- NLRP3 Inflammasome and Host Protection against Bacterial Infection
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Kim JJ, Jo EK
- KMID: 1777675
- J Korean Med Sci.
- 2013 Oct;28(10):1415-1423.
- doi: 10.3346/jkms.2013.28.10.1415
The inflammasome is a multi-protein complex that induces maturation of inflammatory cytokines interleukin (IL)-1beta and IL-18 through activation of caspase-1. Several nucleotide binding oligomerization domain-like receptor family members, including NLRP3,... -
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- Interleukin-1beta promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways
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Lim JH, Um HJ, Park JW, Lee IK, Kwon TK
- KMID: 1009397
- Exp Mol Med.
- 2009 Oct;41(10):757-764.
- doi: 10.3858/emm.2009.41.10.082
Monocyte chemoattractant protein-1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this... -
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- Inflammatory Bowel Diseases and Inflammasome
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Kim JM
- KMID: 1043328
- Korean J Gastroenterol.
- 2011 Dec;58(6):300-310.
- doi: 10.4166/kjg.2011.58.6.300
Inflammatory bowel disease (IBD), the most important entities being ulcerative colitis and Crohn's disease, are chronic, relapsing and remitting inflammatory conditions that result from chronic dysregulation of the mucosal immune... -
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- SKI306X inhibition of glycosaminoglycan degradation in human cartilage involves down-regulation of cytokine-induced catabolic genes
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Choi CH, Kim TH, Sung YK, Choi CB, Na YI, Yoo H, Jun JB
- KMID: 1794630
- Korean J Intern Med.
- 2014 Sep;29(5):647-655.
- doi: 10.3904/kjim.2014.29.5.647
BACKGROUND/AIMS: SKI306X, a mixed extract of three herbs, Clematis mandshurica (CM), Prunella vulgaris (PV), and Trichosanthes kirilowii (TK), is chondroprotective in animal models of osteoarthritis (OA). The objectives of this... -
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- Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Augments Acute Lung Injury via Its Neutrophil Priming Effects
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Choi JC, Jung JW, Kwak HW, Song JH, Jeon EJ, Shin JW, Park IW, Choi BW, Kim JY
- KMID: 1713463
- J Korean Med Sci.
- 2008 Apr;23(2):288-295.
- doi: 10.3346/jkms.2008.23.2.288
Granulocyte macrophage-colony stimulating factor (GM-CSF) has immuno-stimulatory effects. We hypothesized that GM-CSF plays an important role both in lipopolysaccharide (LPS)- and hemorrhage-induced acute lung injury (ALI). We also postulated that... -
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- Anti-inflammatory Mechanism of Lactobacillus rhamnosus GG in Lipopolysaccharide-stimulated HT-29 Cell
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Lee SK, Yang KM, Cheon JH, Kim TI, Kim WH
- KMID: 1387336
- Korean J Gastroenterol.
- 2012 Aug;60(2):86-93.
- doi: 10.4166/kjg.2012.60.2.86
BACKGROUND/AIMS: Probiotics are live non-pathogenic organisms that belong to the resident microflora, and confer health benefits by multiple mechanisms. Lactobacillus rhamnosus GG (LGG) is one of the probiotic bacteria that... -
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- Cyclic AMP prolongs graft survival by suppressing apoptosis and inflammatory gene expression in acute cardiac allograft rejection
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Lee JY, Kim JH, Chae G, Lee BK, Ha KS, Kwon YG, Kim YM
- KMID: 946671
- Exp Mol Med.
- 2010 Jan;42(1):69-79.
- doi: 10.3858/emm.2010.42.1.008
This study was designed to investigate the effects of cAMP on immune regulation and apoptosis during acute rat cardiac allograft rejection. We found that the production of immune markers such... -
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- Gastroprotective Effects of PMK-S005 against Ethanol-Induced Acute Gastric Damage in Rats
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Choi YJ, Kim N, Lee JY, Nam RH, Seo JH, Lee S, Kim HJ, Choi YJ, Lee HS, Lee DH
- KMID: 2411960
- Gut Liver.
- 2016 May;10(3):348-355.
- doi: 10.5009/gnl14509
BACKGROUND/AIMS: This study aimed to examine the gastroprotective effects of PMK-S005, which is a synthetic S-allyl-L-cysteine (SAC; a sulfur-containing amino acid), against acute ethanol-induced gastric damage in rats. METHODS: Sprague-Dawley rats... -
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- Anti-Inflammatory Effect of Near-Infrared Irradiated Cell Culture Media
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Kim SG, Shin IH, Choi CH, Choe JY
- KMID: 1096928
- Korean J Lab Med.
- 2009 Aug;29(4):338-344.
- doi: 10.3343/kjlm.2009.29.4.338
BACKGROUND: Near-infrared light (NIR, 0.8-1.5 micrometer light) has been used in therapeutic devices for various injuries such as infected, ischemic and hypoxic wound. NIR-emitting technology has been developed recently in... -
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- A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-kappaB pathway in BV2 microglial cells
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Lee YH, Jeon SH, Kim SH, Kim C, Lee SJ, Koh D, Lim Y, Ha K, Shin SY
- KMID: 1383799
- Exp Mol Med.
- 2012 Jun;44(6):369-377.
Microglial cells are the resident innate immune cells that sense pathogens and tissue injury in the central nervous system (CNS). Microglial activation is critical for neuroinflammatory responses. The synthetic compound... -
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