in the heart. Therefore, derivatives of clofilium that emit positrons might be useful tools for...
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