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Molecular Targeted Therapy in Modern Oncology: Imaging Assessment of Treatment Response and Toxicities

Krajewski , Braschi-Amirfarzan M, DiPiro PJ, Jagannathan JP, Shinagare

Oncology is a rapidly evolving field with a shift toward personalized cancer treatment. The use of therapies targeted to the molecular features of individual tumors and the tumor microenvironment has...
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Evolving Cancer Classification in the Era of Personalized Medicine: A Primer for Radiologists

O'Neill AC, Jagannathan JP, Ramaiya NH

Traditionally tumors were classified based on anatomic location but now specific genetic mutations in cancers are leading to treatment of tumors with molecular targeted therapies. This has led to a...
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Current Concepts in Non-Gastrointestinal Stromal Tumor Soft Tissue Sarcomas: A Primer for Radiologists

Baheti AD, Jagannathan JP, O'Neill A, Tirumani H, Tirumani S

Non-gastrointestinal stromal tumor (GIST) soft tissue sarcomas (STSs) are a heterogeneous group of neoplasms whose classification and management continues to evolve with better understanding of their biologic behavior. The 2013...
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Diffuse Large B-Cell Lymphoma in the Era of Precision Oncology: How Imaging Is Helpful

Shah HJ, Keraliya A, Jagannathan JP, Tirumani S, Lele VR, DiPiro PJ

Diffuse large B cell lymphoma (DLBCL) is the most common histological subtype of Non-Hodgkin's lymphoma. As treatments continues to evolve, so do imaging strategies, and positron emission tomography (PET) has...
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Update on Gastrointestinal Stromal Tumors for Radiologists

Tirumani S, Baheti AD, Tirumani H, O'Neill A, Jagannathan JP

The management of gastrointestinal stromal tumors (GISTs) has evolved significantly in the last two decades due to better understanding of their biologic behavior as well as development of molecular targeted...
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Fluid Retention Associated with Imatinib Treatment in Patients with Gastrointestinal Stromal Tumor: Quantitative Radiologic Assessment and Implications for Management

Kim KW, Shinagare , Krajewski , Pyo J, Tirumani S, Jagannathan JP, Ramaiya NH

OBJECTIVE: We aimed to describe radiologic signs and time-course of imatinib-associated fluid retention (FR) in patients with gastrointestinal stromal tumor (GIST), and its implications for management. MATERIALS AND METHODS: In this...
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