- Anti-Helicobacter pylori, Anti-apoptotic, and Cytoprotective Effects of Threonine Synthesized from Corynebacterium glutamicum in Gastric Epithelial Cells
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An JM, Kim YS, Hong YG, Hah BS, Sohn MS, Hahm KB
- KMID: 2469316
- Korean J Helicobacter Up Gastrointest Res.
- 2019 Dec;19(4):245-256.
- doi: 10.7704/kjhugr.2019.0011
BACKGROUND/AIMS: Among irritants causing gastric ulcer, Helicobacter pylori (H. pylori) might be pivotal, after which eradication became essential way in either inhibiting ulcerogenesis or preventing ulcer recurrence. Since threonine is... -
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- Platycarya strobilacea leaf extract protects mice brain with focal cerebral ischemia by antioxidative property
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Lee JH, Jeong JH, Jeong YG, Kim DK, Lee NS, Na CS, Doh ES, Han SY
- KMID: 2466703
- Anat Cell Biol.
- 2019 Dec;52(4):486-497.
- doi: 10.5115/acb.19.141
The leaf extract of Platycarya strobilacea (PSL) has long been recognized as possessing various health-promoting activities. However, information on its possible protective effects against ischemic stroke is currently lacking. Here,... -
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- 15-Deoxy-Δ(12,14)-prostaglandin J₂ Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells
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Park JM, Na HK
- KMID: 2468800
- J Cancer Prev.
- 2019 Sep;24(3):183-191.
- doi: 10.15430/JCP.2019.24.3.183
BACKGROUND: Abnormal upregulation of prostaglandin Eâ‚‚ (PGEâ‚‚) is considered to be a key oncogenic event in the development and progression of inflammation-associated human colon cancer. It has been reported that... -
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- Protective Effects of Ursolic Acid on Osteoblastic Differentiation via Activation of IER3/Nrf2
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Lee SI
- KMID: 2460998
- J Dent Hyg Sci.
- 2019 Sep;19(3):198-204.
- doi: 10.17135/jdhs.2019.19.3.198
BACKGROUND: Oxidative stress is a known to be associated with in the pathogenesis of many inflammatory diseases, including periodontitis. Ursolic acid is a pentacyclic triterpenoid with has antimicrobial, antioxidative, and... -
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- Nrf2-Heme oxygenase-1 modulates autophagy and inhibits apoptosis triggered by elevated glucose levels in renal tubule cells
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Kim JH, Kim KM, Jeong JU, Shin JH, Shin JM, Bang KT
- KMID: 2457723
- Kidney Res Clin Pract.
- 2019 Sep;38(3):318-325.
- doi: 10.23876/j.krcp.18.0152
BACKGROUND: Autophagy is a highly balanced process in which lysosomes remove aged and damaged organelles and cellular proteins. Autophagy is essential to maintain homeostasis in the kidneys. METHODS: Using human renal... -
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- Effects of heme oxygenase-1 upregulation on isoproterenol-induced myocardial infarction
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Eltobshy S, Hussein AM, Elmileegy , Askar MH, Khater Y, Metias EF, Helal GM
- KMID: 2443608
- Korean J Physiol Pharmacol.
- 2019 May;23(3):203-217.
- doi: 10.4196/kjpp.2019.23.3.203
The present study was designed to examine the effect of heme oxygenase-1 (HO-1) induction by cobalt protoporphyrin (CoPP) on the cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide... -
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- Neuroprotective mechanisms of dieckol against glutamate toxicity through reactive oxygen species scavenging and nuclear factor-like 2/heme oxygenase-1 pathway
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Cui Y, Amarsanaa , Lee JH, Rhim JK, Kwon JM, Kim SH, Park JM, Jung SC, Eun SY
- KMID: 2438086
- Korean J Physiol Pharmacol.
- 2019 Mar;23(2):121-130.
- doi: 10.4196/kjpp.2019.23.2.121
Glutamate toxicity-mediated mitochondrial dysfunction and neuronal cell death are involved in the pathogenesis of several neurodegenerative diseases as well as acute brain ischemia/stroke. In this study, we investigated the neuroprotective... -
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- Vitamin D Improves Intestinal Barrier Function in Cirrhosis Rats by Upregulating Heme Oxygenase-1 Expression
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Wang PF, Yao DH, Hu YY, Li Y
- KMID: 2442015
- Biomol Ther.
- 2019 Feb;27(2):222-230.
- doi: 10.4062/biomolther.2018.052
Intestinal barrier dysfunction always accompanies cirrhosis in patients with advanced liver disease and is an important contributor facilitating bacterial translocation (BT), which has been involved in the pathogenesis of cirrhosis... -
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- Evaluation of in vitro anti-oxidant and anti-inflammatory activities of Korean and Chinese Lonicera caerulea
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Lee YS, Cho IJ, Kim JW, Lee SK, Ku SK, Lee HJ
- KMID: 2448693
- Nutr Res Pract.
- 2018 Dec;12(6):486-493.
- doi: 10.4162/nrp.2018.12.6.486
BACKGROUND/OBJECTIVES: The honeysuckle berry (HB) contains ascorbic acid and phenolic components, especially anthocyanins, flavonoids, and low-molecular-weight phenolic acids. In order to examine the potential of HB as a hepatoprotective medicinal... -
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- rBMSCs/ITGA5B1 Promotes Human Vascular Smooth Muscle Cell Differentiation via Enhancing Nitric Oxide Production
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Zhang Y, Ding J, Xu C, Yang H, Xia P, Ma S, Chen H
- KMID: 2429549
- Int J Stem Cells.
- 2018 Nov;11(2):168-176.
- doi: 10.15283/ijsc18079
BACKGROUND AND OBJECTIVES: Previous studies have shown that integrins alpha5beta1 (ITGA5B1) gene-modified rat bone marrow mesenchymal stem cells (rBMSCs) could prevent cell anoikis and increase the nitric oxide (NO) production.... -
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- The Novel Neuroprotective Compound KMS99220 Has an Early Anti-neuroinflammatory Effect via AMPK and HO-1, Independent of Nrf2
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Lee JA, Kim HR, Kim J, Park KD, Kim DJ, Hwang O
- KMID: 2424735
- Exp Neurobiol.
- 2018 Oct;27(5):408-418.
- doi: 10.5607/en.2018.27.5.408
We have previously reported a novel synthetic compound KMS99220 that prevented degeneration of the nigral dopaminergic neurons and the associated motor deficits, suggesting a neuroprotective therapeutic utility for Parkinson's disease.... -
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- The Effect of ABO Blood Groups, Hemoglobinopathy, and Heme Oxygenase-1 Polymorphisms on Malaria Susceptibility and Severity
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Kuesap J, Na-Bangchang K
- KMID: 2412735
- Korean J Parasitol.
- 2018 Apr;56(2):167-173.
- doi: 10.3347/kjp.2018.56.2.167
Malaria is one of the most important public health problems in tropical areas on the globe. Several factors are associated with susceptibility to malaria and disease severity, including innate immunity... -
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- Carbon Monoxide Ameliorates 6-Hydroxydopamine-Induced Cell Death in C6 Glioma Cells
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Moon H, Jang JH, Jang TC, Park GH
- KMID: 2429057
- Biomol Ther.
- 2018 Mar;26(2):175-181.
- doi: 10.4062/biomolther.2018.009
Carbon monoxide (CO) is well-known as toxic gas and intrinsic signaling molecule such as neurotransmitter and blood vessel relaxant. Recently, it has been reported that low concentration of CO exerts... -
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- Effects of selenium on the survival and invasion of trophoblasts
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Na JY, Seok J, Park S, Kim JS, Kim GJ
- KMID: 2408571
- Clin Exp Reprod Med.
- 2018 Mar;45(1):10-16.
- doi: 10.5653/cerm.2018.45.1.10
OBJECTIVE: Placental oxidative stress is known to be a factor that contributes to pregnancy failure. The aim of this study was to determine whether selenium could induce antioxidant gene expression... -
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- Caffeic acid phenethyl ester protects against photothrombotic cortical ischemic injury in mice
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Hwang SA, Kim CD, Lee WS
- KMID: 2398560
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):101-110.
- doi: 10.4196/kjpp.2018.22.1.101
In this study, we aimed to investigate the neuroprotective effects of caffeic acid phenethyl ester (CAPE), an active component of propolis purified from honeybee hives, on photothrombotic cortical ischemic injury... -
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- Effect of canine mesenchymal stromal cells overexpressing heme oxygenase-1 in spinal cord injury
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Lee SH, Kim Y, Rhew D, Kim A, Jo KR, Yoon Y, Choi KU, Jung T, Kim WH, Kweon OK
- KMID: 2412456
- J Vet Sci.
- 2017 Sep;18(3):377-386.
- doi: 10.4142/jvs.2017.18.3.377
Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that modulates the immune response and oxidative stress associated with spinal cord injury (SCI). This study aimed to investigate neuronal regeneration via transplantation... -
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- Lithium ameliorates rat spinal cord injury by suppressing glycogen synthase kinase-3β and activating heme oxygenase-1
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Kim Y, Kim J, Ahn M, Shin T
- KMID: 2390482
- Anat Cell Biol.
- 2017 Sep;50(3):207-213.
- doi: 10.5115/acb.2017.50.3.207
Glycogen synthase kinase (GSK)-3β and related enzymes are associated with various forms of neuroinflammation, including spinal cord injury (SCI). Our aim was to evaluate whether lithium, a non-selective inhibitor of... -
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- Heme Oxygenase-1 Induction and Anti-inflammatory Actions of Atractylodes macrocephala and Taraxacum herba Extracts Prevented Colitis and Was More Effective than Sulfasalazine in Preventing Relapse
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Han KH, Park JM, Jeong M, Han YM, Go EJ, Park J, Kim H, Han JG, Kwon O, Hahm KB
- KMID: 2389354
- Gut Liver.
- 2017 Sep;11(5):655-666.
- doi: 10.5009/gnl16496
BACKGROUND/AIMS: In inflammatory bowel disease (IBD), repeated bouts of remission and relapse occur in patients and can impose a risk of colitis-associated cancer. We hypothesized that plant extracts of Atractylodes... -
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- Antioxidant mechanism of black garlic extract involving nuclear factor erythroid 2-like factor 2 pathway
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Ha AW, Kim WK
- KMID: 2407768
- Nutr Res Pract.
- 2017 Jun;11(3):206-213.
- doi: 10.4162/nrp.2017.11.3.206
BACKGROUN/OBJECTIVES: Although studies have revealed that black garlic is a potent antioxidant, its antioxidant mechanism remains unclear. The objective of this study was to determine black garlic's antioxidant activities and... -
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- Induction of heme oxygenase-1 with dietary quercetin reduces obesity-induced hepatic inflammation through macrophage phenotype switching
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Kim CS, Choi HS, Joe Y, Chung HT, Yu R
- KMID: 2359619
- Nutr Res Pract.
- 2016 Dec;10(6):623-628.
- doi: 10.4162/nrp.2016.10.6.623
BACKGROUND/OBJECTIVES: Obesity-induced steatohepatitis accompanied by activated hepatic macrophages/Kupffer cells facilitates the progression of hepatic fibrinogenesis and exacerbates metabolic derangements such as insulin resistance. Heme oxyganase-1 (HO-1) modulates tissue macrophage phenotypes... -
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