- Increased Expression of Interleukin-12 in Lesional Skin of Atopic Dermatitis Patients with Psoriasiform Features on Histopathology: An Immunohistochemical Study
-
Lim HJ, Han MH, Lee EH, Eun DH, Kim JY, Lee WJ, Lee SJ, Kim DW, Park TI, Kim SH, Jang YH
- KMID: 2467198
- Ann Dermatol.
- 2020 Feb;32(1):31-37.
- doi: 10.5021/ad.2020.32.1.31
BACKGROUND: Based on clinical and genetic differences, atopic dermatitis (AD) and psoriasis have been classified in two different diseases, but recently, some authors regarded them as in one spectrum. The... -
- CITED
-
- Close
- SHARE
-
- Close
- IL-12 Enhances Immune Response by Modulation of Myeloid Derived Suppressor Cells in Tumor Microenvironment
-
Choi JN, Sun EG, Cho SH
- KMID: 2432253
- Chonnam Med J.
- 2019 Jan;55(1):31-39.
- doi: 10.4068/cmj.2019.55.1.31
Myeloid derived suppressor cells (MDSCs) are a heterogenous population of immature cells that play a critical role in tumor associated immune suppression. In tumor conditions, the population of MDSCs increases.... -
- CITED
-
- Close
- SHARE
-
- Close
- IL-12 and IL-23 Production in Toxoplasma gondii- or LPS-Treated Jurkat T Cells via PI3K and MAPK Signaling Pathways
-
Ismail HA, Kang BH, Kim JS, Lee JH, Choi IW, Cha GH, Yuk JM, Lee YH
- KMID: 2403712
- Korean J Parasitol.
- 2017 Dec;55(6):613-622.
- doi: 10.3347/kjp.2017.55.6.613
IL-12 and IL-23 are closely related in structure, and have been shown to play crucial roles in regulation of immune responses. However, little is known about the regulation of these... -
- CITED
-
- Close
- SHARE
-
- Close
- Moderate Exercise Enhances the Production of Interferon-γ and Interleukin-12 in Peripheral Blood Mononuclear Cells
-
Zamani A, Salehi I, Alahgholi-Hajibehzad M
- KMID: 2383357
- Immune Netw.
- 2017 Jun;17(3):186-191.
- doi: 10.4110/in.2017.17.3.186
The purpose of this study was to explore the effect of two months moderate exercise on levels of IFN-γ, IL-12, IL-6 and IL-4 in serum and supernatants of in vitro... -
- CITED
-
- Close
- SHARE
-
- Close
- Membrane-bound p35 Subunit of IL-12 on Tumor Cells is Functionally Equivalent to Membrane-bound Heterodimeric Single Chain IL-12 for Induction of Anti-tumor Immunity
-
Kim HJ, Park SM, Lee H, Kim YS
- KMID: 2355024
- Immune Netw.
- 2016 Oct;16(5):305-310.
- doi: 10.4110/in.2016.16.5.305
In this study, we compared two different tumor cell vaccines for their induction of anti-tumor immunity; one was a tumor cell clone expressing a membrane-bound form of IL-12 p35 subunit... -
- CITED
-
- Close
- SHARE
-
- Close
- Fermented antler extract enhances the viability and interleukin-12 production of spleen cells
-
Yang HY, Kim Y, Joo HG
- KMID: 2368765
- Korean J Vet Res.
- 2016 Sep;56(3):183-187.
- doi: 10.14405/kjvr.2016.56.3.183
The effects of antlers have long been known in traditional Asian medicine. However, few studies have investigated the effects of antlers on immunity. In this study, we investigated whether fermented... -
- CITED
-
- Close
- SHARE
-
- Close
- Cord blood IL-10, IL-12 in preterm newborns as predictors of respiratory distress syndrome and bronchopulmonary dysplasia
-
Park JY, Kim JY, Cho SJ, Kim YJ, Park HS, Ha EH, Park EA
- KMID: 2279243
- Korean J Pediatr.
- 2007 Mar;50(3):248-254.
- doi: 10.3345/kjp.2007.50.3.248
PURPOSE: Inflammation plays a major role in the pathogenesis of RDS and BPD in the immature lung. We investigated the possible role of IL-10 and IL-12 in the cord blood... -
- CITED
-
- Close
- SHARE
-
- Close
- IL-12 Production in Lipopolysaccharide- and Dermatophagoides pteronyssinus- Copulsed Monocyte-derived Dendritic Cells
-
- KMID: 2234385
- Korean J Asthma Allergy Clin Immunol.
- 2006 Sep;26(3):200-205.
BACKGROUND: Epidemiological studies have provided indirect evidence that exposure to less invasive microbials enhances the development of allergic diseases. Nonetheless, our understanding of the mechanisms that underlie this apparent symbiosis... -
- CITED
-
- Close
- SHARE
-
- Close
- The Role of Interleukin-12 in Dendritic Cells
-
- KMID: 2234384
- Korean J Asthma Allergy Clin Immunol.
- 2006 Sep;26(3):198-199.
No abstract available. -
- CITED
-
- Close
- SHARE
-
- Close
- TNF-alpha and IL-12 Secretion in Macrophages in Response to Spores of Bacillus anthracis Sterne
-
Baek JJ, Jung KH, Chai YG
- KMID: 2055021
- J Bacteriol Virol.
- 2006 Sep;36(3):141-150.
- doi: 10.4167/jbv.2006.36.3.141
Baerobic, spore forming, and rod-shaped bacterium. Anthrax spores are introduced into macrophage by phagocytosis and multiply after germination. The anthrax spores infected in macrophage produce lethal toxin eventually caused cell... -
- CITED
-
- Close
- SHARE
-
- Close
- The Change of Interleukin-12 and Transforming Growth Factor-beta1 Level in Manic Patients after Treatment
-
Choi HS, Kim YK
- KMID: 1511931
- Korean J Biol Psychiatry.
- 2006 Feb;13(1):32-37.
BACKGROUND: Several studies have suggested that alterations of cytokine level could be related to the pathophysiology of bipolar disorder. In this study, we measured plasma level of Interleukin-12(IL-12), a pro-inflammatory... -
- CITED
-
- Close
- SHARE
-
- Close
- Changes of Interleukin-12 and Transforming Growth Factor Beta 1 before and after Antipsychotic Treatments in Schizophrenic Patients
-
Kim SJ, Lee BH, Kim YK
- KMID: 2299956
- Korean J Biol Psychiatry.
- 2005 Nov;12(2):143-150.
BACKGROUND: Several reports have suggested that cytokine alterations could be related to the pathophysiology of schizophrenia. In this study, we measured plasma level of interleukin-12(IL-12), a pro-inflammatory T helper 1(Th1)... -
- CITED
-
- Close
- SHARE
-
- Close
- Mycobacteria-induced Interleukin-12 Expression by Human Monocyte-derived Macrophages Is Negatively Regulated by Phosphatidylinositol 3-kinase and ERK 1/2 Pathways
-
Yang CS, Lee JS, Song CH, Jung SB, Lee KS, Shin AR, Kim HJ, Park JK, Paik TH, Jo EK
- KMID: 1574166
- J Bacteriol Virol.
- 2005 Sep;35(3):239-248.
Both interleukin (IL)-12, an important cytokine skewing the immune response towards a Th1 cytokine profiles, and tumor necrosis factor (TNF)-alpha, are thought to be critical factors in defenses against mycobacteria.... -
- CITED
-
- Close
- SHARE
-
- Close
- Induction of TNF-alpha, IL-12, IL-10, MCP-1 and IL-8 in Human Peripheral Blood Monocytes in Response to the Cell Wall-Associated Triton X-100 Soluble Protein (TSP) Antigens of Mycobacterium tuberculosis
-
Lee JS, Paik TH, Yoo YC, Lee J, Song CH, Jo EK, Kim HJ, Park JK
- KMID: 1574165
- J Bacteriol Virol.
- 2005 Sep;35(3):227-238.
Mycobacterium tuberculosis is a potent inducer of cytokine production by mononuclear phagocytes, which are an important cellular component in the first line immune defence. In this study, the cell wall-associated... -
- CITED
-
- Close
- SHARE
-
- Close
- IL-18Ralpha Mediated GATA-3 Induction by Th2 Cells: IL-12 Supports IL-18Ralpha Expression in Th2 Cells
-
Joo IS, Sun MJ, Kim DY, Lee SJ, Ha YM, Cho JJ, Park CS, Ahn HJ
- KMID: 2150585
- Immune Netw.
- 2005 Mar;5(1):16-22.
- doi: 10.4110/in.2005.5.1.16
BACKGROUND: IL-18 was originally cloned as a IFN-gamma inducing factor in primed T cells. In synergy with IL-12, IL-18 has been shown to induce strikingly high levels of IFN-gamma production... -
- CITED
-
- Close
- SHARE
-
- Close
- Immunization with Adenoviral Vectors Carrying Recombinant IL-12 and E7 Enhanced the Antitumor Immunity against Human Papillomavirus 16-associated Tumor
-
Park EK, Kim YW, Lee JM, NamKoong S, Kim DG, Chun HJ, Han BD, Bae SM, Jin HS, Sin JI, Ahn WS
- KMID: 1743357
- Cancer Res Treat.
- 2005 Feb;37(1):63-70.
PURPOSE: Human papillomavirus (HPV) infection has a significant role in cervical carcinogenesis, and HPV oncoprotein E7 plays an important part in the formation and maintenance of cervical cancer. Interleukin-12 (IL-12)... -
- CITED
-
- Close
- SHARE
-
- Close
- The Effectiveness of IL-12 Administration and Fusion on Tumor Antigen Sensitization Methods for Dendritic Cells Derived from Patients with Myelogenous Leukemia
-
Kim KW, Park SY, Hong YS
- KMID: 2054242
- Immune Netw.
- 2004 Mar;4(1):38-43.
- doi: 10.4110/in.2004.4.1.38
BACKGROUND: Immunotherapy using dendritic cells (DC) loaded with tumor antigens may represent a potentially effective method for inducing antitumor immunity. We evaluated the effectiveness of DC-based antitumor immune response in... -
- CITED
-
- Close
- SHARE
-
- Close
- Induction of Anti-tumor Immunity by Vaccination with E7 of HPV16 and IL-12
-
Park EK, Jin TY, Yoon CG, Choi MN, Huh SW, Bae SM, Kim YW, Yoon JH, Ahn WS, Kim CK, Lee JM, Namkoong S, Kang KD
- KMID: 1925286
- Korean J Obstet Gynecol.
- 2003 Dec;46(12):2373-2379.
OBJECTIVE: Interleukin-12 is well known to induce cellular immune response materials and suppress the tumor growth. HPV infection has significant roles in cervical carcinogenesis, and HPV oncoprotein E6 and E7... -
- CITED
-
- Close
- SHARE
-
- Close
- IL-12 Production and Subsequent Natural Killer Cell Activation by Necrotic Tumor Cell-loaded Dendritic Cells in Therapeutic Vaccinations
-
Kim A, Kim KD, Choi SC, Jeong MJ, Lee HG, Choe YK, Paik SG, Lim JS
- KMID: 1615310
- Immune Netw.
- 2003 Sep;3(3):188-200.
- doi: 10.4110/in.2003.3.3.188
BACKGROUND: Immunization of dendritic cells (DCs) pulsed with tumor antigen can activate tumor-specific cytotoxic T lymphocytes (CTL) that are responsible for protection and regression. In this study, we examined whether... -
- CITED
-
- Close
- SHARE
-
- Close
- The Modulation of IL-12 by Phosphodiesterase IV Inhibitor and Subsequent Changes of Th-1, Th-2 Cytokines in Human Endometrial Tissue
-
Park WI, Kim EK, Ko DS, Hong SY, Na JY, Shin JH, Kim DW
- KMID: 2272121
- Korean J Obstet Gynecol.
- 2003 Aug;46(8):1500-1509.
OBJECTIVE: To assess the capability of phosphodiesterase type IV inhibitor (rolipram) to suppress IL-12 in human decidua and the subsequent changes of Th-2 cytokine (IL-10) and Th-1 cytokine (TNF-alpha). METHODS: Decidual... -
- CITED
-
- Close
- SHARE
-
- Close
