- Effects of Calcium Channel Blockers and Insulin on the Platelet Function in Patients with Diabetes Mellitus
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Lee YS, Hahm KS, Lee SY
- KMID: 693024
- Yonsei Med J.
- 1986 Jun;27(2):132-137.
- doi: 10.3349/ymj.1986.27.2.132
Platelet aggregability was compared between platelets isolated from normal subjects and patients with diabetes mellitus in order to evaluate the effects of calcium channel blockers and insulin on the platelet... -
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- Histochemical and Cytogenetical Effects of Insulin on Mouse Liver in vivo and in vitro
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Hahn SS, Kim DS
- KMID: 687761
- Yonsei Med J.
- 1978 Dec;19(2):48-55.
- doi: 10.3349/ymj.1978.19.2.48
Histochemically detectable changes in the liver of the mouse after subcutaneous injection of a single sublethal does of insulin and the effect of insulin on mitotic rate and chromosome changes... -
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- Modulation of the caveolin-3 and Akt status in caveolae by insulin resistance in H9c2 cardiomyoblasts
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Ha H, Pak Y
- KMID: 1056228
- Exp Mol Med.
- 2005 Jun;37(3):169-178.
We investigated glucose uptake and the translocation of Akt and caveolin-3 in response to insulin in H9c2 cardiomyoblasts exposed to an experimental insulin resistance condition of 100 nM insulin in... -
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- The biologic role of ganglioside in neuronal differentiation: effects of GM1 ganglioside on human neuroblastoma SH-SY5Y cells
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Lee MC, Lee WS, Park CS, Juhng SW
- KMID: 1422174
- J Korean Med Sci.
- 1994 Apr;9(2):179-187.
- doi: 10.3346/jkms.1994.9.2.179
Human neuroblastoma SH-SY5Y cell is a cloned cell line which has many attractive features for the study of neuronal proliferation and neurite outgrowth, because it has receptors for insulin, IGF-I... -
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- Amelioration of diabetic microalbuminuria and lipid peroxidation by captopril
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Ha H, Kim KH
- KMID: 1120232
- Yonsei Med J.
- 1992 Sep;33(3):217-223.
- doi: 10.3349/ymj.1992.33.3.217
Administration of captopril, a scavenger of oxygen derived radicals as well as an inhibitor of angiotensin converting enzyme, has been an efficient way of treating diabetic proteinuria. In the present... -
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- The regulatory mechanism of phosphatidylinositol 3-kinase by insulin in 3T3 L1 fibroblasts: phosphorylation-independent activation of phosphatidylinositol 3-kinase
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Kang IS, Choi SL, Kim SS, Kim SJ, Ha JH, Oh SM, Kim SS
- KMID: 755019
- Exp Mol Med.
- 1998 Dec;30(4):263-269.
Phosphatidylinositol (PI) 3-kinase plays an important role in transducing the signals of various growth factor receptors. However, the regulatory mechanism of PI3-kinase activity by these growth factor receptors is not... -
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- Effect of Inslulin Administration on the Physical Performance of Rats and Mice
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Lee WK, Park HK, Hong SI, Kang DH
- KMID: 2439769
- Yonsei Med J.
- 1973 Dec;14(1):10-17.
The correlation between muscle glycogen content and physical performance in mice was evaluated by investigating whether an increase in glycogen content in skeletal muscle with insulin administration can improve the... -
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- Rapid increase of cytosolic content of acetyl-CoA carboxylase isoforms in H9c2 cells by short-term treatment with insulin and okadaic acid
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Park CE, Ko SM, Kim JM, Yoon MY, Kim JY, Kang IS, Kim SS, Ha JH
- KMID: 754991
- Exp Mol Med.
- 1998 Jun;30(2):73-79.
Mammalian acetyl-CoA carboxylase (ACC) is present in two isoforms, alpha and beta, both of which catalyze formation of malonyl-CoA by fixing CO2 into acetyl-CoA. ACC-alpha is highly expressed in lipogenic tissues whereas... -
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- Cilostazol inhibits insulin-stimulated expression of sterol regulatory binding protein-1c via inhibition of LXR and Sp1
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Jung YA, Kim HK, Bae KH, Seo HY, Kim HS, Jang BK, Jung GS, Lee IK, Kim MK, Park KG
- KMID: 2155338
- Exp Mol Med.
- 2014 Jan;46(1):e73.
- doi: 10.1038/emm.2013.143
Hepatic steatosis is common in obese individuals with hyperinsulinemia and is an important hepatic manifestation of metabolic syndrome. Sterol regulatory binding protein-1c (SREBP-1c) is a master regulator of lipogenic gene... -
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- Chronic ethanol feeding impairs AMPK and MEF2 expression and is associated with GLUT4 decrease in rat myocardium
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Chen L, Wang F, Sun X, Zhou J, Gao L, Jiao Y, Hou X, Qin C, Zhao J
- KMID: 946653
- Exp Mol Med.
- 2010 Mar;42(3):205-215.
- doi: 10.3858/emm.2010.42.3.021
Chronic and heavy alcohol consumption is one of the causes of heart diseases. However, the effects of ethanol on insulin sensitivity in myocardium has been unclear. To investigate the effects... -
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- Hepatic STAMP2 decreases hepatitis B virus X protein-associated metabolic deregulation
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Kim HY, Cho HK, Yoo SK, Cheong J
- KMID: 1506226
- Exp Mol Med.
- 2012 Oct;44(10):622-632.
Six transmembrane protein of prostate 2 (STAMP2) plays a key role in linking inflammatory and diet-derived signals to systemic metabolism. STAMP2 is induced by nutrients/feeding as well as by cytokines... -
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- Differentiation of human labia minora dermis-derived fibroblasts into insulin-producing cells
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Kim B, Yoon BS, Moon JH, Kim J, Jun EK, Lee JH, Kim JS, Baik CS, Kim A, Whang KY, You S
- KMID: 1120139
- Exp Mol Med.
- 2012 Jan;44(1):26-35.
- doi: 10.3858/emm.2012.44.1.002
Recent evidence has suggested that human skin fibroblasts may represent a novel source of therapeutic stem cells. In this study, we report a 3-stage method to induce the differentiation of... -
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- Role of protease inhibitors and acylation stimulating protein in the adipogenesis in 3T3-L1 cells
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Soliman MM, El-Senosi , Salem MM, Hamid OM, Kazuhiro K
- KMID: 1726918
- J Vet Sci.
- 2009 Sep;10(3):197-201.
- doi: 10.4142/jvs.2009.10.3.197
Treatment of AIDS (HIV) and hepatitis C virus needs protease inhibitors (PI) to prevent viral replication. Uses of PI in therapy are usually associated with a decrease in body weight... -
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- Insulin-dependent suppression of cholesterol 7alpha-hydroxlase is a possible link between glucose and cholesterol metabolisms
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Park WH, Pak YK
- KMID: 1123369
- Exp Mol Med.
- 2011 Oct;43(10):571-579.
- doi: 10.3858/emm.2011.43.10.064
Cholesterol 7alpha-hydroxylase (CYP7A1) regulates the balance between cholesterol supply and metabolism by catalyzing the rate-limiting step of bile acid biosynthesis. The transcriptional activity of CYP7A1 is tightly controlled by various... -
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- Expression and Regulation of Osteoprotegerin in Adipose Tissue
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An JJ, Han DH, Kim DM, Kim SH, Rhee Y, Lee EJ, Lim SK
- KMID: 1122612
- Yonsei Med J.
- 2007 Oct;48(5):765-772.
- doi: 10.3349/ymj.2007.48.5.765
PURPOSE: Osteoprotegerin (OPG), a potent inhibitor of osteoclastic bone resorption, has a variety of biological functions that include anti-inflammatory effects. Adipocytes and osteoblasts share a common origin, and the... -
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- Increased expression of Galphaq protein in the heart of streptozotocin-induced diabetic rats
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Yang JM, Cho CH, Kong KA, Jang IS, Kim HW, Juhnn YS
- KMID: 1029924
- Exp Mol Med.
- 1999 Dec;31(4):179-184.
Heart disease is one of the major cause of death in diabetic patients, but the thogenesis of diabetic cardio-myopathy remains unclear. In this experiment, to sess the significance... -
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- Dysferlin in a hyperCKaemic patient with caveolin 3 mutation and in C2C12 cells after p38 MAP kinase inhibition
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Capanni C, Sabatelli , Mattioli E, Ognibene A, Columbaro , Lattanzi G, Merlini L, Minetti C, Maraldi NM, Squarzoni
- KMID: 1119336
- Exp Mol Med.
- 2003 Dec;35(6):538-544.
Dysferlin is a plasma membrane protein of skeletal muscle whose deficiency causes Miyoshi myopathy, limb girdle muscular dystrophy 2B and distal anterior compartment myopathy. Recent studies have reported that dysferlin... -
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