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Blood electrolyte disturbances during severe hypoglycemia in Korean patients with type 2 diabetes

Kang MY

BACKGROUND/AIMS: To investigate abnormalities in blood electrolyte levels during severe hypoglycemia in Korean patients with type 2 diabetes mellitus (T2DM) in a clinical setting. METHODS: Blood electrolyte levels in adult T2DM...
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Augmented expression of cardiac atrial natriuretic peptide system in hypertensive rats

An MR, Chung YJ, Kang DG, Nam SC, Lee JU

The present study was aimed at investigating the regulation of atrial natriuretic peptide (ANP) system in association with either enhanced or attenuated activity of the renin-angiotensin system (RAS). The cardiac...
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Environmental Heavy Metal Exposure and Chronic Kidney Disease in the General Population

Kim NH, Hyun YY, Lee KB, Chang Y, Rhu S, Oh KH, Ahn C

Lead (Pb), mercury (Hg), and cadmium (Cd) are common heavy metal toxins and cause toxicological renal effects at high levels, but the relevance of low-level environmental exposures in the general...
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Differential brain angiotensin-II type I receptor expression in hypertensive rats

Braga VA

Blood-borne angiotensin-II (Ang-II) has profound effects in the brain. We tested the hypothesis that Ang-II-dependent hypertension involves differential Ang-II type I (AT1) receptors expression in the subfornical organ (SFO) and...
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Differentially-altered vascular guanylate cyclase isoforms in experimental hypertensive rats

Lee JU, Kang DG, Kook H, Kim IK, Oh BS

Pathophysiological implications of the vascular nitric oxide (NO)/cGMP pathway were investigated in various rat models of hypertension. The expression of brain and endothelial constitutive NO synthases (bNOS, ecNOS) was determined...
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Expression of NAD(P)H Oxidase Subunits and Their Contribution to Cardiovascular Damage in Aldosterone/Salt-Induced Hypertensive Rat

Park YM, Lim BH, Touyz RM, Park JB

NAD(P)H oxidase plays an important role in hypertension and its complication in aldosterone-salt rat. We questioned whether NAD(P)H oxidase subunit expression and activity are modulated by aldosterone and whether this...
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