- The Association between Maternal Dietary Iron Intake during the First Trimester of Pregnancy with Pregnancy Outcomes and Pregnancy-Related Complications
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Hajianfar , Abbasi K, Azadbakht , Esmaeilzadeh A, Mollaghasemi N, Arab A
- KMID: 2468664
- Clin Nutr Res.
- 2020 Jan;9(1):52-62.
- doi: 10.7762/cnr.2020.9.1.52
In this study, we investigated the associations of maternal dietary iron intake during the first trimester of pregnancy and pregnancy outcomes and related complications in pregnant women of Isfahan, Iran.... -
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- Anti-Helicobacter pylori, Anti-apoptotic, and Cytoprotective Effects of Threonine Synthesized from Corynebacterium glutamicum in Gastric Epithelial Cells
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An JM, Kim YS, Hong YG, Hah BS, Sohn MS, Hahm KB
- KMID: 2469316
- Korean J Helicobacter Up Gastrointest Res.
- 2019 Dec;19(4):245-256.
- doi: 10.7704/kjhugr.2019.0011
BACKGROUND/AIMS: Among irritants causing gastric ulcer, Helicobacter pylori (H. pylori) might be pivotal, after which eradication became essential way in either inhibiting ulcerogenesis or preventing ulcer recurrence. Since threonine is... -
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- Platycarya strobilacea leaf extract protects mice brain with focal cerebral ischemia by antioxidative property
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Lee JH, Jeong JH, Jeong YG, Kim DK, Lee NS, Na CS, Doh ES, Han SY
- KMID: 2466703
- Anat Cell Biol.
- 2019 Dec;52(4):486-497.
- doi: 10.5115/acb.19.141
The leaf extract of Platycarya strobilacea (PSL) has long been recognized as possessing various health-promoting activities. However, information on its possible protective effects against ischemic stroke is currently lacking. Here,... -
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- 15-Deoxy-Δ(12,14)-prostaglandin J₂ Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells
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Park JM, Na HK
- KMID: 2468800
- J Cancer Prev.
- 2019 Sep;24(3):183-191.
- doi: 10.15430/JCP.2019.24.3.183
BACKGROUND: Abnormal upregulation of prostaglandin Eâ‚‚ (PGEâ‚‚) is considered to be a key oncogenic event in the development and progression of inflammation-associated human colon cancer. It has been reported that... -
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- Protective Effects of Ursolic Acid on Osteoblastic Differentiation via Activation of IER3/Nrf2
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Lee SI
- KMID: 2460998
- J Dent Hyg Sci.
- 2019 Sep;19(3):198-204.
- doi: 10.17135/jdhs.2019.19.3.198
BACKGROUND: Oxidative stress is a known to be associated with in the pathogenesis of many inflammatory diseases, including periodontitis. Ursolic acid is a pentacyclic triterpenoid with has antimicrobial, antioxidative, and... -
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- Nrf2-Heme oxygenase-1 modulates autophagy and inhibits apoptosis triggered by elevated glucose levels in renal tubule cells
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Kim JH, Kim KM, Jeong JU, Shin JH, Shin JM, Bang KT
- KMID: 2457723
- Kidney Res Clin Pract.
- 2019 Sep;38(3):318-325.
- doi: 10.23876/j.krcp.18.0152
BACKGROUND: Autophagy is a highly balanced process in which lysosomes remove aged and damaged organelles and cellular proteins. Autophagy is essential to maintain homeostasis in the kidneys. METHODS: Using human renal... -
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- Effects of heme oxygenase-1 upregulation on isoproterenol-induced myocardial infarction
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Eltobshy S, Hussein AM, Elmileegy , Askar MH, Khater Y, Metias EF, Helal GM
- KMID: 2443608
- Korean J Physiol Pharmacol.
- 2019 May;23(3):203-217.
- doi: 10.4196/kjpp.2019.23.3.203
The present study was designed to examine the effect of heme oxygenase-1 (HO-1) induction by cobalt protoporphyrin (CoPP) on the cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide... -
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- Neuroprotective mechanisms of dieckol against glutamate toxicity through reactive oxygen species scavenging and nuclear factor-like 2/heme oxygenase-1 pathway
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Cui Y, Amarsanaa , Lee JH, Rhim JK, Kwon JM, Kim SH, Park JM, Jung SC, Eun SY
- KMID: 2438086
- Korean J Physiol Pharmacol.
- 2019 Mar;23(2):121-130.
- doi: 10.4196/kjpp.2019.23.2.121
Glutamate toxicity-mediated mitochondrial dysfunction and neuronal cell death are involved in the pathogenesis of several neurodegenerative diseases as well as acute brain ischemia/stroke. In this study, we investigated the neuroprotective... -
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- Vitamin D Improves Intestinal Barrier Function in Cirrhosis Rats by Upregulating Heme Oxygenase-1 Expression
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Wang PF, Yao DH, Hu YY, Li Y
- KMID: 2442015
- Biomol Ther.
- 2019 Feb;27(2):222-230.
- doi: 10.4062/biomolther.2018.052
Intestinal barrier dysfunction always accompanies cirrhosis in patients with advanced liver disease and is an important contributor facilitating bacterial translocation (BT), which has been involved in the pathogenesis of cirrhosis... -
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- Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway
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Zhao D, Gu MY, Xu JL, Zhang LJ, Ryu SY, Yang HO
- KMID: 2432072
- Biomol Ther.
- 2019 Jan;27(1):92-100.
- doi: 10.4062/biomolther.2018.104
Ginger, one of worldwide consumed dietary spice, is not only famous as food supplements, but also believed to exert a variety of remarkable pharmacological activity as herbal remedies. In this... -
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- Evaluation of in vitro anti-oxidant and anti-inflammatory activities of Korean and Chinese Lonicera caerulea
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Lee YS, Cho IJ, Kim JW, Lee SK, Ku SK, Lee HJ
- KMID: 2448693
- Nutr Res Pract.
- 2018 Dec;12(6):486-493.
- doi: 10.4162/nrp.2018.12.6.486
BACKGROUND/OBJECTIVES: The honeysuckle berry (HB) contains ascorbic acid and phenolic components, especially anthocyanins, flavonoids, and low-molecular-weight phenolic acids. In order to examine the potential of HB as a hepatoprotective medicinal... -
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- Antibody-based Screening of Porphyromonas gingivalis Proteins Specifically Produced in Patients with Chronic Periodontitis
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Kim HJ, Lee SW
- KMID: 2437337
- Int J Oral Biol.
- 2018 Dec;43(4):201-207.
- doi: 10.11620/IJOB.2018.43.4.201
Porphyromonas gingivalis is among the major etiological pathogens of chronic periodontitis. The virulence mechanisms of P. gingivalis is yet to be identified as its activity is largely unknown in actual... -
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- rBMSCs/ITGA5B1 Promotes Human Vascular Smooth Muscle Cell Differentiation via Enhancing Nitric Oxide Production
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Zhang Y, Ding J, Xu C, Yang H, Xia P, Ma S, Chen H
- KMID: 2429549
- Int J Stem Cells.
- 2018 Nov;11(2):168-176.
- doi: 10.15283/ijsc18079
BACKGROUND AND OBJECTIVES: Previous studies have shown that integrins alpha5beta1 (ITGA5B1) gene-modified rat bone marrow mesenchymal stem cells (rBMSCs) could prevent cell anoikis and increase the nitric oxide (NO) production.... -
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- The Novel Neuroprotective Compound KMS99220 Has an Early Anti-neuroinflammatory Effect via AMPK and HO-1, Independent of Nrf2
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Lee JA, Kim HR, Kim J, Park KD, Kim DJ, Hwang O
- KMID: 2424735
- Exp Neurobiol.
- 2018 Oct;27(5):408-418.
- doi: 10.5607/en.2018.27.5.408
We have previously reported a novel synthetic compound KMS99220 that prevented degeneration of the nigral dopaminergic neurons and the associated motor deficits, suggesting a neuroprotective therapeutic utility for Parkinson's disease.... -
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- The Effect of Microbiota on Colon Carcinogenesis
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Yoon K, Kim N
- KMID: 2425314
- J Cancer Prev.
- 2018 Sep;23(3):117-125.
- doi: 10.15430/JCP.2018.23.3.117
Although genetic background is known to contribute to colon carcinogenesis, the exact etiology of the disease remains elusive. The organ’s extensive interaction with microbes necessitated research on the role of... -
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- The Effect of ABO Blood Groups, Hemoglobinopathy, and Heme Oxygenase-1 Polymorphisms on Malaria Susceptibility and Severity
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Kuesap J, Na-Bangchang K
- KMID: 2412735
- Korean J Parasitol.
- 2018 Apr;56(2):167-173.
- doi: 10.3347/kjp.2018.56.2.167
Malaria is one of the most important public health problems in tropical areas on the globe. Several factors are associated with susceptibility to malaria and disease severity, including innate immunity... -
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- Carbon Monoxide Ameliorates 6-Hydroxydopamine-Induced Cell Death in C6 Glioma Cells
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Moon H, Jang JH, Jang TC, Park GH
- KMID: 2429057
- Biomol Ther.
- 2018 Mar;26(2):175-181.
- doi: 10.4062/biomolther.2018.009
Carbon monoxide (CO) is well-known as toxic gas and intrinsic signaling molecule such as neurotransmitter and blood vessel relaxant. Recently, it has been reported that low concentration of CO exerts... -
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- Role of Carbon Monoxide in Neurovascular Repair Processing
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Choi YK
- KMID: 2429047
- Biomol Ther.
- 2018 Mar;26(2):93-100.
- doi: 10.4062/biomolther.2017.144
Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO). Endogenous CO production occurring at low concentrations is thought to have several useful biological roles. In... -
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- Lycopene Protects Against Spontaneous Ovarian Cancer Formation in Laying Hens
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Sahin K, Yenice E, Tuzcu M, Orhan C, Mizrak C, Ozercan IH, Sahin N, Yilmaz B, Bilir B, Ozpolat B, Kucuk O
- KMID: 2416949
- J Cancer Prev.
- 2018 Mar;23(1):25-36.
- doi: 10.15430/JCP.2018.23.1.25
BACKGROUND: Dietary intake of lycopene has been associated with a reduced risk of ovarian cancer, suggesting its chemopreventive potential against ovarian carcinogenesis. Lycopene's molecular mechanisms of action in ovarian cancer... -
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- Pulegone Exhibits Anti-inflammatory Activities through the Regulation of NF-κB and Nrf-2 Signaling Pathways in LPS-stimulated RAW 264.7 cells
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Roy A, Park HJ, Abdul QA, Jung HA, Choi JS
- KMID: 2409606
- Nat Prod Sci.
- 2018 Mar;24(1):28-35.
- doi: 10.20307/nps.2018.24.1.28
Pulegone is a naturally occurring organic compound obtained from essential oils from a variety of plants. The aim of this study was to investigate the anti-inflammatory effects through the inhibitory... -
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