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Measuring Intrahepatic Vascular Changes Using Contrast-Enhanced Ultrasonography to Predict the Prognosis of Alcoholic Hepatitis Combined with Cirrhosis: A Prospective Pilot Study

Park MS, Hong S, Lim YL, Kang SH, Baik SK, Kim MY

BACKGROUND/AIMS: Acute hepatic dysfunction combined with alcoholic hepatitis (AH) in alcoholic cirrhosis is related to hepatic hypo-perfusion secondary to intrahepatic necroinflammation, neoangiogenesis, and shunt. The hepatic vein arrival time (HVAT)...
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Expression of Fibroblast Growth Factor 21 and β-Klotho Regulates Hepatic Fibrosis through the Nuclear Factor-κB and c-Jun N-Terminal Kinase Pathways

Lee KJ, Jang YO, Cha SK, Kim MY, Park KS, Eom YW, Baik SK

BACKGROUND/AIMS: Fibroblast growth factor (FGF) 21 is associated with hepatic inflammation and fibrosis. However, little is known regarding the effects of inflammation and fibrosis on the β-Klotho and FGF21 pathway...
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Role of liver transplantation in severe alcoholic hepatitis

Daswani R, Kumar A, Sharma P, Singla V, Bansal N, Arora A

Severe alcoholic hepatitis has very high short term mortality and corticosteroids have been the mainstay of treatment for decades. Patients with Lille score >0.45 are considered non-responders to steroids and...
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Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story

Obed A, Bashir A, Stern S, Jarrad A

Severe acute alcoholic liver disease (SAAH) unresponsive to medical therapy shows one-year-mortality rates of up to 90%. Most transplant centers request six months of alcohol abstinence prior to transplantation, the...
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The Role of Bile Acid Receptors in Chronic Inflammatory Diseases

Park R, Ji JD

With recent developments, biologic therapies has shown superior efficacy for rheumatic diseases compared with preexisting pharmacologic therapies, which are associated with high costs, non-response in certain patient groups, and severe...
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Case of Bile Canalicular Antibody in a Korean Patient with Alcoholic Hepatitis

Kim SH, Jearn LH, Kim TY, Choi HS

Bile canalicular antibody (BCA) was first reported in 1969. Many studies of BCA were performed in the 1970s and 1980s and revealed that BCA has a highly positive rate in...
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Acute-on-chronic liver failure: a new syndrome in cirrhosis

Moreau R

Patients with cirrhosis who are hospitalized for an acute decompensation (AD) and also have organ failure(s) are at high risk of short-term death. These patients have a syndrome called Acute-on-Chronic...
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Management of Intramural Esophageal Dissection with Gastric Feeding Tube in an Alcoholic-hepatitis Patient

Ko RE, Jung WS, Lee YC, Choi SH, Seo SY

Intramural esophageal dissection is a rare but clinically important condition in the field of gastroenterology. Classically, intramural esophageal dissection rarely occurs in patients who are anticoagulated or have poor medical...
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Diagnostic and Therapeutic Strategies for Severe Alcoholic Hepatitis

Kim W

Alcoholic hepatitis (AH) is defined as an acute hepatic manifestation resulting from heavy alcohol intake. Histologically, alcoholic steatohepatitis (ASH) is characterized by hepatocellular steatosis, inflammation, and fibrosis. Alcohol abstinence is...
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Comparison on the Efficacy and Safety of Biphenyl Dimethyl Dicarboxylate and Ursodeoxycholic Acid in Patients with Abnormal Alanine Aminotransferase: Multicenter, Double-blinded, Randomized, Active-controlled Clinical Trial

Lee SH, Cheon GJ, Kim HS, Kim YD, Kim SG, Kim YS, Jeong SW, Jang JY, Kim BS

BACKGROUND/AIMS: Chronic hepatocellular damage is closely associated with hepatic fibrosis and fatal complication in most liver diseases. The aim of this study is to compare the efficacy and safety of...
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KASL Clinical Practice Guidelines: Management of Alcoholic Liver Disease

The Korean Association for the Study of the Liver (KASL)

No abstract available.
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A Suspicious Case of Chloroform Induced Acute Toxic Hepatitis in Laboratory Worker

Lee DG, Lee CH, Jang KH, Chae HJ, Moon JD

  • KMID: 2075184
  • Korean J Occup Environ Med.
  • 2012 Sep;24(3):304-310.
OBJECTIVES: To report upon a case of toxic hepatitis in a worker exposed to chloroform. METHODS: A 28-year-old female who had worked as chemical analysis engineer in a laboratory using chloroform...
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Cilostazol Decreases Ethanol-Mediated TNFalpha Expression in RAW264.7 Murine Macrophage and in Liver from Binge Drinking Mice

Lee YJ, Eun JR

Alcoholic hepatitis is a leading cause of liver failure in which the increased production of tumor necrosis factor alpha (TNFalpha) plays a critical role in progression of alcoholic liver disease....
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Screening and surveillance of hepatocellular carcinoma

Lee MA

  • KMID: 2259087
  • Korean J Med.
  • 2010 Sep;79(3):224-230.
Hepatocellular carcinoma (HCC) is common cancer in Korea. Although HCC has been decreased recently, mortality rate is still high, especially in the 6th decades in men. While hepatitis B and...
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The usefulness of transient elastography to diagnose cirrhosis in patients with alcoholic liver disease

Kim SG, Kim YS, Jung SW, Kim HK, Jang JY, Moon JH, Kim HS, Lee JS, Lee MS, Shim CS, Kim BS

BACKGROUNDS/AIMS: It is not easy to differentiate between patients with cirrhosis and those with alcoholic liver disease. Liver biopsy is generally considered the gold standard for assessing hepatic fibrosis; however,...
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A Comparative Cross-sectional Study of the Development of Hepatocellular Carcinoma in Patients with Liver Cirrhosis Caused by Hepatitis B Virus, Alcohol, or Combination of Hepatitis B Virus and Alcohol

Chung NS, Kwon OS, Park CH, Kim YN, Cho GH, Lee JJ, Kim GH, Kim HO, Ko KI, Yu SK, Kwon KA, Kim YS, Choi DJ, Kim JH

  • KMID: 782873
  • Korean J Gastroenterol.
  • 2007 Jun;49(6):369-375.
BACKGROUND/AIMS: Alcohol may be a cocarcinogen in patients with chronic viral hepatitis. We investigated the effect of alcohol on the development of hepatocellular carcinoma (HCC) in liver cirrhosis (LC)...
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Comparison of Model for End-stage Liver Disease Score with Discriminant Function and Child-Turcotte-Pugh Scores for Predicting Short-term Mortality in Korean Patients with Alcoholic Hepatitis

Jeong JY, Sohn JH, Son BK, Paik CH, Kim SH, Han DS, Jeon YC, Lee MH, Lee DH, Kee CS

  • KMID: 935185
  • Korean J Gastroenterol.
  • 2007 Feb;49(2):93-99.
BACKGROUND/AIMS: Alcoholic hepatitis is an acute or acute-on-chronic inflammatory syndrome associated with significant morbidity and mortality. Traditionally, Maddrey discriminant function (DF) score and Child-Turcott- Pugh (CTP) score have been used...
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Alcoholic Hepatitis

Jin SY

  • KMID: 760652
  • Korean J Hepatol.
  • 2006 Jun;12(2):243-246.
No abstract available.
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Drug Induced Hepatitis Mimicking Alcoholic Hepatitis

Kang DY, Jin SY

  • KMID: 938263
  • Korean J Hepatol.
  • 2006 Dec;12(4):574-578.
No abstract available.
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Clinical Characteristics of Alcoholic Ketoacidosis in Patients with Chronic Alcoholic Ingestion

Kim HJ, Yang JW, Han BG, Lee MK, Kim JS, Yoo JM, Han ST, Choi JW, Kim MS, Choi SO

  • KMID: 1867695
  • Korean J Nephrol.
  • 2006 Nov;25(6):923-931.
BACKGROUND:Alcoholic ketoacidosis is a common disorder observed in chronic alcoholics with metabolic acidosis but there were only several reports. This study was undertaken to evaluate the clinical characteristics of alcoholic...
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