- 15-Deoxy-Δ(12,14)-prostaglandin J₂ Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells
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Park JM, Na HK
- KMID: 2468800
- J Cancer Prev.
- 2019 Sep;24(3):183-191.
- doi: 10.15430/JCP.2019.24.3.183
BACKGROUND: Abnormal upregulation of prostaglandin Eâ‚‚ (PGEâ‚‚) is considered to be a key oncogenic event in the development and progression of inflammation-associated human colon cancer. It has been reported that... -
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- Effects of heme oxygenase-1 upregulation on isoproterenol-induced myocardial infarction
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Eltobshy S, Hussein AM, Elmileegy , Askar MH, Khater Y, Metias EF, Helal GM
- KMID: 2443608
- Korean J Physiol Pharmacol.
- 2019 May;23(3):203-217.
- doi: 10.4196/kjpp.2019.23.3.203
The present study was designed to examine the effect of heme oxygenase-1 (HO-1) induction by cobalt protoporphyrin (CoPP) on the cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide... -
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- Vitamin D Improves Intestinal Barrier Function in Cirrhosis Rats by Upregulating Heme Oxygenase-1 Expression
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Wang PF, Yao DH, Hu YY, Li Y
- KMID: 2442015
- Biomol Ther.
- 2019 Feb;27(2):222-230.
- doi: 10.4062/biomolther.2018.052
Intestinal barrier dysfunction always accompanies cirrhosis in patients with advanced liver disease and is an important contributor facilitating bacterial translocation (BT), which has been involved in the pathogenesis of cirrhosis... -
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- The Effect of ABO Blood Groups, Hemoglobinopathy, and Heme Oxygenase-1 Polymorphisms on Malaria Susceptibility and Severity
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Kuesap J, Na-Bangchang K
- KMID: 2412735
- Korean J Parasitol.
- 2018 Apr;56(2):167-173.
- doi: 10.3347/kjp.2018.56.2.167
Malaria is one of the most important public health problems in tropical areas on the globe. Several factors are associated with susceptibility to malaria and disease severity, including innate immunity... -
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- Lithium ameliorates rat spinal cord injury by suppressing glycogen synthase kinase-3β and activating heme oxygenase-1
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Kim Y, Kim J, Ahn M, Shin T
- KMID: 2390482
- Anat Cell Biol.
- 2017 Sep;50(3):207-213.
- doi: 10.5115/acb.2017.50.3.207
Glycogen synthase kinase (GSK)-3β and related enzymes are associated with various forms of neuroinflammation, including spinal cord injury (SCI). Our aim was to evaluate whether lithium, a non-selective inhibitor of... -
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- Heme Oxygenase-1 Induction and Anti-inflammatory Actions of Atractylodes macrocephala and Taraxacum herba Extracts Prevented Colitis and Was More Effective than Sulfasalazine in Preventing Relapse
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Han KH, Park JM, Jeong M, Han YM, Go EJ, Park J, Kim H, Han JG, Kwon O, Hahm KB
- KMID: 2389354
- Gut Liver.
- 2017 Sep;11(5):655-666.
- doi: 10.5009/gnl16496
BACKGROUND/AIMS: In inflammatory bowel disease (IBD), repeated bouts of remission and relapse occur in patients and can impose a risk of colitis-associated cancer. We hypothesized that plant extracts of Atractylodes... -
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- Induction of heme oxygenase-1 with dietary quercetin reduces obesity-induced hepatic inflammation through macrophage phenotype switching
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Kim CS, Choi HS, Joe Y, Chung HT, Yu R
- KMID: 2359619
- Nutr Res Pract.
- 2016 Dec;10(6):623-628.
- doi: 10.4162/nrp.2016.10.6.623
BACKGROUND/OBJECTIVES: Obesity-induced steatohepatitis accompanied by activated hepatic macrophages/Kupffer cells facilitates the progression of hepatic fibrinogenesis and exacerbates metabolic derangements such as insulin resistance. Heme oxyganase-1 (HO-1) modulates tissue macrophage phenotypes... -
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- Iron Contents in Rice Food Derived from the Iron Pot, and In Vitro Study Regarding Heme Oxygenase-1 Activity
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Kim KY, An YM, Kim TW, Jun YH, Lee JE, Jang JH, Kim SK
- KMID: 2358362
- Clin Pediatr Hematol Oncol.
- 2016 Oct;23(2):77-82.
- doi: 10.15264/cpho.2016.23.2.77
BACKGROUND: Iron pots have long been used for cooking in several countries. Early studies have shown that the use of such iron pots can increase the iron content of food... -
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- Fraxetin Induces Heme Oxygenase-1 Expression by Activation of Akt/Nrf2 or AMP-activated Protein Kinase α/Nrf2 Pathway in HaCaT Cells
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Kundu J, Chae IG, Chun KS
- KMID: 2367571
- J Cancer Prev.
- 2016 Sep;21(3):135-143.
- doi: 10.15430/JCP.2016.21.3.135
BACKGROUND: Fraxetin (7,8-dihydroxy-6-methoxy coumarin), a coumarin derivative, has been reported to possess antioxidative, anti-inflammatory and neuroprotective effects. A number of recent observations suggest that the induction of heme oxygenase-1 (HO-1)... -
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- Isoegomaketone Upregulates Heme Oxygenase-1 in RAW264.7 Cells via ROS/p38 MAPK/Nrf2 Pathway
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Jin CH, So YK, Han SN, Kim JB
- KMID: 2351675
- Biomol Ther.
- 2016 Sep;24(5):510-516.
- doi: 10.4062/biomolther.2015.194
Isoegomaketone (IK) was isolated from Perilla frutescens, which has been widely used as a food in Asian cuisine, and evaluated for its biological activity. We have already confirmed that IK... -
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- Neuroprotective Effects of Betaxolol Mediated by Heme Oxygenase-1 Induction in RGC-5
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Cha JB, Kwon MY, Chung SW, Woo JM
- KMID: 2213854
- J Korean Ophthalmol Soc.
- 2016 Jan;57(1):113-119.
- doi: 10.3341/jkos.2016.57.1.113
PURPOSE: To evaluate the neuroprotective effects of betaxolol (betaxolol hydrochloride) under hypoxic conditions using retinal ganglion cells (RGC-5) and determine whether heme oxygenase-1 (HO-1) expression exerts cytoprotective effects. METHODS: In this... -
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- Modulation of Melanogenesis by Heme Oxygenase-1 via p53 in Normal Human Melanocytes
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Lim HS, Jin S, Yun SJ
- KMID: 2152655
- Chonnam Med J.
- 2016 Jan;52(1):45-52.
- doi: 10.4068/cmj.2016.52.1.45
As a key regulator of melanogenesis, p53 controls microphthalmia-associated transcription factor (MITF) and tyrosinase expression. The anti-oxidant enzyme heme oxygenase-1 (HO-1) is induced by various forms of cellular stress and... -
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- Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells
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Kim MK, Park HJ, Kim SR, Choi YK, Bae SK, Bae MK
- KMID: 2285575
- Korean J Physiol Pharmacol.
- 2015 Jul;19(4):327-334.
- doi: 10.4196/kjpp.2015.19.4.327
The cytoprotective enzyme heme oxygenase-1 (HO-1) influences endothelial cell survival, proliferation, inflammatory response, and angiogenesis in response to various angiogenic stimuli. In this study, we investigate the involvement of HO-1... -
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- TI-I-174, a Synthetic Chalcone Derivative, Suppresses Nitric Oxide Production in Murine Macrophages via Heme Oxygenase-1 Induction and Inhibition of AP-1
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Kim MJ, Kadayat T, Kim DE, Lee ES, Park PH
- KMID: 2380315
- Biomol Ther.
- 2014 Sep;22(5):390-399.
- doi: 10.4062/biomolther.2014.062
Chalcones (1,3-diaryl-2-propen-1-ones), a flavonoid subfamily, are widely known for their anti-inflammatory properties. Propenone moiety in chalcones is known to play an important role in generating biological responses by chalcones. In... -
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- Sildenafil Inhibits Advanced Glycation End Products-induced sFlt-1 Release Through Upregulation of Heme Oxygenase-1
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Jeong JH, Kim HG, Choi OH
- KMID: 2325443
- J Menopausal Med.
- 2014 Aug;20(2):57-68.
- doi: 10.6118/jmm.2014.20.2.57
OBJECTIVES: We examined the effect of sildenafil citrate on advanced glycation end products (AGEs)-induced soluble fms-like tyrosine kinase 1 (sFlt-1) release in JEG-3 choriocarcinoma cells. METHODS: Cells were incubated with control... -
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- Anti-inflammatory effect of methanol extract from Erigeron Canadensis L. may be involved with upregulation of heme oxygenase-1 expression and suppression of NFkappaB and MAPKs activation in macrophages
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Sung J, Sung M, Kim Y, Ham H, Jeong HS, Lee J
- KMID: 2313750
- Nutr Res Pract.
- 2014 Aug;8(4):352-359.
BACKGROUND/OBJECTIVES: In this study, we determined the anti-inflammatory activities and the underlying molecular mechanisms of the methanol extract from Erigeron Canadensis L. (ECM) in LPS-stimulated RAW264.7 macrophage cells. MATERIALS/METHODS: The potential... -
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- Induction of Heme Oxygenase-1 by Traditional Herb Mix Extract Improves MKN-74 Cell Survival and Reduces Stomach Bleeding in Rats by Ethanol and Aspirin in vivo
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Kang YJ, Moon HS, Kim HJ, Seo HG, Lee JH, Chang KC
- KMID: 1512909
- Korean J Physiol Pharmacol.
- 2007 Apr;11(2):65-70.
Chinese herb medicines have traditionally been used to treat or alleviate the symptom of various diseases. The rationale for use of certain herbs to certain disorder is now getting unveiled... -
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- The Effect of Inhibition of Heme Oxygenase-1 on Chemosensitivity of Cisplatin in Lung Cancer Cells
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Kim SY, Kim EJ, Jang HY, Hwang KE, Park JH, Kim HJ, Jo HJ, Yang SH, Jeong ET, Kim HR
- KMID: 1518487
- Tuberc Respir Dis.
- 2007 Jan;62(1):33-42.
- doi: 10.4046/trd.2007.62.1.33
BACKGROUND: Heme oxygenase-1 (HO-1) is known to modulates the cellular functions, including cell proliferation and apoptosis. It is known that a high level of HO-1 expression is found in many... -
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- The Effects of Heme Oxygenase-1 on Collagen Induced Arthritis Model
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Jang SJ, Kim YR, Choi EY, Lee EG, Kim KS, Kwon DS, Oh JM, Choi MK, Lee BK, Yang CY, Kim JW, Chun CH, Song HH, Kim HS, Yun KJ, Lee MS
- KMID: 2092881
- Korean J Anat.
- 2006 Oct;39(5):393-399.
Heme oxygenase-1 (HO-1), an inducible heme-degrading enzyme, is expressed by macrophages and endothelial cells in response to inflammatory stresses. It has been known to show strong immunosuppressive properties although its mechanisms are... -
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- Heme Oxygenase-1 via Transcriptional Activation of Nrf2 Attenuates Apoptosis in Lung Cancer Cells
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Kim HR, Kim EJ, Hwang KE, Kim SY, Park SH, Park JH, Kim HJ, Yang SH, Jeong ET
- KMID: 1881525
- J Lung Cancer.
- 2006 Jun;5(1):39-46.
- doi: 10.6058/jlc.2006.5.1.39
PURPOSE : Increasing evidences have indicated the critical role of HO-1 in cytoprotection and more diverse biological functions. HO-1 has been reported to stimulate tumor cell growth and proliferation. And... -
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