- Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform
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Kim B, Yoon DY, Lee S, Jang IJ, Yu KS, Cho JY, Oh J
- KMID: 2525616
- Transl Clin Pharmacol.
- 2021 Sep;29(3):135-149.
- doi: 10.12793/tcp.2021.29.e14
Genetic polymorphisms of enzymes and transporters associated with the absorption, distribution, metabolism, and elimination (ADME) of drugs are one of the major factors that contribute to interindividual variations in drug... -
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- Pharmacokinetic comparison between a fixed-dose combination of fimasartan/amlodipine/ hydrochlorothiazide 60/10/25 mg and a corresponding loose combination of fimasartan/amlodipine 60/25 mg and hydrochlorothiazide 25 mg in healthy subjects
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Jung J, Lee S, Oh J, Lee S, Jang IJ, Lee D, Yu KS
- KMID: 2525603
- Transl Clin Pharmacol.
- 2021 Mar;29(1):53--64.
- doi: 10.12793/tcp.2021.29.e5
For the treatment of hypertension, fixed-dose combinations (FDCs) of antihypertensive drugs can provide complementary benefits from improved compliance and cost-effectiveness compared with loose combinations of corresponding drugs. A new FDC... -
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- Electronic medical records-based comparison of glycemic control efficacy between sulfonylureas and dipeptidyl peptidase-4 inhibitors added on to metformin monotherapy in patients with type 2 diabetes
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Lee S, Lee S, Jang IJ, Yu KS, Rhee Sj
- KMID: 2512006
- Transl Clin Pharmacol.
- 2020 Dec;28(4):199-207.
- doi: 10.12793/tcp.2020.28.e21
Sulfonylurea (SU) and dipeptidyl peptidase-4 (DPP-4) inhibitors are most common secondary agents that are added to metformin monotherapy. Real-world studies have become increasingly important in providing evidence of treatment effectiveness... -
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- Pharmacogenomic information from CPIC and DPWG guidelines and its application on drug labels
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Yoon DY, Lee S, Ban MS, Jang IJ, Lee S
- KMID: 2512007
- Transl Clin Pharmacol.
- 2020 Dec;28(4):189-198.
- doi: 10.12793/tcp.2020.28.e18
There are several hurdles to overcome before implementing pharmacogenomics (PGx) in precision medicine. One of the hurdles is unawareness of PGx by clinicians due to insufficient pharmacogenomic information on drug... -
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- Pharmacokinetic comparison between fixed-dose combination of fimasartan/amlodipine 60/10 mg and the corresponding loose combination through partial replicated crossover study in healthy subjects
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Yang E, Lee S, Lee H, Hwang I, Jang IJ, Yu KS, Lee S
- KMID: 2467967
- Transl Clin Pharmacol.
- 2019 Dec;27(4):134-140.
- doi: 10.12793/tcp.2019.27.4.134
Combination therapies of antihypertensive drugs are recommended in cases where hypertension is not controlled by monotherapy. This study aimed to compare the pharmacokinetics (PKs) between fixed-dose combination (FDC) of fimasartan/amlodipine... -
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- Artificial intelligence in drug development: clinical pharmacologist perspective
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Jang IJ
- KMID: 2458946
- Transl Clin Pharmacol.
- 2019 Sep;27(3):87-88.
- doi: 10.12793/tcp.2019.27.3.87
No abstract available. -
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- Comparison of the Plasma Metabolome Profiles Between the Internal Thoracic Artery and Ascending Aorta in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Gas Chromatography Time-of-Flight Mass Spectrometry
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Kim JS, Kim AH, Jang C, Jang IJ, Kim KB, Cho JY, Hwang HY
- KMID: 2442638
- J Korean Med Sci.
- 2019 Apr;34(13):e104.
- doi: 10.3346/jkms.2019.34.e104
BACKGROUND: The left internal thoracic artery (LITA) has been used as the first conduit of choice in coronary artery bypass grafting (CABG) because of excellent long-term patency and outcomes. However,... -
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- Assessment of Hepatic Cytochrome P450 3A Activity Using Metabolic Markers in Patients with Renal Impairment
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Kim AH, Yoon S, Lee Y, Lee J, Bae E, Lee H, Kim DK, Lee S, Yu KS, Jang IJ, Cho JY
- KMID: 2429888
- J Korean Med Sci.
- 2018 Dec;33(53):e298.
- doi: 10.3346/jkms.2018.33.e298
BACKGROUND: The renal function of individuals is one of the reasons for the variations in therapeutic response to various drugs. Patients with renal impairment are often exposed to drug toxicity,... -
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- Utility of Integrated Analysis of Pharmacogenomics and Pharmacometabolomics in Early Phase Clinical Trial: A Case Study of a New Molecular Entity
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Oh J, Yi S, Gu N, Shin D, Yu KS, Yoon SH, Cho JY, Jang IJ
- KMID: 2422812
- Genomics Inform.
- 2018 Sep;16(3):52-58.
- doi: 10.5808/GI.2018.16.3.52
In this report, we present a case study of how pharmacogenomics and pharmacometabolomics can be useful to characterize safety and pharmacokinetic profiles in early phase new drug development clinical trials.... -
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- Regional clinical pharmacology trials for Multi-Regional clinical trials
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Jang IJ
- KMID: 2420290
- Transl Clin Pharmacol.
- 2018 Sep;26(3):101-102.
- doi: 10.12793/tcp.2018.26.3.101
No abstract available. -
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- The Fas Signaling Pathway Is a Common Genetic Risk Factor for Severe Cutaneous Drug Adverse Reactions Across Diverse Drugs
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Park HW, Kim SH, Chang YS, Kim SH, Jee YK, Lee AY, Jang IJ, Park HS, Min KU
- KMID: 2418052
- Allergy Asthma Immunol Res.
- 2018 Sep;10(5):555-561.
- doi: 10.4168/aair.2018.10.5.555
PURPOSE: Human leukocyte antigen (HLA) has been recognized as the most important genetic risk factor for severe cutaneous adverse drug reactions (SCARs) caused by certain drugs. However, cumulated observations suggest... -
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- Retraction and Republication: A post hoc analysis of intra-subject coefficients of variation in pharmacokinetic measures to calculate optimal sample sizes for bioequivalence studies
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Chung I, Oh J, Lee S, Jang IJ, Lee Y, Chung JY
- KMID: 2420307
- Transl Clin Pharmacol.
- 2018 Mar;26(1):48-48.
- doi: 10.12793/tcp.2018.26.1.48
The retraction has been agreed upon due to critical typographical errors throughout the contents from accidents at the manuscript editing step. -
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- A post hoc analysis of intra-subject coefficients of variation in pharmacokinetic measures to calculate optimal sample sizes for bioequivalence studies
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Chung I, Oh J, Lee S, Jang IJ, Lee Y, Chung JY
- KMID: 2420301
- Transl Clin Pharmacol.
- 2018 Mar;26(1):6-9.
- doi: 10.12793/tcp.2018.26.1.6
Because bioequivalence studies are performed using a crossover design, information on the intra-subject coefficient of variation (intra-CV) for pharmacokinetic measures is needed when determining the sample size. However, calculated intra-CVs... -
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- A post hoc analysis of intra-subject coefficients of variation in pharmacokinetic measures to calculate optimal sample sizes for bioequivalence studies
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Chung I, Oh J, Lee S, Jang IJ, Lee Y, Chung JY
- KMID: 2406999
- Transl Clin Pharmacol.
- 2017 Dec;25(4):179-182.
- doi: 10.12793/tcp.2017.25.4.179
Because bioequivalence studies are performed using a crossover design, information on the intra-subject coefficient of variation (intra-CV) for pharmacokinetic measures is needed when determining the sample size. However, calculated intra-CVs... -
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- Pantoprazole Does Not Reduce the Antiplatelet Effect of Clopidogrel: A Randomized Controlled Trial in Korea
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Choi YJ, Kim N, Jang IJ, Cho JY, Nam RH, Park JH, Jo HJ, Yoon H, Shin CM, Park YS, Lee DH, Jung HC
- KMID: 2412230
- Gut Liver.
- 2017 Jul;11(4):504-511.
- doi: 10.5009/gnl16352
BACKGROUND/AIMS: Concerns that proton pump inhibitors (PPIs) diminish the efficacy of clopidogrel could hamper the appropriate prescription of PPIs. We evaluated the influence of pantoprazole on the antiplatelet effect of... -
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- Pharmacokinetic characteristics of fluticasone, salmeterol and tiotropium after concurrent inhalation
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Sunwoo J, Rhee SJ, Lee S, Lee SW, Jung J, Son H, Jang IJ
- KMID: 2386765
- Transl Clin Pharmacol.
- 2017 Jun;25(2):85-92.
- doi: 10.12793/tcp.2017.25.2.85
Chronic obstructive pulmonary disease (COPD) is a type of progressive, obstructive lung disease characterized by long-term poor airflow. The symptoms of COPD may be relieved and its progression delayed by... -
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- Effects of CYP2C19 Genetic Polymorphisms on PK/PD Responses of Omeprazole in Korean Healthy Volunteers
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Park S, Hyun YJ, Kim YR, Lee JH, Ryu S, Kim JM, Oh WY, Na HS, Lee JG, Seo DW, Hwang IY, Park Z, Jang IJ, Oh J, Choi SE
- KMID: 2375071
- J Korean Med Sci.
- 2017 May;32(5):729-736.
- doi: 10.3346/jkms.2017.32.5.729
The aim of this study was to examine the effects of CYP2C19*2 and *3 genetic polymorphisms on omeprazole pharmacokinetic (PK) and pharmacodynamic (PD) responses. Twenty-four healthy Korean volunteers were enrolled... -
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- Hydrochlorothiazide does not increase furosemide's effects in end-stage renal disease
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Huh W, Oh HY, Han JS, Jang IJ, Yim DS
- KMID: 2411416
- Transl Clin Pharmacol.
- 2017 Mar;25(1):28-33.
- doi: 10.12793/tcp.2017.25.1.28
Diuretic therapy for the treatment of edema in patients with end-stage renal disease (ESRD) is unsatisfactory, and a combination of thiazide and loop diuretics may produce better clinical effects. To... -
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- Targeted busulfan and fludarabine-based conditioning for bone marrow transplantation in chronic granulomatous disease
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Ju HY, Kang HJ, Hong CR, Lee JW, Kim H, Song SH, Yu KS, Jang IJ, Park JD, Park KD, Shin HY, Kim JG, Ahn HS
- KMID: 2362256
- Korean J Pediatr.
- 2016 Nov;59(Suppl 1):S57-S59.
- doi: 10.3345/kjp.2016.59.11.S57
Chronic granulomatous disease (CGD) is a primary immunodeficiency disease caused by impaired phagocytic function. Hematopoietic stem cell transplantation (HSCT) is a definitive cure for CGD; however, the use of HSCT... -
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- Comparison of R(+)-α-lipoic acid exposure after R(+)-α-lipoic acid 200 mg and 300 mg and thioctic acid 600 mg in healthy Korean male subjects
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Yoon J, Moon SJ, Lee KO, Yoon SH, Jang IJ, Yu KS, Lee S
- KMID: 2351800
- Transl Clin Pharmacol.
- 2016 Sep;24(3):137-142.
- doi: 10.12793/tcp.2016.24.3.137
Alpha-lipoic acid, a physiological form of thioctic acid, is a strong antioxidant that relieves diabetic neuropathic symptoms. R(+)-α-lipoic acid shows superior antioxidative effects to its racemate. We compared the pharmacokinetics... -
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