- Back to the T Cell: Basic and Clinical Application
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Jung YW, Park SH, Jun CD
- KMID: 2544656
- Immune Netw.
- 2023 Feb;23(1):e1.
- doi: 10.4110/in.2023.23.e1
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- Molecular Mechanisms of T Helper Cell Differentiation and Functional Specialization
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Lee GR
- KMID: 2544659
- Immune Netw.
- 2023 Feb;23(1):e4.
- doi: 10.4110/in.2023.23.e4
Th cells, which orchestrate immune responses to various pathogens, differentiate from naïve CD4 T cells into several subsets that stimulate and regulate immune responses against various types of pathogens, as... -
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- Roles of Virtual Memory T Cells in Diseases
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Seok J, Cho SD, Seo SJ, Park SH
- KMID: 2544655
- Immune Netw.
- 2023 Feb;23(1):e11.
- doi: 10.4110/in.2023.23.e11
Memory T cells that mediate fast and effective protection against reinfections are usually generated upon recognition on foreign Ags. However, a “memory-like” T-cell population, termed virtual memory T (T VM... -
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- Microbial Components and Effector Molecules in T Helper Cell Differentiation and Function
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Lee C, Lee H, Park JC, Im SH
- KMID: 2544662
- Immune Netw.
- 2023 Feb;23(1):e7.
- doi: 10.4110/in.2023.23.e7
The mammalian intestines harbor trillions of commensal microorganisms composed of thousands of species that are collectively called gut microbiota. Among the microbiota, bacteria are the predominant microorganism, with viruses, protozoa,... -
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- Gut Microbial Metabolites on Host Immune Responses in Health and Disease
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Yoon JH, Do JS, Velankanni P, Lee CG, Kwon HK
- KMID: 2544661
- Immune Netw.
- 2023 Feb;23(1):e6.
- doi: 10.4110/in.2023.23.e6
Intestinal microorganisms interact with various immune cells and are involved in gut homeostasis and immune regulation. Although many studies have discussed the roles of the microorganisms themselves, interest in the... -
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- Shaping Heterogeneity of Naive CD8+ T Cell Pools
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Lee SW, Lee GW, Kim HO, Cho JH
- KMID: 2544657
- Immune Netw.
- 2023 Feb;23(1):e2.
- doi: 10.4110/in.2023.23.e2
Immune diversification helps protect the host against a myriad of pathogens. CD8+ T cells are essential adaptive immune cells that inhibit the spread of pathogens by inducing apoptosis in infected... -
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- The Function of Memory CD8+ T Cells in Immunotherapy for Human Diseases
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Choi H, Kim Y, Jung YW
- KMID: 2544654
- Immune Netw.
- 2023 Feb;23(1):e10.
- doi: 10.4110/in.2023.23.e10
Memory T (Tm) cells protect against Ags that they have previously contacted with a fast and robust response. Therefore, developing long-lived Tm cells is a prime goal for many vaccines... -
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- Human CD8+ T-Cell Populations That Express Natural Killer Receptors
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Koh JY, Kim DU, Moon BH, Shin EC
- KMID: 2544663
- Immune Netw.
- 2023 Feb;23(1):e8.
- doi: 10.4110/in.2023.23.e8
CD8+ T cells are activated by TCRs that recognize specific cognate Ags, while NK-cell activation is regulated by a balance between signals from germline-encoded activating and inhibitory NK receptors. Through... -
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- Metabolic Challenges in Anticancer CD8 T Cell Functions
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Amitrano AM, Kim M
- KMID: 2544664
- Immune Netw.
- 2023 Feb;23(1):e9.
- doi: 10.4110/in.2023.23.e9
Cancer immunotherapies continue to face numerous obstacles in the successful treatment of solid malignancies. While immunotherapy has emerged as an extremely effective treatment option for hematologic malignancies, it is largely... -
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- T Cell Microvilli: Finger-Shaped External Structures Linked to the Fate of T Cells
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Kim HR, Park JS, Soh WC, Kim NY, Moon HY, Lee JS, Jun CD
- KMID: 2544658
- Immune Netw.
- 2023 Feb;23(1):e3.
- doi: 10.4110/in.2023.23.e3
Microvilli are outer membrane organelles that contain cross-linked filamentous actin. Unlike well-characterized epithelial microvilli, T-cell microvilli are dynamic similar to those of filopodia, which grow and shrink intermittently via the alternate... -
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- Transcriptional and Epigenetic Regulation of Context-Dependent Plasticity in T-Helper Lineages
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Friedman MJ, Lee H, Lee JY, Oh S
- KMID: 2544660
- Immune Netw.
- 2023 Feb;23(1):e5.
- doi: 10.4110/in.2023.23.e5
Th cell lineage determination and functional specialization are tightly linked to the activation of lineage-determining transcription factors (TFs) that bind cis-regulatory elements. These lineage-determining TFs act in concert with multiple... -
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