J Korean Med Assoc.  2009 Dec;52(12):1173-1179. 10.5124/jkma.2009.52.12.1173.

Clinical Implementation of Therapeutic Hypothermia after Cardiac Arrest

  • 1Department of Emergency Medicine, Gacheon University College of Medicine, Korea. yanghj@gilhospital.com


Post-resuscitative induced hypothermia lowers mortality, reduces neurologic impairment after cardiac arrest, and is recommended by 2005 CPR guidelines of American Heart Association. This article reviews the mechanisms of hypothermic neuroprotection, the clinical trials that support its use after cardiac arrest, as well as the impact of hypothermia on patient management and prognosis. In caring for patients suffering ischemic brain injury after cardiac arrest, the role of the physician is no longer limited to conventional therapy but also extends to active involvement in clinical management which includes the use of therapeutic hypothermia. Therapeutic hypothermia is a feasible treatment and can be used safely and effectively at emergency department and ICU setting.


Cardiac arrest; Cardiopulmonary resuscitation; Therapeutic hypothermia

MeSH Terms

American Heart Association
Brain Injuries
Cardiopulmonary Resuscitation
Heart Arrest
Hypothermia, Induced
Stress, Psychological


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