- Recent Advances in the Development of Novel Drug Candidates for Regulating the Secretion of Pulmonary Mucus
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Li X, Jin F, Lee HJ, Lee CJ
- KMID: 2503468
- Biomol Ther.
- 2020 Jul;28(4):293-301.
- doi: 10.4062/biomolther.2020.002
Hypersecretion of pulmonary mucus is a major pathophysiological feature in allergic and inflammatory respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD). Overproduction and/or oversecretion of mucus cause the... -
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- Diclofenac Inhibits Phorbol Ester-Induced Gene Expression and Production of MUC5AC Mucin via Affecting Degradation of IkBα and Translocation of NF-kB p65 in NCI-H292 Cells
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Jin F, Li X, Lee HJ, Lee CJ
- KMID: 2505688
- Biomol Ther.
- 2020 Sep;28(5):431-436.
- doi: 10.4062/biomolther.2020.090
In this study, diclofenac, a non-steroidal anti-inflammatory drug, was investigated for its potential effect on the gene expression and production of airway MUC5AC mucin. The human respiratory epithelial NCI-H292 cells... -
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- Kaempferol Regulates the Expression of Airway MUC5AC Mucin Gene via IκBα-NF-κB p65 and p38-p44/42-Sp1 Signaling Pathways
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Li X, Jin F, Lee HJ, Lee CJ
- KMID: 2515279
- Biomol Ther.
- 2021 May;29(3):303-310.
- doi: 10.4062/biomolther.2020.149
In the present study, kaempferol, a flavonoidal natural compound found in Polygonati Rhizoma, was investigated for its potential effect on the gene expression and production of airway MUC5AC mucin. A... -
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- The Effect of Luteolin on the Modulation of Vascular Contractility via ROCK and CPI-17 Inactivation
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Yoon HJ, Kang DH, Jin F, Bang JS, Sohn UD, Je HD
- KMID: 2539588
- Biomol Ther.
- 2023 Mar;31(2):193-199.
- doi: 10.4062/biomolther.2022.087
In this investigation, we made a study of the efficacy of luteolin (a flavonoid found in plants such as vegetables, herbs and fruits) on vascular contractibility and to elucidate the... -
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- The Effect of Galangin on the Regulation of Vascular Contractility via the Holoenzyme Reactivation Suppressing ROCK/CPI-17 rather than PKC/CPI-17
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Yoon HJ, Jung WP, Min YS, Jin F, Bang JS, Sohn UD, Je HD
- KMID: 2526816
- Biomol Ther.
- 2022 Mar;30(2):145-150.
- doi: 10.4062/biomolther.2021.087
In this study, we investigated the influence of galangin on vascular contractibility and to determine the mechanism underlying the relaxation. Isometric contractions of denuded aortic muscles were recorded and combined... -
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- LINC00662 Promotes Oral Squamous Cell Carcinoma Cell Growth and Metastasis through miR-144-3p/EZH2 Axis
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Yao Y, Liu Y, Jin F, Meng Z
- KMID: 2516857
- Yonsei Med J.
- 2021 Jul;62(7):640-649.
- doi: 10.3349/ymj.2021.62.7.640
Purpose: Long non-coding RNA (lncRNA) is identified as an important regulator involved in oral squamous cell carcinoma (OSCC) tumorigenesis. This study aimed to investigate the functional role and underlying mechanism... -
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- Significance of Vesicle-Associated Membrane Protein 8 Expression in Predicting Survival in Breast Cancer
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Yuan M, Liao J, Luo J, Cui M, Jin F
- KMID: 2429818
- J Breast Cancer.
- 2018 Dec;21(4):399-405.
- doi: 10.4048/jbc.2018.21.e57
PURPOSE: Vesicle-associated membrane protein 8 (VAMP8) is a soluble N-ethylmaleimide-sensitive factor receptor protein that participates in autophagy by directly regulating autophagosome membrane fusion and has been reported to be involved... -
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- Clinical Significance of C-X-C Motif Chemokine Receptor 4 and Integrin αvβ6 Expression in Breast Cancer
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Huang H, Yuan M, Wu SL, Ba J, Yu X, Mao X, Jin F
- KMID: 2500153
- J Breast Cancer.
- 2020 Apr;23(2):171-181.
- doi: 10.4048/jbc.2020.23.e23
Purpose: C-X-C motif chemokine receptor 4 (CXCR4) and integrin αvβ6 play important roles in the malignant progression of multiple cancers. However, it remains unclear whether the expression of one or... -
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- Betulin, an Anti-Inflammatory Triterpenoid Compound, Regulates MUC5AC Mucin Gene Expression through NF-kB Signaling in Human Airway Epithelial Cells
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Hossain R, Kim Ki, Jin F, Lee HJ, Lee CJ
- KMID: 2534703
- Biomol Ther.
- 2022 Nov;30(6):540-545.
- doi: 10.4062/biomolther.2022.093
Betulin is a triterpenoid natural product contained in several medicinal plants including Betulae Cortex. These medicinal plants have been used for controlling diverse inflammatory diseases in folk medicine and betulin... -
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- Development of a Malignancy Potential Binary Prediction Model Based on Deep Learning for the Mitotic Count of Local Primary Gastrointestinal Stromal Tumors
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Yang J, Chen Z, Liu W, Wang X, Ma S, Jin F, Wang X
- KMID: 2513105
- Korean J Radiol.
- 2021 Mar;22(3):344-353.
- doi: 10.3348/kjr.2019.0851
Objective: The mitotic count of gastrointestinal stromal tumors (GIST) is closely associated with the risk of planting and metastasis. The purpose of this study was to develop a predictive model... -
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