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Targeted temperature management for ischemic stroke

Hong JM

Therapeutic hypothermia (TH) or targeted temperature management is an intentional cooling or temperature control technique using a thermostatic equipment (i.e., surface, endovascular, and focal devices) for specific therapeutic purposes. Given...
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Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia

Jeon GW, Sheldon RA, Ferriero D

BACKGROUND: Sixty percent of infants with severe neonatal hypoxic-ischemic encephalopathy die, while most survivors have permanent disabilities. Treatment for neonatal hypoxic-ischemic encephalopathy is limited to therapeutic hypothermia, but it does...
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Management of post-cardiac arrest syndrome

Kang Y

Post-cardiac arrest syndrome is a complex and critical issue in resuscitated patients undergone cardiac arrest. Ischemic-reperfusion injury occurs in multiple organs due to the return of spontaneous circulation. Bundle of...
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Primary neurocritical care involving therapeutic hypothermia for acute ischemic stroke patients with malignant infarct cores

Lee SJ, Lee KS, Lee JS, Choi MH, Lee SE, Hong JM

BACKGROUND: Acute ischemic stroke patients with malignant infarct cores were primarily treated with neurocritical care based on reperfusion and hypothermia. We evaluated the predictors for malignant progression and functional outcomes. METHODS:...
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Targeted temperature management is related to improved clinical outcome of out-of-hospital cardiac arrest with non-shockable initial rhythm

Kim SG, Cha WC, Sim MS, Hwang SY, Shin TG, Park JH, Yoon H, Jo IJ, Choi JH

OBJECTIVE: The benefits of targeted temperature management (TTM) for resuscitated out of hospital cardiac arrest (OHCA) with an initial non-shockable rhythm are still unclear. This study examined whether TTM reduces...
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Assessment of serum biomarkers and coagulation/fibrinolysis markers for prediction of neurological outcomes of out of cardiac arrest patients treated with therapeutic hypothermia

Park JH, Wee JH, Choi SP, Oh JH, Cheol S

OBJECTIVE: Despite increased survival in patients with cardiac arrest, it remains difficult to determine patient prognosis at the early stage. This study evaluated the prognosis of cardiac arrest patients using...
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Predictors of Neurodevelopmental Outcomes in Newborns Undergoing Hypothermia Therapy

Chun MK, Sung HJ, Park JH, Lim GY, Kim SY

PURPOSE: This study aimed to identify the early predictors of neurodevelopmental outcomes in infants undergoing therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy. METHODS: The medical records of 24 neonates who underwent...
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Human Neural Stem Cells: Translational Research for Neonatal Hypoxic-Ischemic Brain Injury

Shin JE, Han J, Lim JH, Eun HS, Park KI

Neonatal hypoxic-ischemic (HI) brain injury is a major cause of neonatal mortality and long-term neurodevelopmental disabilities. Although promising neuroprotective interventions have been studied, the current management of HI brain injury...
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Comparison between Gel Pad Cooling Device and Water Blanket during Target Temperature Management in Cardiac Arrest Patients

Jung YS, Kim KS, Suh GJ, Cho JH

BACKGROUND: Target temperature management (TTM) improves neurological outcomes for comatose survivors of out-of-hospital cardiac arrest. We compared the efficacy and safety of a gel pad cooling device (GP) and a...
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Nursing Frequency, Nursing Time, and Nursing Intervention Priorities depending on Neonatal Therapeutic Hypothermia Methods

Kim DY, Jo KA, Yi BR, Park HR

PURPOSE: This study compared nursing frequency, nursing time, and nursing intervention priorities depending on the method of neonatal induced hypothermia. METHODS: We observed 15 neonatal subjects receiving therapeutic hypothermia for 3...
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Hemoglobin concentration is associated with neurologic outcome after cardiac arrest in patients treated with targeted temperature management

Kim D, Kim SH, Park KN, Oh SH, Kim YM, Youn CS

OBJECTIVE: The objective of this study was to test the hypothesis that hemoglobin concentration after return of spontaneous circulation (ROSC) is associated with neurologic outcome after cardiac arrest in patients...
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Complete Recovery of Perfusion Abnormalities in a Cardiac Arrest Patient Treated with Hypothermia: Results of Cerebral Perfusion MR Imaging

Kim MJ, Park YW, Lim SM

Therapeutic hypothermia in cardiac arrest patients is associated with favorable outcomes mediated via neuroprotective mechanisms. We report a rare case of a 32-year-old male who demonstrated complete recovery of signal...
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Therapeutic Hypothermia for Hypoxic-Ischemic Encephalopathy in Newborn Infants

Sung IK

Neonatal hypoxic-ischemic encephalopathy (HIE) is an ongoing process, which may persist for weeks to years after an acute asphyxial insult, causing delayed programmed cell death. The typical clinical signs and...
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Extracorporeal Cardiopulmonary Resuscitation with Therapeutic Hypothermia for Prolonged Refractory In-hospital Cardiac Arrest

Kim YS, Lee YJ, Won KB, Kim JW, Lee SC, Park CR, Jung JP, Choi W

BACKGROUND AND OBJECTIVES: We identified the impact of extracorporeal cardiopulmonary resuscitation (ECPR) followed by therapeutic hypothermia on survival and neurologic outcome in patients with prolonged refractory in-hospital cardiac arrest (IHCA). METHODS:...
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Feasibility and Safety of Mild Therapeutic Hypothermia in Poor-Grade Subarachnoid Hemorrhage: Prospective Pilot Study

Choi W, Kwon SC, Lee WJ, Weon YC, Choi B, Lee H, Park ES, Ahn R

Therapeutic hypothermia (TH) improves the neurological outcome in patients after cardiac arrest and neonatal hypoxic brain injury. We studied the safety and feasibility of mild TH in patients with poor-grade...
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Factors Influencing the Quality of Standardized Treatment for Patients with Post-Cardiac Arrest Syndrome

Lu J, Liu L, Zhu J, Guo X

BACKGROUND AND OBJECTIVES: For the present study, we investigated the factors that influence the quality of standardized treatment for patients with post-cardiac arrest syndrome (PCAS) to improve the quality of...
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Contributing Factors on Pharmacokinetic Variability in Critically Ill Neonates

An SH

Neonates have large inter-individual variability in pharmacokinetic parameters of many drugs due to developmental differences. The aim of this study was to investigate the factors affecting the pharmacokinetic parameters of...
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Spinal Cord Injury and Related Clinical Trials

Kim YH, Ha KY, Kim SI

Spinal cord injury (SCI) has been considered an incurable condition and it often causes devastating sequelae. In terms of the pathophysiology of SCI, reducing secondary damage is the key to...
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Association between lactate clearance during post-resuscitation care and neurologic outcome in cardiac arrest survivors treated with targeted temperature management

Kim JC, Lee BK, Lee DH, Jung YH, Cho YS, Lee SM, Lee SJ, Park CH, Jeung KW

OBJECTIVE: We investigated the association between lactate clearance or serum lactate levels and neurologic outcomes or in-hospital mortality in cardiac arrest survivors who were treated with targeted temperature management (TTM). METHODS:...
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Successful Hysterectomy and Therapeutic Hypothermia Following Cardiac Arrest due to Postpartum Hemorrhage

Lee KH, Choi SJ, Jeon YG, Kim RK, Um DJ

Postpartum hemorrhage is a common cause of maternal mortality; its main cause is placenta accreta. Therapeutic hypothermia is a generally accepted means of improving clinical signs in postcardiopulmonary resuscitation patients....
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