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Enhancement of Allergen-induced Airway Inflammation by NOX2 Deficiency

Won HY, Jang EJ, Min HJ, Hwang ES

BACKGROUND: NADPH oxidase (NOX) modulates cell proliferation, differentiation and immune response through generation of reactive oxygen species. Particularly, NOX2 is recently reported to be important for regulating Treg cell differentiation...
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Enhanced Induction of T Cell Immunity Using Dendritic Cells Pulsed with HIV Tat and HCMV-pp65 Fusion Protein In Vitro

Park JS, Park SY, Cho HI, Sohn HJ, Kim TG

BACKGROUND: Cytotoxic T lymphocytes (CTLs) appear to play an important role in the control and prevention of human cytomegalovirus (HCMV) infection. The pp65 antigen is a structural protein, which has...
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Formulation and Characterization of Antigen-loaded PLGA Nanoparticles for Efficient Cross-priming of the Antigen

Lee YR, Lee YH, Im SA, Kim K, Lee CK

BACKGROUND: Nanoparticles (NPs) prepared from biodegradable polymers, such as poly (D,L-lactic acid-co-glycolic acid) (PLGA), have been studied as vehicles for the delivery of antigens to phagocytes. This paper describes the...
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MicroRNAs in Human Diseases: From Cancer to Cardiovascular Disease

Ha TY

The great discovery of microRNAs (miRNAs) has revolutionized current cell biology and medical science. miRNAs are small conserved non-coding RNA molecules that post-transcriptionally regulate gene expression by targeting the 3'...
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Ribosomal Protein L19 and L22 Modulate TLR3 Signaling

Yang EJ, Seo JW, Choi IH

BACKGROUND: Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA) and induces inflammation. In this study we attempted to ascertain if there are endogenous host molecules controlling the production of cytokines...
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Identification of CM1 as a Pathogenic Factor in Inflammatory Diseases and Cancer

Bae S, Kim H, Yu YS, Lee NE, Kong JM, Kim HR, Hwang YI, Song YW, Kang JS, Lee WJ

BACKGROUND: CM1 (centrocyte/-blast marker 1) was defined by a mAb against concanavalin A (Con A) activated PBMC. It is expressed in germinal center of human tonsil and on the surface...
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