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Evaluation of the Involvement of Coiled-coil αα-helical Rod Protein 1 (CCHCR1) in Imiquimod-induced Psoriasis Models

Ikeda Y, Tsutihashi H, Wada A, Koyama S, Yoshihara N, Ikeda S

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A Molecular Mucosal Adjuvant To Enhance Immunity Against Pneumococcal Infection In The Elderly

Fukuyama Y, Ikeda Y, Ohori J, Sugita G, Aso K, Fujihashi , Briles DE, McGhee JR, Fujihashi

Streptococcus pneumoniae (the pneumococcus) causes a major upper respiratory tract infection often leading to severe illness and death in the elderly. Thus, it is important to induce safe and effective...
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Evaluation of Circulating Tumor DNA in Patients with Ovarian Cancer Harboring Somatic PIK3CA or KRAS Mutations

Ogasawara A, Hihara T, Shintani D, Yabuno A, Ikeda Y, Tai K, Fujiwara K, Watanabe K, Hasegawa K

Purpose Circulating tumor DNA (ctDNA) is an attractive source for liquid biopsy to understand molecular phenotypes of a tumor non-invasively, which is also expected to be both a diagnostic and prognostic...
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Feline Interstitial Cystitis Enhances Mucosa-Dependent Contractile Responses to Serotonin

Ikeda Y, Wolf-Johnston A, Roppolo JR, Buffington CAT, Birder L

PURPOSE: To determine whether responses to serotonin are altered in bladder strips from cats diagnosed with a naturally occurring form of bladder pain syndrome/interstitial cystitis termed feline interstitial cystitis (FIC). METHODS:...
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Reduction of oocyte lipid droplets and meiotic failure due to biotin deficiency was not rescued by restoring the biotin nutritional status

Tsuji A, Ikeda Y, Murakami M, Kitagishi Y, Matsuda S

BACKGROUND/OBJECTIVES: Oocyte lipid droplets play a crucial role in meiosis and embryo development. Biotin is associated with fatty acid synthesis and is the coenzyme for acetyl-CoA carboxylase (ACC). The effects...
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The Short-term Outcomes of Physiotherapy for Patients with Acetabular Labral Tears: An Analysis according to Severity of Injury in Magnetic Resonance Imaging

Kawai M, Tateda K, Ikeda Y, Kosukegawa I, Nagoya S, Katayose M

Purpose: The aim of this study was to evaluate the short-term outcome of physiotherapy in patients with acetabular labral tears and to assess the effectiveness of physiotherapy according to the...
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Survival benefits of retroperitoneal lymphadenectomy for optimally-resected advanced ovarian high-grade serous carcinoma: a multi-institutional retrospective study

Ikeda Y, Yoshihara M, Tamauchi S, Yokoi A, Yoshikawa N, Kajiyama H

Objective The survival benefits of retroperitoneal lymphadenectomy (RLNA) for epithelial ovarian cancer (EOC) remain controversial because clinical behaviors differ among subtypes. The purpose of the present study was to clarify whether...
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Association Between Eating Behavior, Frequency of Meals, and Functional Dyspepsia in Young Japanese Population

Yamamoto Y, Furukawa S, Watanabe J, Kato A, Kusumoto K, Miyake T, Takeshita E, Ikeda Y, Yamamoto N, Kohara K, Saheki S, Saeki Y, Hiasa Y

  • KMID: 2531187
  • J Neurogastroenterol Motil.
  • 2022 Jul;28(3):418-423.
  • doi: 10.5056/jnm21146
Background/Aims Functional dyspepsia (FD) may be a common digestive disease worldwide and reduces the quality of life of patients. However, only a few studies have investigated the association between eating behavior...
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Association Between Body Mass Index and Functional Dyspepsia in Young Japanese People

Yamamoto Y, Furukawa S, Watanabe J, Kato A, Kusumoto K, Takeshita E, Ikeda Y, Yamamoto N, Kohara K, Saeki Y, Hiasa Y

  • KMID: 2528042
  • J Neurogastroenterol Motil.
  • 2022 Apr;28(2):276-282.
  • doi: 10.5056/jnm21076
Background/Aims Evidence regarding the association between body mass index (BMI) and functional dyspepsia (FD) in the Asian population is limited. Further, no study has evaluated this issue in young people in Asian...
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High expression of maternal embryonic leucine-zipper kinase (MELK) impacts clinical outcomes in patients with ovarian cancer and its inhibition suppresses ovarian cancer cells growth ex vivo

Ikeda Y, Sato S, Yabuno A, Shintani D, Ogasawara A, Miwa M, Zewde M, Miyamoto T, Fujiwara K, Nakamura Y, Hasegawa K

Objective: Maternal embryonic leucine zipper kinase (MELK) is receiving an attention as a therapeutic target in various types of cancers. In this study, we aimed to evaluate the prognostic significance...
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Clinical utility of CA-125 in the management of uterine carcinosarcoma

Matsuo K, Ross MS, Yunokawa M, Johnson MS, Machida H, Omatsu K, Klobocista MM, Im DD, Satoh S, Baba T, Ikeda Y, Bush SH, Hasegawa K, Blake EA, Takekuma M, Shida M, Nishimura , Adachi S, Pejovic T, Takeuchi S, Yokoyama T, Ueda Y, Iwasaki K, Miyake TM, Yanai S, Nagano T, Takano T, Shahzad MM, Ueland FR, Kelley JL, Roman LD

No abstract available.
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The albumin to globulin ratio is associated with clinical outcome in Japanese patients with ulcerative colitis

Yagi S, Furukawa S, Shiraishi K, Miyake T, Tange K, Hashimoto Y, Kitahata S, Kawamura T, Ninomiya T, Mori K, Suzuki S, Shibata N, Murakami H, Ohashi K, Hasebe A, Tomida H, Yamamoto Y, Takeshita E, Ikeda Y, Hiasa Y

Purpose: The albumin-to-globulin ratio (AGR) is a recognized chronic inflammation marker. No evidence regarding the relationship between AGR level and ulcerative colitis (UC) exists. The aim of this study was...
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Practice patterns of adjuvant therapy for intermediate/high recurrence risk cervical cancer patients in Japan

Ikeda Y, Furusawa A, Kitagawa R, Tokinaga A, Ito F, Ukita M, Nomura H, Yamagami W, Tanabe H, Mikami M, Takeshima , Yaegashi N

OBJECTIVE: Although radiation therapy (RT) and concurrent chemoradiotherapy (CCRT) are the global standards for adjuvant therapy treatment in cervical cancer, many Japanese institutions choose chemotherapy (CT) because of the low...
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