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IL-1beta Acts in Synergy with Endogenous IL-1beta in A375-S2 Human Melanoma Cell Apoptosis Through Mitochondrial Pathway

Wang C, Wang MW, Tashiro SI, Onodera S, Ikejima T

Interleukin-1beta (IL-1beta) is a pivotal proinflammatory cytokine. To investigate the mechanism of IL-1beta-induced cell death in human malignant melanoma A375-S2 cells, MTT assay, photomicroscopical observation, DNA agarose gel electrophoresis, radioimmunoassay...
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The Regulators of VEGF Expression in Mouse Ovaries

Shin SY, Lee HJ, Ko DS, Lee HC, Park WI

The objectives of this study were to explore whether ovarian vascular endothelial growth factor (VEGF) expression in mice can be regulated by IL-6 (interleukin-6), angiotensin II, FSH, and hCG; and...
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Cell-type specific regulation of thrombospondin-1 expression and its promoter activity by regulatory agents

Kim SA, Kang JH, Cho IH, Bae SW, Hong KJ

  • KMID: 938874
  • Exp Mol Med.
  • 2001 Sep;33(3):117-123.
Thrombospondin-1 (TSP-1), a multifunctional protein that is able to function as a negative regulator of solid tumor progression and angiogenesis, is normally present at a very low level but rapidly...
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Effect of Macrophage Migration Inhibitory Factor on Corneal Sensitivity after Laser In Situ Keratomileusis in Rabbit

Hyon JY, Hose S, Gongora C, Sinha D, O'Brien T

PURPOSE: To investigate the effect of macrophage migration inhibitory factor (MIF) on corneal sensitivity after laser in situ keratomileusis (LASIK) surgery. METHODS: New Zealand white rabbits were used in this study....
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