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Decreased inward rectifier and voltage-gated K⁺ currents of the right septal coronary artery smooth muscle cells in pulmonary arterial hypertensive rats

Kim SE, Yin MZ, Kim HJ, Vorn R, Yoo HY, Kim SJ

In vascular smooth muscle, K⁺ channels, such as voltage-gated K⁺ channels (Kv), inward-rectifier K⁺ channels (Kir), and big-conductance Ca²⁺-activated K⁺ channels (BK(Ca)), establish a hyperpolarized membrane potential and counterbalance the...
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Biventricular Hypertrophic Cardiomyopathy with Severe Right Ventricular Outflow Track Obstruction

Lim DS, Lee CH

Hypertrophic cardiomyopathy (HCM) has diverse pathophysiological and clinical features, according to the extent and severity of the hypertrophy development. Hypertrophy mostly involves the left ventricle and sometimes causes a left...
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Protective Effect of Right Ventricular Mitochondrial Damage by Cyclosporine A in Monocrotaline-induced Pulmonary Hypertension

Lee DS, Jung YW

BACKGROUND AND OBJECTIVES: Mitochondria play a key role in the pathophysiology of heart failure and mitochondrial permeability transition pore (MPTP) play a critical role in cell death and a critical...
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Microarray Analysis in Pulmonary Hypertensive Rat Heart after Simvastatin Treatment

Kim YK, Kim KC, Hong YM

OBJECTIVES: Simvastatin has been reported to attenuate the development of pulmonary hypertension through increased apoptosis as well as reduced proliferation of smooth muscle cells in obstructive vascular lesions. Microarray experiment...
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Optimal Dose and Timing of Umbilical Stem Cells Treatment in Pulmonary Arterial Hypertensive Rats

Lee H, Kim KC, Choi SJ, Hong YM

PURPOSE: Pulmonary arterial hypertension (PAH) is a fatal disease which is characterized by an increase in pulmonary arterial pressure leading to increases in right ventricular afterload. Human umbilical cord blood...
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The effect of sildenafil on right ventricular remodeling in a rat model of monocrotaline-induced right ventricular failure

Bae HK, Lee H, Kim KC, Hong YM

PURPOSE: Pulmonary arterial hypertension (PAH) leads to right ventricular failure (RVF) as well as an increase in pulmonary vascular resistance. Our purpose was to study the effect of sildenafil on...
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Hypertrophic cardiomyopathy secondary to severe right and left ventricular outflow tract obstruction in a Maltese dog

Yoon WK, Suh SI, Oh YS, Hyun C

An 8-year-old spayed female Maltese (2.5 kg of body weight) presented with the primary complaint of loud heart murmur and exercise intolerance. Diagnostic imaging revealed severe pulmonic stenosis (peak velocity...
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The Effect of Umbilical Cord Blood Derived Mesenchymal Stem Cells in Monocrotaline-induced Pulmonary Artery Hypertension Rats

Lee H, Lee JC, Kwon JH, Kim KC, Cho MS, Yang YS, Oh W, Choi SJ, Seo ES, Lee SJ, Wang TJ, Hong YM

Pulmonary arterial hypertension (PAH) causes right ventricular failure due to a gradual increase in pulmonary vascular resistance. The purposes of this study were to confirm the engraftment of human umbilical...
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A Case of Asymptomatic Severe Pulmonary Valve Stenosis with Patent Foramen Ovale and Patent Ductus Arteriosus in an Adult

Kim SA, Her SH, Park MW, Na SJ, Kim HD, Kim JE, Kim WH

  • KMID: 2267792
  • Korean J Med.
  • 2013 Oct;85(4):406-410.
Pulmonary valve stenosis (PS) is the 3rd most common form of adult congenital heart disease. The patient was a 56-year-old woman, with known congenital heart disease but who was not...
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A case of fetal heterotaxy syndrome

Chon SJ, Kim SY, Lee SP, Hwang BC, Son DW, Choi CH

Heterotaxy syndrome is a disorder that results in abnormal placement of organs. We report the prenatal diagnosis of complex cardiac abnormalities associated with left isomerism. A 32-year-old multigravida was referred...
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Changes of Pulmonary Pathology and Gene Expressions After Simvastatin Treatment in the Monocrotaline-Induced Pulmonary Hypertension Rat Model

Lee YH, Kim KC, Cho MS, Hong YM

BACKGROUND AND OBJECTIVES: Simvastatin's properties are suggestive of a potential pathophysiologic role in pulmonary hypertension. The objectives of this study were to investigate changes of pulmonary pathology and gene expressions,...
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Simvastatin, Sildenafil and Their Combination in Monocrotaline Induced Pulmonary Arterial Hypertension

Lee DS, Kim YK, Jung YW

BACKGROUND AND OBJECTIVES: Pulmonary arterial hypertension (PAH) is a life threatening disease characterized by progressive pulmonary arterial occlusion which may ultimately result in death. Currently, the available treatments are diverse,...
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Characteristics of Double-Chambered Right Ventricle in Adult Patients

Choi YJ, Park SW

BACKGROUND/AIMS: This study evaluated the clinical features of double-chambered right ventricle (DCRV) in adults. Most cases of DCRV are diagnosed and treated during childhood. Consequently, very few reports include cases...
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Effect of endothelin receptor blockade on monocrotaline-induced pulmonary hypertension in rats

Lim KA, Shim JY, Cho SH, Kim KC, Han JJ, Hong YM

PURPOSE: To examine the effect of bosentan, a dual endothelin receptor (ER) antagonist, on the development of monocrotaline (MCT)-induced pulmonary hypertension in rats by especially focusing on the pulmonary vascular...
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The Protective Effect of Simvastatin on Monocrotaline-Induced Pulmonary Hypertension in Rats

Kim MY, Kim YK, Jung YW, Kim WT, Kwon TH, Lee DS

BACKGROUND AND OBJECTIVES: Pulmonary hypertension is characterized by abnormal proliferation of vascular endothelial cells and smooth muscle cells, and progressive pulmonary microvascular leakage that leads to pulmonary edema. This study...
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Changes in the Lung after Pulmonary Hypertension Induced by Obstruction of the Pulmonary Vein in Rats

Jang WC, Jeong IS, Cho KS, Oh BS

  • KMID: 1878598
  • Korean J Thorac Cardiovasc Surg.
  • 2006 Sep;39(9):659-667.
BACKGROUND: Experimental studies of vascular remodeling in the pulmonary arteries have been performed actively. These models required a persistent vascular insult for intimal injury induced by chronic hypoxia, monocrotaline intoxication...
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The Utility of Measurement of Plasma N-terminal Pro-brain Natriuretic Peptide in Diagnosis of Pulmonary Hypertension

Hahn CH, Kang SM, Moon JW, Cho JH, Hwang SY, Lee JM, Park MS, Chung JH, Kim YS, Kim SK, Chang J, Shim WH, Kim SK

  • KMID: 2318466
  • Tuberc Respir Dis.
  • 2004 Jan;56(1):67-76.
BACKGROUND: Pulmonary hypertension is a poor prognostic factor in patients with chronic respiratory disease. However, diagnosing pulmonary hypertension is a difficult procedure which often requires an invasive test. Thus new...
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Estrogen and Enalapril attenuate the Development of Right Ventricular Hypertrophy induced by Monocrotaline in Ovariectomized Rats

Ahn BH, Park HK, Cho HG, Lee HA, Lee YM, Yang EK, Lee WJ

The present study evaluated the importance of ovarian functions and the renin-angiotensin system in the progression of the right ventricular (RV) hypertrophy. Female Sprague-Dawley rats were bilaterally ovariectomized (Ovx) and...
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Enhanced Expression of Aldosterone Synthase and Adrenomedullin in Left and Right Ventricular Hypertrophy in Rats

Lee JU, Lee S, Kim S, Lee WJ

  • KMID: 1615003
  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):121-126.
The pathophysiological implications of aldosterone and adrenomedullin in the cardiac ventricular hypertrophy were examined. Male Sprague-Dawley rats were treated with deoxycorticosterone acetate (DOCA)-salt and monocrotaline (MCT) to selectively elicit left...
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Increased expression of nitric oxide synthases in left and right ventricular hypertrophy

Lee JU, Oh YW, Kim S, Kang DG, Lee WJ

  • KMID: 1606840
  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):65-70.
The present study was aimed to explore pathophysiological implications of nitric oxide in the development of left and right ventricular hypertrophy. To induce selective left and right ventricular hypertrophy, rats were made two-kidney,...
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